<![CDATA[Indonesia merupakan Negara yang terkenal akan sumber kekayaan hayatinya, salah satunya adalah daun beluntas. Daun beluntas berpotensi sebagai antibakteri sehingga tepat untuk diformulasi dalam bentuk sediaan obat terutama gel. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak daun beluntas terhadap aktivitas antibakteri. Gel dibuat dalam empat variasi basis gel yaitu F0 (0,5% karbopol, 1% HPMC), FI (1% karbopol, 1,5% HPMC), FII (1,5% karbopol, 2,5% HPMC), dan FIII (2% karbopol, 3% HPMC). Kemudian gel diuji aktivitas antibakteri terhadap bakteri Staphylococcus aureus dengan metode Kirby bauer. Data yang diperoleh dianalisis dengan One Way Anova dengan taraf kepercayaan 95%. Berdasarkan hasil uji yang telah dilakukan dengan beberapa parameter di atas variasi karbopol 940 dan HPMC yang paling optimal dalam gel ekstrak daun beluntas adalah FIII (2% karbopol dan 3% HPMC). Namun yang mempunyai aktivitas antibakteri paling tinggi terhadap Staphylococcus aureus adalah FI (1% karbopol dan 1,5% HPMC) yang ditunjukkan dengan terbentuknya diameter zona bening di sekitar lubang sumuran termasuk dalam katagori daya hambat kuat.Kata Kunci: Antibakteri, Formulasi, Gel, Pluchea indica (L.)), Staphylococcus aureus Indonesia is a country famous for its natural resources, one of which is beluntas leaves. Beluntas leaves have the potential as antibacterial so they are suitable to be formulated in the form of drug preparations, especially gels. This study aims to determine the effect of beluntas leaf extract on antibacterial activity. The gel was made in four variations of gel bases, namely F0 (0.5% carbopol, 1% HPMC), FI (1% carbopol, 1.5% HPMC), FII (1.5% carbopol, 2.5% HPMC), and FIII (2% carbopol, 3% HPMC). Then the gel was tested for antibacterial activity against Staphylococcus aureus bacteria using the Kirby Bauer method. The data obtained were analyzed by One Way Anova with a confidence level of 95%. Based on the results of the tests that have been carried out with several parameters above, the most optimal variation of carbopol 940 and HPMC in beluntas leaf extract gel is FIII (2% carbopol and 3% HPMC). However, the one with the highest antibacterial activity against Staphylococcus aureus is FI (1% carbopol and 1.5% HPMC) which is indicated by the formation of a clear zone diameter around the well hole, which is included in the strong inhibitory power category.Keywords: antibacterial, formulation, gel, (Pluchea indica (L.)), Staphylococcus aureus]]>
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