Indonesian Journal of Multidisciplinary Science
Vol. 2 No. 5 (2023): Indonesian Journal of Multidisciplinary Science

Plasma Galectin-3 Biomarkers in Chronic Kidney Disease

Annesa Fadella (Faculty of Medicine, Universitas Andalas, Padang, West Sumatera
M.Djamil General Hospital, Padang, West Sumatera)

Harnavi Harun (Faculty of Medicine, Universitas Andalas, Padang, West Sumatera
M.Djamil General Hospital, Padang, West Sumatera)

Drajad Priyono (Faculty of Medicine, Universitas Andalas, Padang, West Sumatera
M.Djamil General Hospital, Padang, West Sumatera)

Deka Viotra (Faculty of Medicine, Universitas Andalas, Padang, West Sumatera
M.Djamil General Hospital, Padang, West Sumatera)



Article Info

Publish Date
25 Feb 2023

Abstract

Assessment of renal function is based on determination of serum creatinine and creatinine-based equations to assess GFR. However, this marker is not perfect or accurate, especially for longitudinal monitoring of kidney function in Chronic Kidney Disease (CKD patients). Decreased kidney function can be slowed or even anticipated with early detection, so as to avoid secondary complications. So it is important to find new biomarkers that can identify individuals at risk as early as possible. Plasma galectin-3 is a ?-galactoside-binding lectin expressed in monocytes, which plays an important role in inflammation, immunity, cancer, and is involved in the pathogenesis of atherosclerosis, diabetes, renal fibrosis and asthma. Higher galectin-3 levels were associated with reduced eGFR in a cross-sectional study. Galectin-3 is essential in various biological activities including cell growth, cell proliferation, differentiation, apoptosis, pre-mRNA splicing, transformation, angiogenesis, inflammation, fibrosis, fibrogenesis and host defense. Galectin-3 is a stable biomarker and is not associated with age, body mass index or sex. Galectin-3 is also useful for detecting the early stages of some diseases. Galectin-3 shows no circadian variation and increases slightly after exercise, returning to normal levels after 1-3 hours. Higher concentrations of galectin-3 may be associated with CKD development, indicating the potential for new mechanisms related to galectin-3 expression that may contribute to CKD development. Galectin-3 has also been reported to play an important role in renal interstitial fibrosis. Thus, galectin-3 inhibition may be a promising therapeutic strategy to prevent kidney disease progression.

Copyrights © 2023






Journal Info

Abbrev

ijoms

Publisher

Subject

Humanities Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Public Health Social Sciences

Description

Indonesian Journal of Multidisciplinary Science (IJOMS) is a scientific journal in the form of research and can be accessed openly. This journal has e-ISSN 2808-6724 and p-ISSN 2808-5957. This journal is published monthly by International Journal Labs. The development of the company made the ...