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All Journal Jurnal Kedokteran Syiah Kuala International Journal of Integrated Health Sciences Pharmaciana: Jurnal Kefarmasian Media Ilmu Keolahragaan Indonesia Buletin Farmatera Jurnal Keperawatan dan Fisioterapi (JKF) JURNAL FARMASIMED (JFM) IJOEP : International Journal of Ecophysiology

Yamamoto, Zulham

Department Of Histology, Faculty Of Medicine, Universitas Sumatera Utara

Author-ID : 2028145

Agriculture, Biological Sciences & Forestry Health Professions Medicine & Pharmacology Other

Published : 10 Documents Claim Missing Document

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Articles

Effect of Exercise Intensity in Glut4 Expression on Type 2 Diabetes Mellitus Rat Rahmi, Rahmi; Machrina, Yetty; Yamamoto, Zulham
Media Ilmu Keolahragaan Indonesia Vol 11, No 2 (2021): December 2021
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/miki.v11i2.34222

Glucose transporter4 (GLUT4) is the main glucose transporter in skeletal muscle. Impaired GLUT4 expression plays a role in the disorders of glycemic homeostasis such as Type- 2 Diabetes Mellitus (T2DM). Exercise can increase the GLUT4 expression in skeletal muscles so that glucose can get into the cells faster. The intensity of exercise is an important factor in reducing blood glucose levels in patients with T2DM. This study used stored biological material of gastrocnemius muscle from 15 T2DM models of Wistar rats. Rats were divided into three treatment groups namely P0 (no exercise, control), P1 (moderate-intensity continuous exercise), and P2 (vigorous-intensity continuous exercise), and treated for 8 weeks. Glut4 expression was determined by real time-PCR. The relative expression of the Glut4 gene was calculated using the Livak formula. Moderate-intensity exercise increased Glut4 expression by 2.39 times while vigorous-intensity exercise increased Glut4 expression 2.56 times compared to control. The vigorous-intensity continuous exercise expressed higher Glut4 expression than the moderate- intensity continuous one.

POTENSI EKSTRAK IKAN GABUS TERHADAP KESEMBUHAN LUKA DIABETES Bambang Prayugo; Muhammad Ichwan; Zulham Yamamoto
Jurnal Kedokteran Syiah Kuala Vol 21, No 2 (2021): Volume 21 Nomor 2 Agustus 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i2.20376

Abstrak. Luka diabetes merupakan luka kronis yang berdampak buruk bagi morbiditas, mortalitas, dan psiko-sosio-ekonomi penderita maupun keluarganya. Kondisi hiperglikemia mengakibatkan fase penyembuhan luka tidak berjalan normal. Ekstrak ikan gabus, yang dapat diberikan peroral maupun sebagai bahan kombinasi penutup luka berpotensi terhadap penyembuhan luka diabetes melalui peningkatan jumlah netrofil dan makrofag, neovaskularisasi. Selain itu, ekstrak ikan gabus meningkatkan jumlah fibroblas, deposisi kolagen, peningkatan re-epitelisasi, kekuatan regangan, dan kontraksi pada penyembuhan luka.

Anredera cordifolia leaves extract accelerates the wound healing of normal and hyperglycemic rats Gembira Arkemo Situmorang; Zulham Yamamoto; M. Ichwan; Bambang Prayugo
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Anredera cordifolia ((Madeira vein (English) or Binahong (Indonesia language)) leaves contain ingredients that promote wound healing. This study aims to determine the effect of Madeira vein leaves ethanolic extract (MLE) on normal and hyperglycemic rat wounds. This is an experimental study using male Wistar rats aged 2-3 months, body weight between 250-300 grams induced by a single injection of streptozotocin dose 60 mg/kg BW intraperitoneally. Rats were divided into 8 groups namely normal without MLE, normal with MLE 2.5% w/v, normal with MLE 5% w/v, normal with MLE 10% w/v, hyperglycemia without MLE, hyperglycemia with MLE 2.5% w/v, hyperglycemia with MLE 5% w/v and hyperglycemia with MLE 10% w/v. Punch biopsy was used to create wounds on the skin of rats with a diameter of 8 mm after the blood glucose level measurement was higher than 200 mg/dL. MLE is applied 3 times a day for 14 days on the wounds. Wound contractions occurred in line with the length of treatment days. In normal skin, the area of the wound had decreased by 22% within three days and to 76% at 14 days after wound creation. On the 14th day of treatment, the wound area of hyperglycemic rats decreased > 60%. The largest wound contraction was found when using MLE 10% w/v. Increasing the MLE dose stimulated better wound contraction/healing than control wounds. Wound healing involves many types and products of cells. Starting with hemostasis, wound healing is followed by inflammatory and proliferative phases to form new tissue, angiogenesis, and matrix formation. The MLE content is beneficial for wound healing in normal and hyperglycemic rats. MLE plays a role in accelerating wound healing in normal and hyperglycemic rats. The MLE dose of 10% w/v provides faster wound healing than the 2.5% and 5% w/v doses.

Glioblastoma following Hemorrhagic Stroke: A Case Report Kevin Kevin; Zulham Yamamoto; Bayu Dewanto
International Journal of Integrated Health Sciences Vol 9, No 1 (2021)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v9n1.2377

Objective: To report a glioblastoma (GBM) case preceded by a hemorrhagic stroke.Methods: This case reported a 53-year-old male presenting at at Murni Teguh Memorial Hospital, Medan, Indonesia, with a chief complaint of an altered mental state. The condition had been worsened for two weeks. On anamnesis, he was identified to have experienced intracerebral hemorrhage in January 2020. A follow-up head computed tomography scan was conducted in September 2020, showing a normal condition of the brain. Other oncogenic risk factors were not found. Due to convulsion in October 2020, the patient underwent a magnetic resonance imaging examination showing a cystic right temporoparietooccipital lesion and cerebral edema. Craniotomy tumor removal surgery was performed while the tumor was further examined for histopathological findings. The tumor was diagnosed as glioblastoma with microvascular proliferation and palisading necrosis.Results: There was some associations between hemorrhagic stroke and glioblastoma development.Conclusion: GBM preceded by hemorrhagic stroke is a rare case that can be diagnosed thoroughly by complete clinical and adjunct examinations.

MALONDIALDEHYDE (MDA) (ZAT OKSIDAN YANG MEMPERCEPAT PROSES PENUAAN) Novrina Situmorang; Zulham Zulham
JURNAL KEPERAWATAN DAN FISIOTERAPI (JKF) Vol 2 No 2 (2020): Jurnal Keperawatan dan Fisioterapi (JKF)
Publisher : Fakultas Keperawatan dan Fisioterapi Institut Kesehatan Medistra Lubuk Pakam

Malondialdehyde (MDA) is the end product of fat peroxidation due to the breakdown of fatty acid chains which are compounds that toxic to cells. Fat peroxidation is caused by body fat bound to free radicals such as hydroxyl radicals, superoxide anion radicals, and hydrogen peroxide, which are compounds or atoms that have unpaired electrons in their outer orbitals so that they are very reactive to cells or surrounding cell components including lipids. As a result of the lipid peroxidation reaction which is continuous which can cause various diseases and accelerate the aging process, because malondialdehyde causes cell damage. The aging process is the weakening of cells and organs as a whole starting from adulthood slowly and progressing quickly after the age of 50 years, marked by the body begins to ache and wrinkled skin. Naturally, the aging process will occur in every human being, but the process is different, some are fast (the process of premature aging) and some are slow (ageless). Although the aging process occurs for several reasons, free radicals such as melondialdehyde also contribute to accelerating the aging process. Efforts to slow down premature aging due to free radicals, namely antioxidants. As an active ingredient, antioxidants are used to protect skin from oxidation damage and prevent premature aging.

SUPEROKSIDA DISMUTASE (SOD) DAN RADIKAL BEBAS Evirosa Juliartha Simanjuntak; Zulham Zulham
JURNAL KEPERAWATAN DAN FISIOTERAPI (JKF) Vol 2 No 2 (2020): Jurnal Keperawatan dan Fisioterapi (JKF)
Publisher : Fakultas Keperawatan dan Fisioterapi Institut Kesehatan Medistra Lubuk Pakam

Superoxide dismutase (SOD) is an endogenous antioxidant that works by regulating ROS levels. This group of enzymes functions to catalyze the efficient disposal of superoxide anions. Superoxide anions are produced enzymatically and non-enzymatically. In mammals there are 3 types of SOD, namely SOD1 (CuZnSOD), SOD2 (MnSOD), SOD3 (ECSOD). Oxidative stress caused by free radicals has been reported to be involved in several diseases. Various stressors trigger ROS production, also triggering the production of enzymatic antioxidants such as catalase (CAT), hydroperoxidase (HPx) and superoxide dismutase (SOD). Free radicals cause oxidative stress when the amount in the body is excessive, this situation will cause oxidative damage at the cellular, tissue to organ levels that will accelerate the aging process and the onset of disease. Free radicals are molecules that have one or more unpaired electrons and are therefore relatively unstable. Free radicals try to stabilize themselves by taking electrons from other molecules and will produce reactive oxygen species (ROS). If there is a disturbance in the balance of ROS products with antioxidants, oxidative stress will occur which results in damage to cell components. The higher levels of oxidative stress will increase the lipid peroxidation marker which is presented as malondialdehyde (MDA) and decrease the SOD enzyme activity. Thus the role of molecules that have antioxidant activity is very necessary to ward off oxidative stress.

EFEK KATEKIN DAUN GAMBIR (UNCARIA GAMBIR ROXB) TERHADAP KADAR MALONDIALDEHID SERUM DAN EKSPRESI GEN SIRTUIN 1 PADA HIPOKAMPUS MENCIT BETINA MODEL PENUAAN Novrina Situmorang; Zulham .; Lita Feryawati
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.597

Aging is a physiological process characterized by progressive loss of physiological integrity that leads to impaired function and increased susceptibility to death. Oxidative stress is one of the factors that cause aging due to an imbalance between the amount of oxidants and antioxidants. In oxidative stress condition, malondialdehyde levels increase. D-galactose can induce aging in various organ systems. D-galactose induces oxidative stress in various organs through increased production of reactive oxygen species (ROS) and advanced glycation endproducts. In oxidative stress condition, sirtuin1 (Sirt1) produces ribose O-acetyl-ADP which, later, is reduced into ribose ADP. Both of them have a protective effect against oxidative stress. Consumption of antioxidants may prevent aging. Gambir contains health-promoting ingredients such as catechins. This study aims to determine the effect of gambier leaves catechin extract on serum malondialdehyde levels and the expression of sirtuin 1 gene in female mice aging model induced by d-galactose. This is an in vivo experiment with post test-only control group study. The samples were 28 female mice which were divided into 4 groups namely P0, P1, P2, and P3. Each group was injected 150 mg/kgBW d-galactose intraperitoneally. P1, P2, and P3 were treated orally with 100, 200, and 400 mg/kgBW gambir leaves catechin extract, respectively. Statistical test use descriftive analisys. There were significant differences in serum MDA levels in all groups (p=0.002) and there were significant differences between the P0 and P2 groups (p=0.010) and between the P0 and P3 groups (p=0.010). Sirtuin1 gene relative expressions decresead in P1 (0,49), P2 (0,74), and P3 (0,43) as compared to P0 (1.00). Conclusion. Gambir leaves catechin extract reduces serum malondialdehyde levels in aging mouse models induced by d-galactose with an optimal dose of 200mg/kgBW. and cannot reduce the relative expression of Sirt1

DEOXYRIBONUCLEASE (DNAse) DAN INHIBITOR DNAse Ismatul Fauziah Rambe; Zulham Yamamoto
Buletin Farmatera Vol 7, No 1 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i1.8984

Deoxyribonuclease (DNAse) is an enzyme that plays an important role in cell apoptosis and has the function of hydrolyzing DNA. There are two types of DNAse, namely i) DNAse I which works well at neutral pH (6.5-8.0) and requires bivalent ions such as magnesium (Mg2+) and calcium (Ca2+) for activation, and ii) DNAse II which works by good at acidic pH and does not require bivalent ions. DNAse inhibitors are required to control the activity of DNAse. Both DNAse and its inhibitors have a role in the pathogenesis of various diseases, such as in the autoimmune disease systemic lupus erythematosus. DNase inhibitors can be obtained from natural, conventional, or chemical sources.

Salivary Microflora and Its Diagnostic Importance Dina Rahmi Solihad Nasution; Zulham Yamamoto
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.12199

Saliva as a source of DNA has several advantages over blood. These advantages include easier sample collection, the sampling process can be carried out independently by participants, and stability. The study of the normal microflora of human saliva is increasingly in demand because it is related to the oral health status of each individual. Several studies explain microflora associated with diabetes, cancer, rheumatic heart disease, and others. Other things that affect the composition of the microflora of each individual include living habits, hygiene, age, and smoking. The microflora in saliva are protozoa, bacteria, yeast, and viruses. In healthy people, the characteristics of normal oral microflora found are dominant Gram-positive cocci and rods such as Actinomycetes spp and Streptococcus spp. Protozoa commonly found in saliva are Entamoeba gingivalis and Trichomonas tenax, while from the yeast Candida albicans group, the viruses most commonly found in saliva are herpes and retrovirus. Identification of normal salivary microflora can be done through microbiological and biomolecular approaches. Identification of microflora using a biomolecular approach, currently the most commonly used markers are 16S rRNA (bacteria) and ITS rDNA (fungi).

PLASMA β-SECRETASE1 (BACE1) LEVELS AS MARKER OF COGNITIVE FUNCTION DECLINE IN ELDERLY Syahfira A Syahna; Muhammad Ichwan; Nuraiza Meutia; Jelita Siregar; Zulham Yamamoto
International Journal of Ecophysiology Vol. 5 No. 2 (2023): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v5i2.14129

BACE1 which forms amyloid plaques consisting of amyloid β peptides is a typical neuropathological lesion in the brain of Alzheimer's disease. Many studies have shown that β-amyloid is central to the pathophysiology of Alzheimer's disease and may play an early role in neurodegenerative disorders. The BACE1 enzyme forms amyloid β plaques. The BACE1 protein is detectable in plasma and its levels are significantly increased in patients with mild cognitive impairment and future Alzheimer's. This Aβ peptide accumulates into senile plaques causing the characteristics of Alzheimer's disease, can cause neuronal death and cognitive decline

Co-Authors Bambang Prayugo Bayu Dewanto Dina Rahmi Solihad Nasution Evirosa Juliartha Simanjuntak Gembira Arkemo Situmorang Ismatul Fauziah Rambe Jelita Siregar Kevin Kevin Lita Feryawati M. Ichwan Muhammad Ichwan Muhammad Ichwan Novrina Situmorang Nuraiza Meutia Rahmi Rahmi Syahfira A Syahna Yetty Machrina

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