Human Immunodeficiency Virus (HIV) is an infectious disease, if we pay attention to the various characteristics of disease transmission, then the form of transmission from the agent is a very important form because the nature of this disease is more often endemic and spreads more easily in society. In Indonesia, the spread of HIV/AIDS occurs evenly in almost all provinces. The prevalence of HIV cases in the population aged 15 - 49 years has increased. This research aims to produce E-Booklet. This type of research is development research using a 4-D model. The development stage of this model starts from the define stage, design stage and develop stage. The instruments used in this development research were student, lecturer questionnaires and validation sheets E-Booklet by experts, as well as a practicality assessment sheet E-Booklet filled by students and lecturers. The research results show that E-Bookletvery valid with an average score of 86.01%. The practicality assessment of students in the field trial (group evaluation size) was with a score of 95.00% with very practical criteria, and the practicality assessment by the lecturer obtained a score of 93.00% with very practical criteria. Can be concluded that E-Booklet that has been developed is included in the very valid and very practical category.
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