<![CDATA[Smoking is the biggest factor for oral cavity malignancy. An oral cavity mucous swab was performed to 30 smokers (mild, moderate and severe) and 10 non-smokers which were followed by immunocytochemistry smear using the antibody for EGF-R, c-erbB, and HSV-1 antigens to reveal the effect of smoking on the occurrence of oral cavity malignancy. The results from this experiment are analyzed statistically using one-way Anava. It is discovered that based on the assessment of the expression level towards EGF-R, and C-erbB oncogene there is a very significant difference between the smoker group and non-smoker group (p < 0.01). Meanwhile, the results from the assessment towards HSV-1 oncogene do not show significant differences between the smoker group (mild, moderate and severe) and the non-smoker group (p > 0.05). The results of this study show that the more a person smokes, the higher possibility of oral cavity malignancy and that the antibody for EGF-R and c-erbB can be used as a marker for early detection of oral cavity malignancy caused by smoking.]]>
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