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All Journal JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan AcTion: Aceh Nutrition Journal Jurnal Aplikasi Teknologi Pangan Journal of Tropical Pharmacy and Chemistry
Endang Mahati
Departemen Farmakologi Dan Terapi, Fakultas Kedokteran, Universitas Diponegoro, Semarang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The influence of proton pump inhibitors on the effect of clopidogrel on the risk of recurrent ischemic stroke Endang Mahati; Jarir Atthobari; . Ngatidjan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 47, No 2 (2015)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.004 KB) | DOI: 10.19106/JMedSci004702201503

Abstract

Patients surviving with a stroke have an increased risk for recurrent stroke. Clopidogrel iswidely used to prevent recurrent stroke. However, clopidogrel may cause gastrointestinalbleeding (GIB). Therefore, proton pump inhibitors (PPIs) is recommended to reduce theside effect of clopidogrel. Unfortunately, these both drugs are metabolized in the liverby the same enzyme i.e. cytochrome P4502C19 (CYP219) that may reduce the effectof clopidogrel. The aim of this study was to evaluate the influence of PPIs on the effectof clopidogrel in the prevention of recurrent stroke. It was a hospital-based case controlstudy conducted in Bethesda Private Hospital, Yogyakarta involving 392 patients withrecurrent stroke as cases and 784 patients with first-ever stroke as controls. The exposureof PPIs during clopidogrel therapy on both cases and controls groups were recordedfrom prescription records for at least six months before index date. The duration of PPIsexposure were categorized as current expoure (less than two months before the indexdate) and recent exposure (2-6 months before the index date). The result showed therewas no influence of PPIs exposure on the effect of clopidogrel on the risk of recurrentischemic stroke (OR: 1.00; 95% CI: 0.56-1.79). Moreover, the current use of PPIs andclopidogrel could decrease the risk of recurrent ischemic stroke (OR: 0.04; 95% CI:0.01-0.41). In conclusion, there is no association between PPI exposure and the risk ofrecurrent stroke in patients receiving clopidogrel.
Body Fat Percentage, Waist Circumference and Body Mass Index are Correlated with Nitric Oxide Levels in Young Adults with Central Obesity Feriyandi Nauli; Nurhasanah Nurhasanah; Endang Mahati; Udin Bahrudin
Molecular and Cellular Biomedical Sciences Vol 5, No 1 (2021)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v5i1.165

Abstract

Background: Central obesity stands for the corner-stone of cardio-metabolic health, while nitric oxide (NO) is a major regulator of cardiovascular function. To day, the correlation between serum NO metabolites nitrate/nitrite and the obesity components in young adults remains elusive. Thus, this current study was conducted to know the correlation between serum NO metabolites levels and body fat percentage, waist circumference (WC) as well as body mass index (BMI) in young adults with central obesity.Materials and Methods: A cross-sectional study was conducted in Riau, Indonesia, involving 79 young adults aged 18-25 years, composing of 39 and 40 subjects with and without central obesity, respectively. Anthropometric measurements were performed to assess WC and BMI. Body fat percentage was measured using bioelectrical impedance analysis and serum NO metabolites levels were assessed using Griess methods.Results: Levels of serum NO metabolites were significant higher in the subjects with central obesity (168.41±12.64 μmol/L) than that of normal subjects (70.57±44.99 μmol/L, p<0.001), but the levels were no significant different between male and female subjects. Serum NO metabolites levels were strongly correlated with total body fat (r=0.618, p<0.001), visceral fat (r=0.733, p<0.001), subcutaneous fat (r=0.547, p<0.001), WC (r=0.717, p<0.001) and BMI (r=0.788, p<0.001).Conclusions: For young adults in Riau, Indonesia, levels of serum NO metabolites are higher in the central obesity group than that of the normal. In this population, body fat percentage, waist circumference and body mass index are correlated with serum nitric oxide metabolites levels.Keywords: nitric oxide, body fat percentage, young adults, central obesity
Pengaruh Substitusi Tepung Mocaf (Modified Cassava Flour) dan Rumput Laut (Eucheuma cottonii) pada Beras Analog Terhadap Uji Organoleptik dan Kandungan Serat Viqi Sajidah; Qurrota A&#039;yun Febrina Triwindiyanti; Diana Nur Afifah; Endang Mahati
Jurnal Aplikasi Teknologi Pangan Vol 11, No 1 (2022): Februari 2022
Publisher : Faculty of Animal and Agricultural Sciences, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17728/jatp.12301

Abstract

Beras analog (BA) merupakan produk dari teknologi pangan berupa beras tiruan yang dapat terbuat dari umbi-umbian, salah satunya adalah mocaf. Beras analog berbahan dasar tepung mocaf ini diperlukan penambahan pangan lain untuk memperkaya nutrisi dan dalam penelitian ini ditambahkan rumput laut Eucheuma cottonii. Pemberian tambahan rumput laut E. cottonii pada beras analog diharapkan dapat meningkatkan kandungan serat beras analog. Penelitian ini bertujuan untuk menganalisis karakteristik organoleptik beras analog serta kandungan seratnya setelah ditambah rumput laut E. cottonii. Penelitian ini menggunakan metode eksperimental dengan rancangan penelitian adalah Rancangan Acak Lengkap (RAL) yang terdiri dari 3 konsentrasi tepung rumput laut E.cottonii yaitu 0, 5, dan 15%. Uji organoleptik dilakukan untuk menentukan kualitas kesukaan. Hasil analisis menunjukkan bahwa rumput laut tidak nyata berpengaruh (p>0,05) terhadap rasa, aroma, dan warna, namun berpengaruh (p<0,05) pada tekstur dan mempunyai daya terima kosumen yang baik. Kandungan serat tertinggi terdapat pada tepung rumput laut, sedangkan kandungan serat tertinggi pada beras analog, terdapat pada konsentrasi 15%. Kesimpulannya, beras analog dengan substitusi tepung mocaf dan tepung rumput laut memiliki daya terima yang baik, tekstur dan kandungan serat yang spesifik.Effect of Substitution of Mocaf (Modified Cassava Flour) Flour and Seaweed (Eucheuma cottonii) on Analogue Rice on Organoleptic Tests and Fiber Content AbstractArtificial rice has been known as the product made of various tubers such as mocaf. This research used Eucheuma cottonii seaweed as additional ingredient to increase the fiber content. The aim of this study was to analyze organoleptic characteristics and fiber content of artificial rice made of mocaf and seaweed. This research used an experimental method with completely randomized design consisting of 3 concentrations of seaweed flours, i.e. 0, 5, and 15%. The results of the organoleptic test analysis showed that taste, aroma, and color were not affected by addtitional seaweed flour (p>0.05), but acceptable for consumer. However, it showed p<0.05 significant effect to fiber content and texture. Fiber content in seaweed flour was found as highest, while in the highest fiber content was found at a concentration of 15% seaweed flour. As conclusion, artificial rice with the substitution of mocaf flour was found as good acceptance for consumer with a spesific value for texture, and fiber content.
Tingkat Penerimaan, Kadar Zat Besi dan Vitamin C Sorbet Berbahan Daun Kelor dan Jambu Biji Merah untuk Anemia Defisiensi Besi (Level of Acceptance, Iron and Vitamin C Content of Moringa Leaves and Red Guava Sorbet for Iron Deficiency Anemia) Tiffany Nisa Arviyani; Diana Nur Afifah; Etika Ratna Noer; Gemala Anjani; M. Zen Rahfiludin; Endang Mahati
Jurnal Aplikasi Teknologi Pangan Vol 11, No 1 (2022): Februari 2022
Publisher : Faculty of Animal and Agricultural Sciences, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17728/jatp.11471

Abstract

AbstrakPenelitian ini bertujuan menganalisis tingkat penerimaan, kadar zat besi dan vitamin C sorbet berbahan daun kelor dan jambu biji merah. Anemia defisiensi besi merupakan penurunan simpanan zat besi karena kehilangan zat besi tubuh (perdarahan, infeksi, gangguan penyerapan zat besi, dan kondisi peningkatan kebutuhan zat besi), yang mengakibatkan suplai zat besi tidak mencukupi untuk produksi sel darah merah (eritropoiesis). Anemia defisiensi besi dapat mengakibatkan penurunan daya tahan tubuh dan produktivitas. Pengembangan produk pangan dapat dilakukan sebagai upaya penanggulangan anemia defisiensi besi, dengan menggabungkan pangan sumber zat besi non-haem dengan pangan sumber vitamin C. Sorbet berbahan daun kelor dan jambu biji merah dapat dimanfaatkan sebagai alternatif snack berbasis pangan fungsional untuk mengatasi anemia defisiensi besi. Penelitian dilakukan 2 tahap, yaitu penelitian pendahuluan berupa uji tingkat penerimaan dengan metode hedonik pada 34 panelis. Formula yang diujikan meliputi, sorbet pengenceran 50 mL (formula 1), 100 mL (formula 2), dan 150 mL (formula 3). Tahap selanjutnya, formula terpilih dengan skor hedonik tertinggi dianalisis kadar zat besi dengan metode XRF dan vitamin C dengan metode HPLC. Formula terbaik berdasarkan uji tingkat penerimaan adalah sorbet dengan pengenceran 100 mL (formula 2). Sorbet formula 2 memiliki rerata kadar zat besi sebesar 0,3 mg/100 g dan vitamin C sebesar 80,17 mg/100 g. Sorbet formula 2 memberikan kontribusi zat besi terhadap AKG remaja putri usia 13-15 dan 16-18 tahun sebesar 2%. Sorbet formula 2 memberikan kontribusi vitamin C terhadap AKG remaja putri usia 13-15 dan 16-18 tahun masing-masing sebesar 123,3% dan 106,9%. AbstractThis study was aimed to analyze the level of acceptance, iron and vitamin C sorbet content made from moringa leaves and red guava. Iron deficiency anemia was a condition of decreased in iron stores due to loss of body iron (bleeding, infection, impaired iron absorption, and increased iron demand conditions) that resulted in insufficient iron supply for red blood cell production (erythropoiesis). Iron deficiency anemia could result in decreased endurance and productivity. One of the efforts to deal with iron deficiency anemia was the development of food products. Food product development could be done by combining non-haem iron source food with vitamin C source food. Sorbet made from moringa leaves and red guava could be used as an alternative to a functional food-based snack to treat iron deficiency anemia. The study were conducted  in 2 stages, preliminary study in the form of a hedonic test on 34 panelists to analyze level of acceptance. The formulas tested included, sorbet with a dilution of 50 mL (formula 1), 100 mL (formula 2), and 150 mL (formula 3). The next step, one formula was selected with the highest hedonic score analyzed the iron content by the XRF method and the vitamin C content by the HPLC method. The best formulation based on the level of acceptance test  must be sorbet with 100 mL dilution (formula 2). Iron content averages of formula 2 must be 0.3mg/100 g and vitamin C content averages must be 80.17mg/100 g. Formula 2 contribute to iron based on adolescents girl’s AKG (13-15 and 16-18 years old) was 2%, vitamin C based on adolescents girl’s AKG (13-15 and 16-18 years old) were 123.3% and 106.9% respectively.
Effectivity of the jackfruit leaves infusion (Artocarpus heterophyllus l.) as a larvacide to the mortality rate of Aedes aegypti larva Fina Alvia Rahma; Endang Mahati; R.A. Kisdjamiatun RMD; Ryan Halleyantoro
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 14, No 1 (2020): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2147.783 KB) | DOI: 10.33533/jpm.v14i1.1461

Abstract

Larval stage control using temephos, a chemical larvicide powder, was not completely safe. WHO recommended to use biological controls. Jackfruit leaves which contain saponins, flavonoids, and tannins can be used as alternate. This study was conducted to determine the effectivity of jackfruit leaves (Artocarpus heterophyllus L.) infusion on the mortality of Aedes aegypti larvae using post test only control group design. 600 of Aedes aegypti larvae were divided into 1 control group and 5 experiment groups that consist  jackfruit leaves infusion concentrations of 4%, 8%, 12%, 16%, 20% with four times replication. The mortality of larvae was observed every 8 hours to 48 hours. The LC50 and LT50 were obtained by probit analysis were 3.842% and 2.150 hours. In the repeated Kruskal-Wallis test and Mann-Whitney, there were significant differences (p<0.05) in the mortality of Aedes aegypti larvae that died based on differences in the concentration of jackfruit leaf infusion. In the Spearman test, there were significant correlations (p<0.05) between the concentration of jackfruit leaves infusion and the mortality of Aedes aegypti larvae and the death rate of Aedes aegypti larvae. The results of the study are expected to be alternatives to chemical larvicides commonly used by the community.
The effect of additional protein, phosphatidylcholine, phosphatidylserine, and inulin on S100β levels of acute ischemic stroke patients at Dr. Kariadi Central Hospital, Semarang Stephani Nesya Renamastika; Endang Mahati; Martha Kartasurya; Dodik Pramukarso; Dwi Pudjonarko; Retnaningsih Retnaningsih
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 9, No 2 (2021): Juni
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.9.2.172-183

Abstract

Background: The brain releases biochemical substrates, such as S100β protein, into circulation in response to ischemic conditions as a sign of damage in nerve cells and disruption of the blood-brain barrier’s integrity. Thrombolytic therapy has led to the development of many neuroprotective therapies such as protein, phosphatidylcholine, phosphatidylserine, and inulin, which can be added to food products. Protein, phospholipids, and inulin, have a neuroprotective impact on nerve cells in the brain and blood-brain barrier.Objective: To prove the effect of protein, phosphatidylcholine, phosphatidylserine, and inulin on S100β levels and clinical outcomes in patients with acute ischemic stroke.Materials and Methods: This study was done in a single-blind RCT. Eighteen ischemic stroke patients were randomly divided into nine subjects for the intervention group and nine subjects for the control group. The Control group received 250 ml conventional formula milk (11.8 g protein) 3 times/day. The intervention group received 250 mL commercial milk 3 rimes/day which contained 15 g protein with 128 mg phosphatidylcholine, 32 mg phosphatidylserine, and 3 g inulin. All of the groups were given hospital-standard therapy for ischemic stroke. S100β levels were measured at pre and post-intervention.Results: Pre and post S100β levels in intervention and the control group did not show any statistically difference (p = 0.777 and p = 0.096), but there was a trend of decreasing  levels of S100β in the intervention group (-24.6 + 252.0 pg/mL) versus control group (135.8 + 216.2 pg/mL).Conclusions: The addition of protein, phosphatidylcholine, phosphatidylserine, and inulin did not have a significant effect on S100β levels.
Factors Affecting Patient Adherence to Pharmacological Therapy in Gout Arthritis and Hyperuricemia Dzaki Edmonda Setyawan; Endang Mahati; Nani Maharani
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 3 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i3.32688

Abstract

Abstract Background: Pharmacological therapy to reduce serum uric acid levels in gouty arthritis and hyperuricemia patients is essential to prevent gout flare and other hyperuricemia-related morbidities. However, only about 50% of gout arthritis patients adhered to their treatment. Knowing the factors influencing adherence to therapy can be used as a reference for health services to improve adherence.Objective: This study aimed to analyze the factors that influenced the patient's adherence to gouty arthritis and hyperuricemia pharmacological therapy.Methods: This was an observational study with a cross-sectional approach. Subjects were the patients in Wuryantoro Community Health Center, Wonogiri Regency, diagnosed with gouty arthritis or hyperuricemia due to a disorder in purine metabolism. Sampling was done by a consecutive sampling method. Questionnaires with the related medical record were used to collect the necessary data. Research variables were knowledge, attitudes and behavior, gender, age, occupation, insurance, distance from residence to health care facilities, and adherence to therapy which was in binary.Results: Sixty-one percent from a total of 41 respondents were found to be non-adherence to pharmacological therapy. Knowledge, attitudes, and behavior towards therapy, educational level, availability of health insurance, and distance to health facilities were significantly correlated to treatment adherence (p < 0.05). Sex, age, and occupation were not correlated to adherence.Conclusion: Factors influencing adherence were knowledge, attitudes and behavior, academic background, insurance, and the distance from residence to health care facilities.
Immunosupressant Effect of the Extract of Tridax procumbens on Lymphocyte Cells Line from Patients with Systemic Lupus Erythematous: Immunoglobulin Gbiomarker Abdul Khairul Rizki Purba; Endang Mahati; Yolanda Dyah Kartika; Indwiani Astuti; Nyoman Kertia
Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 2 (2013): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (75.228 KB) | DOI: 10.25026/jtpc.v2i2.50

Abstract

Systemic Lupus Erythematous (SLE) is one of the major autoimmune diseases that can cause severe damage to the tissues and organs in the body and lead to high mortality rates. The clinical manifestations are characterized by the production of autoantibody immunoglobulin G (Ig G) that fights component of the nucleus. The present scientific information issues about peculiar property of Tridax procumbens as immunosuppressant by inhibiting enzyme of cyclooxygenase-2 (COX-2) on surface of B cells. This study approved effect of the extract of Tridax procumbens on human lymphocytes cells line with SLE disease. The aim of this study was to approve effect of extract of Tridax procumbens in suppressing Ig G concentration from patient with stable SLE and patient with active SLE in vitro. This study was an in vitro experimental design on lymphocytes cell line that was isolated from whole blood patient with stable SLE and active SLE. Lymphocyte cells from healthy volunteer were also collected as control. American Rheumatism Association Diagnostic was used for inclusion criteria.Tridax procumbens was extracted with maceration method in solution of ethyl acetate. The extract was divided in several doses as immunosuppressant i.e.1000; 250; 62.5; 31.25; 15.13; and 3.91 µg/mL. Supernatant of the cultured cells was collected and examined for measuring Ig G concentration as secretion from activated B cells by ELISA. Ethical clearance had been completed before this study started. The extract of Tridax procumbens significantly suppressed Ig G secretion in patient with stable SLE at dose over 62.5 µg/mL, but Ig G concentration in patient with active SLE was significantly increased when compared with control. Furthermore from the analysis, effect of the Tridax procumbens extract on Ig G concentration followed dose dependent response. In in-vitro study, the extract of Tridax procumbens could significantly suppress Ig G secretion in healthy volunteer and patient with stable SLE. Otherwise, the extract does not suggest for patient with active SLE and it needs caution in use and investigation in-depth. Keywords: SLE, Tridax procumbens, immunoglobulin G ABSTRAK Penyakit Systemic Lupus Erythematous (SLE) merupakan salah satu penyakit autoimun yang sering menyebabkan kerusakan jaringan dan organ sehingga angka kematiannya tinggi. Karakteristik patognomonik penyakit SLE ditandai ada produksi auto antibody immunoglobulin G (Ig G) yang melawan komponen nukleosom tubuh sendiri. Penelitian ilmiah terbaru menunjukkan bahwa ekstrak Tridax procumbens memiliki efek imunosupresan melalui hambatan enzim cyclooxygenase-2 (COX-2) pada permukaan sel B. Pada studi ini menguji efek ekstrak Tridax procumbens pada cells line limfosit dari pasien SLE. Tujuan penelitian ini adalah mengetahui efek ekstrak Tridax procumbens dalam menekan konsentrasi Ig G pasien dengan SLE stabil dan pasien dengan SLE aktif secara in vitro. Penelitian ini merupakan penelitian eksperimen pada cell line limfosit yang diisolasi dari whole blood pasien dengan SLE stabil dan SLE aktif. Kelompok kontrol limfosit diambil dari sukarelawan sehat. Kriteria inklusi pasien yang mengikuti penelitian ini berdasarkan kriteria diagnostik American Rheumatism Association. Tridax procumbens diekstraksi dengan metode maserasi larutan etil asetat. Ekstrak dibagi menjadi beberapa dosis sebagai imunosupresan yaitu 1000; 250; 62,5; 31,25; 15,13; dan 3,91 µg/mL. Supernatan dari sel kultur dikoleksi dan diukur konsentrasi Ig G yang merupakan sekresi sel B dengan menggunakan metode ELISA. Persetujuan etik dilakukan sebelum penelitian dilakukan. Ekstrak Tridax procumbens menekan sekresi Ig G pasien dengan SLE stabil pada dosis diatas 62,5 µg/mL, namun konsentrasi Ig G dari pasien dengan SLE aktif meningkat secara signifikan dibandingkan dengan kontrol. Efek ekstrak Tridax procumbens pada konsentrasi Ig G mengikuti dose dependent response. Pada penelitian ini, ekstrak Tridax procumbens dapat menekan sekresi Ig G dari pasien dengan SLE stabil dan sukarelawan sehat. Pemberian ekstrak Tridax procumbens tidak dianjurkan pada pasien dengan SLE aktif, namun hal ini masih membutuhkan penelitian lebih mendalam. Keywords: SLE, Tridax procumbens, imunoglobulin G
Effect of hepatogomax on serum alkaline phosphatase, bilirubin, gamma-glutamyl transferase levels in Sprague Dawley rats cirrhosis Elfrida Sianturi; Hery Djagat Purnomo; Adriyan Pramono; Endang Mahati; Etika R. Noer
AcTion: Aceh Nutrition Journal Vol 8, No 2 (2023): June
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v8i2.969

Abstract

Cirrhosis is the final stage of all chronic liver diseases. Complications that occur are malnutrition. Administration of Hepatogomax as an enteral formula with adequate nutrients, specifically Branched-Chain Amino Acids (BCAA) and Medium-chain Triglyceride (MCT), can reduce serum ALP, bilirubin, and GG levels. This study aimed to determine the effect of hepatogomax in different doses on serum ALP, bilirubin, and GG levels. The study used the True Experimental post-test group design. Twenty-four male rats were divided into control group K normal and K(-) cirrhotic, treatment groups P1 and P2, given TAA and hepatogomax induction, respectively, at doses of 4,87 g/200gBW/day and 14,6 g/200gBW/day. Intervention for 28 days at the PAU Laboratory, Gadjah Mada University, February 2022 to April 2022. Statistical analysis used the Kruskal Wallis and Mann Whitney Post Hoc tests. The data is the result of examining serum levels after the intervention. The results showed significant differences in ALP, bilirubin, and GGT (p<0,05) in the group of rats induced by TAA intervention with hepatogomax compared to those not given hepatogomax. There was no significant difference in the decrease in serum ALP levels between the K normal (p<0,05) and P2 (p>0,05) groups. Giving hepatogomax at a dose of 14,6 g/200BB/day reduced serum ALP, bilirubin, and GG levels. In conclusion, Hepatogomax decreased ALP, bilirubin, and GGT serum levels in rats with cirrhosis. The most significant decrease in serum ALP, bilirubin, and GGT levels was observed at the P2 dose.  
Co-Authors . Ngatidjan Abdul Khairul Rizki Purba Adriyan Pramono Anjani, Gemala Diana Nur Afifah, Diana Nur Dodik Pramukarso Dwi Pudjonarko Dzaki Edmonda Setyawan Elfrida Sianturi Etika R. Noer Etika Ratna Noer Feriyandi Nauli Fina Alvia Rahma Hery Djagat Purnomo Indwiani Astuti Jarir At Thobari Kartika, Yolanda Dyah Martha Irene Kartasurya Mohammad Zen Rahfiludin Nani Maharani Nurhasanah Nurhasanah Nyoman Kertia Qurrota A&#039;yun Febrina Triwindiyanti R.A. Kisdjamiatun RMD Retnaningsih Retnaningsih Ryan Halleyantoro Stephani Nesya Renamastika Tiffany Nisa Arviyani Udin Bahrudin Viqi Sajidah