AcTion: Aceh Nutrition Journal
Vol 8, No 2 (2023): June

Effect of hepatogomax on serum alkaline phosphatase, bilirubin, gamma-glutamyl transferase levels in Sprague Dawley rats cirrhosis

Elfrida Sianturi (Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang)
Hery Djagat Purnomo (Fakultas Kedokteran, Universitas Diponegoro, Semarang)
Adriyan Pramono (Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang)
Endang Mahati (Departemen Farmakologi dan Terapi, Fakultas Kedokteran, Universitas Diponegoro, Semarang)
Etika R. Noer (Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang)



Article Info

Publish Date
05 Jun 2023

Abstract

Cirrhosis is the final stage of all chronic liver diseases. Complications that occur are malnutrition. Administration of Hepatogomax as an enteral formula with adequate nutrients, specifically Branched-Chain Amino Acids (BCAA) and Medium-chain Triglyceride (MCT), can reduce serum ALP, bilirubin, and GG levels. This study aimed to determine the effect of hepatogomax in different doses on serum ALP, bilirubin, and GG levels. The study used the True Experimental post-test group design. Twenty-four male rats were divided into control group K normal and K(-) cirrhotic, treatment groups P1 and P2, given TAA and hepatogomax induction, respectively, at doses of 4,87 g/200gBW/day and 14,6 g/200gBW/day. Intervention for 28 days at the PAU Laboratory, Gadjah Mada University, February 2022 to April 2022. Statistical analysis used the Kruskal Wallis and Mann Whitney Post Hoc tests. The data is the result of examining serum levels after the intervention. The results showed significant differences in ALP, bilirubin, and GGT (p<0,05) in the group of rats induced by TAA intervention with hepatogomax compared to those not given hepatogomax. There was no significant difference in the decrease in serum ALP levels between the K normal (p<0,05) and P2 (p>0,05) groups. Giving hepatogomax at a dose of 14,6 g/200BB/day reduced serum ALP, bilirubin, and GG levels. In conclusion, Hepatogomax decreased ALP, bilirubin, and GGT serum levels in rats with cirrhosis. The most significant decrease in serum ALP, bilirubin, and GGT levels was observed at the P2 dose.  

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Journal Info

Abbrev

an

Publisher

Subject

Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

AcTion: Aceh Nutrition Journal merupakan jurnal gizi dan kesehatan dengan E-ISSN 2548-5741 dan ISSN 2527-3310. Jurnal ini bertujuan untuk meningkatkan kemampuan dalam penyampaian hasil penelitian sebagai media yang dapat digunakan untuk meregistrasi, mendiseminasi, dan mengarsipkan karya peneliti ...