al Kimiya : Jurnal Ilmu Kimia dan Terapan
Vol 11, No 1 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan

Naphthalene Derivates from Bawang Tiwai Bulb Eleutherine Bulbosa in Borneo

Supriatno Salam (Faculty of Pharmacy, Universitas Mulawarman, Samarinda Department of Chemistry, Faculty of Science and Mathematics, Sultan Idris Education Universiti, Tg Malim 35900, Perak, Malaysia.)
Baso Didik Hirmawan (Universitas Mulawarman)
Erwin Samsul (Universitas Mulawarman)
Herman Herman (Universitas Mulawarman)
Islamudin Ahmad (Universitas Mulawarman)
Laode Rijai (Universitas Mulawarman)
Mohd Azlan Nafiah (Sultan Idris Education Universiti)

Article Info

Publish Date
01 Aug 2024

Abstract

Naphthalene derivative compounds named Eleutherol (1) and Eleutherol C (2) have been isolated from Bawang Tiwai Bulb Eleutherine bulbosa. We tested its cytotoxic activity against T47D breast cancer cells in vitro after isolating compounds 1 and 2 from the EtOH extract using conventional chromatography methods. Their chemical structures were elucidated based on spectroscopic analysis, including IR, HR-TOFMS, 1D, and 2D NMR, and by comparison to those related spectra previously reported. Compounds 1 and 2 were tested for their cytotoxic effects against T47D breast cancer cells and showed moderate cytotoxicity against T47D breast cancer cells with IC50 values of 117.15 and 80.21 µM, respectively, compared with cisplatin 24.07 µM.

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Journal Info
al Kimiya : Jurnal Ilmu Kimia dan Terapan
Website

Abbrev

ak

Publisher

Universitas Islam Negeri Sunan Gunung Djati Bandung

Subject

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry

Description

The scope of al Kimiya Jurnal Ilmu Kimia dan Terapan s publication included general studies and special studies The general studies are pure chemistry in general and in specific fields as follows Study of inorganic organic and biochemical substances materials that have traditionally been ...