<![CDATA[Nanotechnology has rapidly grown in various research fields to treat oxidative stress in diabetes,including medicine and phytomedicine. Previous research showed that Acalypha hispida has strongantioxidant activity in vitro and anti-hyperglycemic activity in vivo. However, the size reductionin the crude extract should be applied to decrease the doses and increase the efficacy. The researchobjective was to evaluate the nano-extract of A. hispida leaves on Cu,Zn-SOD antioxidant content inthe pancreas of diabetic rats. The analysis of Cu,Zn-SOD antioxidant content was carried out usingimmunohistochemistry. Cu,Zn-SOD content of pancreas in diabetic rats (DMC) was significantlylower than in normal rats (NLC). The antioxidant content of Cu,Zn-SOD in MET, CAH, NAH3, andNAH6 groups was significantly higher than in the DMC group of the pancreas of diabetic rats. Nanoextractof A. hispida showed a better effect in increasing Cu,Zn-SOD antioxidant content than crudeextract. The result concluded that nano-extract of A. hispida leaves increased Cu,Zn-SOD antioxidantcontent in the pancreas of diabetic rats.]]>
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