Recently, some countries have been distressing with the increasing number of breast cancer cases. Those cases were extremely increased in every year. Practicaly, the increasing number of patients was caused by the manual examination. Recently, some researchers have been done in the development of AI method for solving this problem. However, AI itself still has limitation since it worked in the black-box approach which was difficult to be trusted. Thus, to overcome those problems, we proposed a method that was able to classify breast ultrasound images into two classes (benign and malignant) and able to explain how the prediction was made. Our proposed method consisted of four processes i.e., pre-processing step, development of CNN model, interpretable step and evaluation. In this research work, our proposed method performed into 780 breast ultrasound images divided into three classes (133 normal, 210 malignant, and 437 benign). In the training process, our proposed method obtained training accuracy of 0.9795, training loss of 0.0675. The validation process obtained validation accuracy of 0.8000 and validation loss of 0.5096. While, in the testing process, our proposed method achieved accuracy of 0.7923. In the interpretable process using LIME, the LIME result is covered by doctor visualization. It was indicated that LIME was suitable enough in visualizing the important features of breast cancer severity. Regarding to the results, our proposed method has a potensial to be implemented as an early detection method for classifying malignancy of breast cancer in order to help the doctor in the screening process
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