<![CDATA[Rotavirus is a highly contagious virus that enters the body through the consumption of food or water contaminated by the feces of an infected individual. After entering the body, rotavirus infects the epithelial cells lining the small intestine, which is the main site for the absorption of nutrients and water. Rotavirus infects intestinal epithelial cells by attaching to the cell surface and entering the cell. This triggers changes in the epithelial cells, including changes in the receptors present on the surface of the cells. Viruses damage epithelial cells by remodeling the cell's cytoskeleton. This causes epithelial cells to lose their ability to absorb nutrients and water properly. Over time, damage to these epithelial cells causes increased intestinal leakage, allowing fluid to enter the intestines faster than it can be absorbed. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding studies of the pathophysiology of acute diarrhea due to Rotavirus infection. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Rotavirus causes damage to intestinal epithelial cells by remodeling the cell cytoskeleton. This results in epithelial cells losing their ability to absorb nutrients and water properly. Rotavirus infection triggers inflammation in the intestines. Infected cells release inflammatory mediators, such as cytokines, which trigger response inflammation. This inflammation causes intestinal irritation, increased bowel movements, and increased mucus production. Fluid loss through diarrhea is a major consequence of rotavirus infection. Babies and children, especially, are especially susceptible to serious dehydration. Dehydration can be life-threatening if not treated quickly and efficiently.]]>
Copyrights © 2023
