Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Vol. 4 No. 4 (2022): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)

Effect of Nonsteroidal Anti-inflammatory Drug (NSAID) in Disease Relapse, Progression, and Development of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis: NSAID and IBD

Darmadi (Unknown)
Imelda Rey (Unknown)

Article Info

Publish Date
25 Jan 2024

Abstract

This systematic review and meta-analysis investigated the association between nonsteroidal anti-inflammatory drugs (NSAIDs) and inflammatory bowel disease (IBD). Pooled analysis showed no significant association in disease relapse (OR 0.97; 95% CI 0.70–1.35; p = 0.86) and disease worsening (OR 2.06; 95% CI 0.92–4.57; p = 0.08) of existing IBD in patients receiving NSAID. In patients without prior IBD diagnosis, NSAID medication was significantly associated with risk of new-onset IBD (OR 1.51; 95% CI 1.19–1.92; p = 0.0008). Given the varied effects of NSAIDs on IBD, careful management and consideration of dosage and frequency are essential in IBD patients. Despite these insights, the heterogeneity of study designs and small sample sizes in some cases call for further large-scale research to validate these findings.

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Journal Info
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Website

Abbrev

jetromi

Publisher

TALENTA PUBLISHER

Subject

Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Journal of Endocrinology, Tropical Medicine and Infectious Diseases (JETROMI) is an international peer-reviewed journal (February, May, August and November) published by TALENTA Publisher, Universitas Sumatera Utara and managed by Faculty of Medicine, Universitas Sumatera Utara. It is dedicated to ...