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Contact Name
Dr. dr. Puspa Wardhani, SpPK
Contact Email
admin@indonesianjournalofclinicalpathology.org
Phone
+6285733220600
Journal Mail Official
majalah.jicp@yahoo.com
Editorial Address
Laboratorium Patologi Klinik RSUD Dr. Soetomo Jl. Mayjend. Prof. Dr. Moestopo 6-8 Surabaya
Location
Kota adm. jakarta selatan,
Dki jakarta
INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
ISSN : 08544263     EISSN : 24774685     DOI : -
Core Subject : Health, Science,
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Articles 801 Documents
EFEK HEPATOTOKSIK ANTI TUBERKULOSIS TERHADAP KADAR ASPARTATE AMINOTRANSFERASE DAN ALANINE AMINOTRANSFERASE SERUM PENDERITA TUBERKULOSIS PARU Delita Prihatni; Ida Parwati; Idaningroem Sjahid; Coriejati Rita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.831

Abstract

Tuberculosis (TB) is still a major health problem, especially in the developing countries. The combination of antituberculosis drugs are generally recommended for the treatment of tuberculosis. Van Crevel study in Jakarta found that most (70%) of patients with pulmonary TB who received combined antituberculosis drugs with standard (450 mg) dose rifampicin had very low plasma rifampicin level. Based on this results, TB Research and Clinical Trial Centre Bandung & University Medical Centre Nijmegen, The Netherlands conduct the study which compared clinical outcome between standard and high (600 mg) dose of rifampicin. Most of antituberculosis drugs currently available are very low in causing acute and chronic toxicities, however we must keep aware of side effect during the treatment. The most serious adverse effect of several drugs is liver damage (drug induced hepatitis) and potentially fatal hepatitis. To detect liver demage earlier aspartate aminotransferase( AST) and alanine aminotransferase (ALT) serum level were examined during antituberculosis treatment. The aim of this study was to determine AST and ALT serum level at intensif phase of antituberculosis treatment with standard and high dose rifampicin. The study had been done from August 2003 to September 2004 at Dr Hasan Sadikin Hospital and Balai Pengobatan Penyakit Paruparu, Bandung. The subjects were divided randomly into 2 groups. The first group consisted of patients with category I antituberculosis drugs with standard dose rifampicin and the second group patients also category I with high dose rifampicin. Aspartate aminotransferase and ALT serum level were examined at week 0 (before treatment), 2nd, 4th, and 8th. This was randomized clinical trial with paralel design study. Statistical analysis used paired t test to compare the dose effect of rifampicin to AST and ALT serum level changes, t independent test to compared mean difference of AST and ALT serum level changes which is projected by profile analysis. p value < 5%.. The prevalence of the hepatotoxicity were 17.39% of standard dose and 18.17% of high dose rifampicin. The hepatotoxicity were mild and moderate level,and it was already present at 2 weeks of therapy. There were no significant difference of AST and ALT serum level beetween those two groups. Conclusion: In this study antituberculosis drugs with high dose rifampicin were safe for TB patients.
PENENTUAN DEFISIENSI BESI ANEMIA PENYAKIT KRONIS MENGGUNAKAN PERAN INDEKS sTfR-F Adang Muhammad; Osman Sianipar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.833

Abstract

Background: The highest prevalence of nutrition problem due to nutrition deficiency is iron deficiency. Chronic disease anemia often occurs coincide with iron deficiency and both show of low iron serum appearance. Difficulty occurs when iron deficiency determined in chronic disease anemia by routine parameters. Bone marrow stainning can indicate iron store, but it is invasive. Therefore it needs another more practical parameter that has higher diagnostic value. Objective: To know the more practical parameter that can determine iron deficiency in chronic disease anemia Discussion: Ferritin serum indicates iron store in the body, whereas transferin receptor indicates functional of iron uptake in the erythrocyte. Changes of ferritin level due to inflammation process are varies. Recent evidence shows different changes of transferin receptor between iron deficiency anemia and those in chronic disease anemia. In chronic disease anemia, receptor transferin level increase but not as high as in those who suffer from pure iron deficiency anemia. Studies on groups of iron deficiency anemia, iron deficiency with acute inflammation, chronic disease anemia and healthy control population showed significance differences of receptor transferin among them. sTrF-R index is an index derived from the calculation of transferin receptor level divided by logarithmic of the ferritin level. The usage of sTfR-F index indicates more significance difference as compared to transferin receptor. Its sensitivity and specificity increase when it is applied to diagnose iron deficiency in elderly group. Conclusions: sTfR-F index is more sensitive and specific for the determination of iron deficiency in chronic disease anemia
GAMBARAN MIKROBIOLOGI ISPA (INFEKSI SALURAN PERNAPASAN ATAS) DI SEKELOMPOK JAMAAH HAJI SURABAYA TAHUN 2004 Prihatini Prihatini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.834

Abstract

Upper respiratory tract infection usually has been presence on hajj pilgrims after they spent at the holy Mecca. They are known by long duration cough until they were come home. The pilgrims have been given health education how to live in Mecca and Medina before they go to Saudi Arabia and had meningitis vaccination as well. The purpose of this study is to know what the cause of the upper respiratory tract infection. If the pathogens have been found, before departure the infected pilgrims have been given antibiotics to prevent the pilgrimage ceremony to be disturbed.. Regarding the infection problems this study will be done, to give information whether the pathogenic that cause URI is from Indonesia or Saudi Arabia. About 118 people partially from Surabaya’s pilgrims were divided into 1st and 2nd groups (53 and 65 persons). Each group have been examined their pharyngeal swab before the departure to Mecca and after arrival in Surabaya. The samples were kept in transport media, than sent to the Clinical Pathologic Laboratory at Dr Soetomo Hospital. The swab samples were isolated and identificated after the cultivation in the incubator at the laboratory. From the118 pilgrims, only 95 persons completed the laboratory examination before the departure to Mekah and after they arrived in Surabaya. It is found before departure 5 person (5%) contaminated by pathogenic microorganism, four from K. pneumoniae and one A betahemolytic Streptococcus group. After their arrival about 97% have normal flora, but two of them contaminated by Gamma Streptococcus regarding to these results it is concluded that URI may cause by the environment, difference of weather or viral infection origin Because in the town at Saudi Arabia the pilgrim lived together with other peoples which came from various countries of the world.
MOLECULAR PATHOLOGY OF CEREBROVASCULAR ATHEROSCLEROSIS Marsetio Donosepoetro
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.835

Abstract

Cerebrovascular disease are the third most common cause of death in Western countries. The most frequent manifestation of disease is a sudden episode of neurological deficit termed stroke which is the result of cerebral haemorrhage or cerebral infaction in the mayority of cases. Stroke secondary to atherosclerosis is most common in people over 50 years old.The incidence of stroke rises dramatically with ages, with the risk doubling with each decade after 35 years old. About 5 % of people over 65 years old have at least one stroke. Atherosclerosis is condition where fatty acid deposits occur in the inner lining of arteries and the forming of atherosclerotic plaque,a mass consisting of fatty deposit, and blood platelets.The plaque may obstruct or my trigger clot,a trombus,at that location causing cerebral trombosis.It is called ischemmic stroke. The basis of the response to injury hypothesis introduced by Russel Ross is that the earliest cellular events that occur during atherosclerosis is a specialized type of chronic inflammatory response to cell injury. What may begin as a protective inflammatory reponse can become excessive and deleterious to the cell of the artery wall. The adhesion of leucocytes on endothelial cells and their trans –endothelial migration into intima are mediated by adhesion molecules on the endothelial cell membrane that mainly belong to two protein families:the selectin and the addhesion molecules.
HIPOKALEMIK PERIODIK PARALISIS Anik Widjajanti; S.M. Agustini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.836

Abstract

A 7-year-old boy of Java origin, visited the doctor with progressive weakness everytime he ate food containing Monosodium Glutamat (MSG). Progressive weakness began from his legs and spreaded to the arms as well (sometimes also to the neck). He could neither walk nor do anything for 5–6 hours then began to resolve spontaneously.. We suspected the diagnosis of hypokalaemic periodic paralysis upon the history of episodes of flacid paralysis and low serum concentration of potassium (< 3,5 mmol/L) during the attacts. The clinical examination showed that this boy is in good general and nutritional conditions; electrocardiogram, laboratory blood count, urinalisis, thyroid, liver, kidney function, and ANA test were normal as well. The family history of flacid paralysis was negative. We have promptly administered potassium orally and his condition was improved progressively including less degree of flacid paralysis (the weakness). A genetic testing, electromyography (EMG), muscle biopsy and another examination has not performed.
SINDROMA CUSHING PADA KEHAMILAN Yetti Hernaningsih; Sidarti Soehita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.837

Abstract

A 32 years old woman, pregnant 24-25 weeks, was admitted to the hospital with complaints of weakness, 6 years amenorrhoe, bruises on the skin and hair loss. Physical examination showed full moon face, buffalo hump, striae lividae, and echymosis. She was diagnosed as Cushing Syndrome with possible etiology adrenal tumor based on laboratory results: glucose intolerance, hypokalemia, increament of plasma cortisol before and after dexamethason supression tests (1352 and 1297 nmol/l), also decreement of plasma ACTH (5 pg/ml). During 22 days hospitalization, the patient’s condition became worse (heart failure, sepsis and shock).
KEMAMPUAN UJI TABUNG WIDAL MENGGUNAKAN ANTIGEN IMPORT DAN ANTIGEN LOKAL Puspa Wardhani; Prihatini Prihatini; Probohoesodo M.Y
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.838

Abstract

Despite of its higher specificity than Widal-slide test, Widal-tube test is not widely used by medical laboratories because it is not practical and each laboratory has to produce their own antigens. The Laboratory must have sufficient microbiology equipments and reagents to produce antigens. REMEL® provides ‘ready for use’ antigens to perform Widal-tube test. To Compare and correlate Widal-tube test using REMEL® imported antigens and local antigens (produced by lab. Clinical pathology Dr. Soetomo hospital). The samples were tested by Widal-tube test, using REMEL® and local antigens, comparing Salmonella typhi (ST) O antigen, ST H antigen, S. paratyphi (SP) A H antigen, and SP B H antigen for each method, with twofold dilution from 1/40 until 1/1280. The number of samples was 55. The results are defined as pathologic (above cut-off value) and non pathologic (below cut-off value). REMEL® ST O antigen had a significant correlation to local antigens (r = 0.665, p < 0.01). REMEL® ST H antigen also had a significant correlation to local antigen (r = 0.671, p < 0.01), REMEL® SP B H has no significant correlation to local antigen (r = 0.389, p < 0.01). All samples (55) showed negative results (non pathologic) using SPA H local antigen. When using REMEL® SPA H antigen, 51 were non pathologic and 4 were pathologic. Widal-tube test using REMEL® antigens has significant correlation with local antigens so it might be considered to be used for diagnosing typhoid fever.
PENINGKATAN MUTU PEMERIKSAAN DI LABORATORIUM KLINIK RUMAH SAKIT Kahar, Hartono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.839

Abstract

Clinicians always needs the results of clinical laboratory with quality assurance. The performance of good quality laboratory depends on pre-analytic, analytic as well as post analytic processes. It is also influenced by reagents and methods types as well as personal laboratory work. The goal of laboratory examinations quality runs between QMS, or Five Q’s, which consist of: Quality planning, laboratory practice, control, and assurance and Quality improvement. The quality laboratory examinations depend on the accuracy and precision results.
HASIL TES LAJU ENDAP DARAH CARA MANUAL DAN AUTOMATIK N. Ibrahim; Suci Aprianti; M. Arif; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 2 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i2.840

Abstract

Erythrocyte sedimentation rate (ESR) is a non specific test that describes changes in protein plasma and is useful to determine inflammatory case. ESR is determined by using manual and automatic. In big cities, automatic method is more popular now days, but in periphery area, manual method is still the choice. To find out correlation between the results of manual and automatic tests. Cross sectional study was carried out among 200 patients at dr. Wahidin Sudirohusodo Public Hospital of Makassar from September to October 2005. The data were analyzed using R-Square (R2) and regression test using SPSS 11.5. There is significant correlation (P<0.05) among vertical manual, oblique manual and automatic methods. R2 of automatic and vertical methods are 0.95 (the first one hour) and 0.94 (the second one hour), as well as the R2 of oblique and vertical methods are 0.62 (the first one hour) and 0.87 (the second one hour) respectively. There is correlation among the results of the three methods. To convert the result of automatic to vertical, an equation of vertical score = 4.32 + 1.00 (automatic score) can be used. Meanwhile, conversion of oblique score to vertical score is vertical score = 7.58 + 0.99 (oblique score).
ANALISIS KADAR OSTEOKALSIN SERUM OSTEOPENIA DAN OSTEOPOROSIS N Sennang AN; Mutmainnah Mutmainnah; RDN Pakasi; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 2 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i2.841

Abstract

Osteoporosis is a metabolic bone disease, characterized by decreased of bone mass density. Its incidence is higher in older population.Serum osteocalcin level is related to the rate of bone turnover. To analyze serum osteocalcin level on osteopenic and osteoporosis subjects.We examined 61 subjects for detecting osteopenia and osteoporosis by Sahara densitometer and measuring serum osteocalcin level byElecsys N-MID Osteocalsin Assay test. Of 21 men and 40 women, prevalence of osteopenia and osteoporosis were higher in women(57.5% and 32.5%) than men (42.9% and 23.8%). Most of osteoporosis subjects were in ≥ 60 years group and osteopenic subjects werein 50–59 years group (p<0.05). Mean of serum osteocalcin on osteoporosis subjects (26.70 ng/mL) was higher than osteopenic (23.78ng/mL) and normal (19.16 ng/mL) subjects (p<0.005). Prevalence of osteopenia and osteoporosis were higher in women than men. Theincidence of osteoporosis was related to the increase of age. Serum osteocalcin level was related to the severity of diagnosis category.

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