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All Journal al Kimiya : Jurnal Ilmu Kimia dan Terapan
Herman Herman
Universitas Mulawarman
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry

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Naphthalene Derivates from Bawang Tiwai Bulb Eleutherine Bulbosa in Borneo Supriatno Salam; Baso Didik Hirmawan; Erwin Samsul; Herman Herman; Islamudin Ahmad; Laode Rijai; Mohd Azlan Nafiah
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 1 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i1.35515

Abstract

Naphthalene derivative compounds named Eleutherol (1) and Eleutherol C (2) have been isolated from Bawang Tiwai Bulb Eleutherine bulbosa. We tested its cytotoxic activity against T47D breast cancer cells in vitro after isolating compounds 1 and 2 from the EtOH extract using conventional chromatography methods. Their chemical structures were elucidated based on spectroscopic analysis, including IR, HR-TOFMS, 1D, and 2D NMR, and by comparison to those related spectra previously reported. Compounds 1 and 2 were tested for their cytotoxic effects against T47D breast cancer cells and showed moderate cytotoxicity against T47D breast cancer cells with IC50 values of 117.15 and 80.21 µM, respectively, compared with cisplatin 24.07 µM.
Co-Authors Baso Didik Hirmawan Islamudin Ahmad Laode Rijai Mohd Azlan Nafiah Samsul, Erwin Supriatno Salam