Jurnal Kedokteran Hewan
Vol 10, No 1 (2016): March

AKTIVITAS BEBERAPA SENYAWA TURUNAN BENZOPIRAN (CHROMONES) DAN BENZOFURANON (COUMARANONES) TERHADAP Steinernema feltiae (The Activities of Benzopyran (Chromones) and Benzofuranones (Coumaranones) Derivatives against Steinernema feltiae)

Khairan Khairan (Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Syiah Kuala, Banda Aceh)
Muhammad Bahi (Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Syiah Kuala, Banda Aceh)
Claus Jacob (School of Pharmacy Universitaet des Saarlandes Saarbruecken Saarland, Germany)
Rinaldi Idroes (Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Syiah Kuala, Banda Aceh)

Article Info

Publish Date
15 Mar 2016

Abstract

This study was purposed to inquire the activities of benzopyran (chromones) and benzofuranones (coumaranones) derivatives against Steinernema feltiae (S. feltiae). The toxicity assay against S. feltiae showed that benzopyran derivatives 2, 3, 4, 6, and 9 have the highest activity on S. feltiae with viabilities percentage of 50%. The compound 9 demostrated the highest activity with LD 50 and LD values, 7.2 and 52.2 μM, respectively. The activities of compound 7 and 10 showed the lowest toxicity. Interestingly, the activity of benzofuranone derivatives showed significant activities against S. feltiae. Compare to benzopyran derivatives, the benzofuranone derivatives has the highest toxicity, in particular compound 13 with LD 5.45 μM. The nematicidal assay showed that benzofuranones (coumaranones) derivatives revealed higher activities than benzopyran (chromones) derivatives.Key words: chromones, benzopyran, coumaranones, benzofuranone, and Steinernema feltiae

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Journal Info
Jurnal Kedokteran Hewan
Website

Abbrev

JKH

Publisher

Universitas Syiah Kuala

Subject

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

Description

Jurnal Kedokteran Hewan (J. Kedokt. Hewan), or Indonesian Journal of Veterinary Sciences is a scientific journal field of veterinary sciences published since 2007, published FOUR times a year in March, June, September, and December by Universitas Syiah Kuala (Syiah Kuala University) and Indonesian ...