This study aims to describe cases of transmission of HIV, hepatitis B and syphilis from mother to child and how the role of antenatal education in supporting the triple elimination program. This research was conducted using a systematic literature review approach. Researchers collected data from research articles that have been published in Scopus indexed international electronic journals. Data was collected using several keywords with the Google search engine and portals providing articles from Scopus indexed journals, such as ScienceDirect, MDPI, and NCBI. The data collected was then analyzed by researchers using an interactive data analysis model. The results of the analysis found that the implementation of triple elimination has been successfully carried out in various countries, although there are still various obstacles that must be faced in its implementation. Furthermore, several studies have also found that antenatal education has an important role in reducing the risk of transmission of HIV, hepatitis B and syphilis from mother to child. So, it can be concluded that antenatal education is crucial to provide in order to support the triple elimination program to prevent cases of transmission of HIV, hepatitis B and syphilis from mother to child
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