<![CDATA[Diagnosis of tuberculosis can be established through the detection of antigens by Acid Fast Bacilli (AFB), microscopy, culture, and Polymerase Chain Reaction (PCR). The World Health Organization (WHO) 2012 issued a recommendation not to use antibody detection in the diagnosis of tuberculosis. However, there is high demand from clinicians to detect anti-tuberculosis antibody in patients who are challenging to do a bacteriological examination. The purpose of this research was to determine the diagnostic value of anti-M.tuberculosis IgG and IgM Encode TB to support lung tuberculosis diagnosis.This study was a cross-sectional by using consecutively sampling, which was performed in the Dr. Soetomo Hospital, Surabaya, Indonesia, from November 2017 until May 2018. A total of 52 patients were included and evaluated for clinical or bacteriological examination using AFB microscopy or PCR (Gene Xpert) as the gold standard and tested the anti-M.tuberculosis IgG and IgM with immunochromatography. Encode Tuberculosis (TB) IgG was positive in 12 patients from the tuberculosis group and one false-positive in the non-tuberculosis group. The diagnostic sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of Encode TB IgG dan IgM were 35%, 94%, 92%, 43% and 55.7%, respectively. The specificity was high that the positive result was considered as TB; the sensitivity was low that the negative results were not excluded from TB. Encode TB IgG/IgM rapid test was not recommended to use as a single diagnostic test and must be combined with other diagnostic tests to increase the sensitivity.]]>
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