Journal of Applied Veterinary Science and Technology
Vol. 4 No. 1 (2023): April 2023

The Influence of Oral Administration of Red Dragon Fruit Peels Extract (Hylocereus polyrhizus) on Increasing High Density Lipoprotein in Male White Rats (Rattus norvegicus) Hypercholesterolemia

Ahmad Thoriqul Firdaus (Student of Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya-Indonesia)
Gandul Atik Yuliani (Division of Veterinary Basic Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya-Indonesia)
Tri Wahyu Suprayogi (Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya-Indonesia)
Nusdianto Triakoso (Division of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya-Indonesia)
Eduardus Bimo Aksono Herupradoto (Division of Veterinary Basic Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya-Indonesia)
Nanik Hidayatik (Division of Veterinary Basic Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya-Indonesia)



Article Info

Publish Date
30 Apr 2023

Abstract

Background: Hypercholesterolemia is one of the most common diseases in the world, with cholesterol levels exceeding normal levels. Hypercholesterolemia can cause various systemic disorders in the body. One of the signs is by decreasing HDL (High-Density Lipoprotein) cholesterol levels. Dragon fruit peel contains many ingredients, such as vitamin B3 (niacin), vitamin C, flavonoids, anthocyanins, and other minerals that can affect the increase in HDL production and reduce total cholesterol levels. Purpose: To know the effect of red dragon fruit peel extract (Hylocereus polyrhizus)on increasing levels of High-Density Lipoprotein (HDL) in male rats (Rattus norvegicus) hypercholesterolemia. Methods: Male rats were made hypercholesterolemic using a mixture of lard (3 ml) and egg yolk (1 g) for 14 days orally. 20 hypercholesterolemic male rats were further divided into 5 treatment groups and given dragon fruit peel extract therapy with different treatments, namely T0 negative control (CMC-Na 1% + aquadest), T1 positive control (Simvastatin 0.0013 mg/200 g BW), T2, T3 and T4 (each 100, 150, 200 mg/kg BW red dragon fruit peel extract) for 14 days orally.  Blood serum was taken on day 36 and tested in the laboratory using a chemical analyzer machine; then the data were analyzed using the univariant multiple way one-way ANOVA statistical test with a significant difference (p>0.05). Results: The P4 treatment group has an effective dose (200 mg/kg BW) to increase high-density lipoprotein (HDL) levels, while the P3 treatment group (dose 150 mg/kg BW) is less effective but can still have an effect. Conclusion: This research showed that red dragon fruit peel extract could increase HDL (High-Density Lipoprotein) cholesterol levels with an effective 200 mg/kg BW dose.

Copyrights © 2023






Journal Info

Abbrev

JAVEST

Publisher

Subject

Veterinary

Description

The scope of this journal is all about Veterinary Science and Technology field such as Animal Nutrition, Applied Veterinary Reproduction, Applied Veterinary Parasitology, Applied Veterinary Microbiology, Veterinary Public Health, Applied Veterinary Clinic. Journal of Applied Veterinary Science and ...