IJOEP : International Journal of Ecophysiology
Vol. 5 No. 2 (2023): International Journal of Ecophysiology

PLASMA β-SECRETASE1 (BACE1) LEVELS AS MARKER OF COGNITIVE FUNCTION DECLINE IN ELDERLY

Syahfira A Syahna (Unknown)
Muhammad Ichwan (Unknown)
Nuraiza Meutia (Unknown)
Jelita Siregar (Unknown)
Zulham Yamamoto (Unknown)

Article Info

Publish Date
19 Oct 2023

Abstract

BACE1 which forms amyloid plaques consisting of amyloid β peptides is a typical neuropathological lesion in the brain of Alzheimer's disease. Many studies have shown that β-amyloid is central to the pathophysiology of Alzheimer's disease and may play an early role in neurodegenerative disorders. The BACE1 enzyme forms amyloid β plaques. The BACE1 protein is detectable in plasma and its levels are significantly increased in patients with mild cognitive impairment and future Alzheimer's. This Aβ peptide accumulates into senile plaques causing the characteristics of Alzheimer's disease, can cause neuronal death and cognitive decline

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Journal Info
IJOEP : International Journal of Ecophysiology
Website

Abbrev

ijoep

Publisher

Universitas Sumatera Utara

Subject

Agriculture, Biological Sciences & Forestry

Description

International Journal of Ecophysiology (IJOEP) is a peer-reviewed biannual journal (February and July) published by TALENTA Publisher and organized by Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara (USU) as an open-access journal. It welcomes full research articles in the ...