Purpose: This study aims to determine the level of mothers' knowledge about primary immunization for infants in the working area of Puskesmas Kassi-Kassi Makassar City. Research Design and Methodology: This study used a quantitative method with a descriptive approach. Data were collected through distributing questionnaires to 37 mothers who had babies aged 0-12 months and visited the Kassi-Kassi Health Centre in February 2023. The sampling technique was accidental sampling. Findings and Discussion: The results showed that most mothers had good knowledge about primary immunization, including its definition, purpose, and benefits. The level of education and access to adequate information influence this knowledge. Most respondents knew immunization protects infants and children against tuberculosis, pertussis, hepatitis, measles, and poliomyelitis. However, some mothers still have poor knowledge, which is caused by low education levels and lack of access to information. Implications: This study makes an essential contribution to the field of public health by demonstrating the relationship between education level, access to information, and mothers' knowledge about immunization. These results can inform the development of more effective health education policies and programs. This study also highlights the importance of continued support from health workers in providing counseling on primary immunization. Further efforts are needed to improve mothers' immunization knowledge through intensive and comprehensive extension programs.
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