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All Journal e-GIGI Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Padjadjaran Journal of Dental Researchers and Students JITEKGI Jurnal Ilmiah dan Teknologi Kedokteran Gigi

Silvi Kintawati

Department Of Oral Biology, Faculty Of Dentistry, Universitas Padjadjaran

Author-ID : 3238496

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Immunodetection of EGF-receptor, C-erbB oncogenes and HSV-1 antigene in oral mucosal swab preparation from Kretek (Clove cigarette) smokers Kintawati, Silvi
Padjadjaran Journal of Dentistry Vol 20, No 2 (2008): July
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Smoking is the biggest factor for oral cavity malignancy. An oral cavity mucous swab was performed to 30 smokers (mild, moderate and severe) and 10 non-smokers which were followed by immunocytochemistry smear using the antibody for EGF-R, c-erbB, and HSV-1 antigens to reveal the effect of smoking on the occurrence of oral cavity malignancy. The results from this experiment are analyzed statistically using one-way Anava. It is discovered that based on the assessment of the expression level towards EGF-R, and C-erbB oncogene there is a very significant difference between the smoker group and non-smoker group (p < 0.01). Meanwhile, the results from the assessment towards HSV-1 oncogene do not show significant differences between the smoker group (mild, moderate and severe) and the non-smoker group (p > 0.05). The results of this study show that the more a person smokes, the higher possibility of oral cavity malignancy and that the antibody for EGF-R and c-erbB can be used as a marker for early detection of oral cavity malignancy caused by smoking.

The difference of salivary pH before and after toothbrushing with toothpaste containing Betel leaf (Piper Betle) Fu, Soo Ling; Kintawati, Silvi; Tjahajawati, Sri
Padjadjaran Journal of Dentistry Vol 26, No 3 (2014): November
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

There has been a long history of the use of plants to improve dental health and oral hygiene. The purpose of this research was to find out the difference of salivary pH before and after toothbrushing with toothpaste containing betel leaf (Piper betel). The type of research used was quasi-experimental. Data collected were analyzed by using a paired t-test. The result shows that there is an increase of salivary pH by an average of 0.48 after toothbrushing with toothpaste containing betel leaf (Piper betel). In conclusion, there is the difference between the salivary pH before and after toothbrushing with toothpaste containing betel leaf (Piper betel).

The effect of apple (Malus Domestica) juice on the damage of mice liver cells due to paracetamol treatment Hartanto, Anthony; Dardjan, Murnisari; Kintawati, Silvi
Padjadjaran Journal of Dentistry Vol 21, No 2 (2009): July
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

The liver is an important organ for body metabolism process. Liver disease is one of serious health problems in developing countries including Indonesia. Liver damage is caused by viral infection, toxic agent exposure (medications, alcohol), hormonal disturbance, neoplasm and autoimmune diseases. The use of high dose paracetamol to reduce pain also leads to liver damage. Apple (Malus domestica) juice is a natural anti oxidant agent. This laboratory experimental study was performed to discover the effect of giving apple juice on damaged cell regeneration due to the use of paracetamol. The study was performed in 21 male mice from Swiss-Webster strain that were divided into group I, II, and III. Group, I served as control while group II received 1 mg/ml paracetamol dose for 5 days and Group III received 1 mg/ml paracetamol for 5 days and 1 ml of apple juice on the 5th to 10th day. The observation of the mice liver cells was conducted using a light microscope with 400x magnification to get the number of necrotic liver cells per view field. The results of this study showed a difference in the number of necrotic liver cells between Group II and III. ANOVA statistical test ( = 0.05) concluded that apple juice significantly helps regeneration process in damaged liver cells caused by paracetamol.

Kualitas hidup pasien dengan inflamasi mukosa mulut (Stomatitis Aftosa Rekuren) di RSGM FKG UnpadQuality of life of patients with oral mucosal inflammation (Recurrent Aphthous Stomatitis) at Dental Hospital of Universitas Padjadjaran Noviana, Lena; Kintawati, Silvi; Susilawati, Sri
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 30, No 1 (2018): April
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Pendahuluan: Stomatitis Aftosa Rekuren (SAR) dapat berdampak pada fungsi pengunyahan, penelanan dan bicara, sehingga akan mempengaruhi status gizi serta kualitas hidup. Tujuan penelitian ini adalah untuk mendapatkan gambaran kualitas hidup pasien dengan inflamasi mukosa mulut (SAR) di RSGM FKG Unpad. Metode: Jenis penelitian yang digunakan deskriptif dengan jumlah responden 32 pasien inflamasi mukosa mulut (SAR) di RSGM FKG Unpad. Kuesioner yang diisi oleh responden diadaptasi dari WHO STEP wise Approach to Surveillance â Oral Health Module tahun 2001. Hasil: Hasil penelitian menunjukkan bahwa kualitas hidup pasien dengan inflamasi mukosa mulut (SAR) di RSGM FKG Unpad adalah 43,8%, dengan rincian 33,6% untuk dimensi fungsi, 19,8% untuk dimensi psikologis, 21,9% untuk dimensi sosial, dan 100% untuk dimensi nyeri. Simpulan: Kualitas hidup pasien dengan inflamasi mukosa mulut (SAR) di RSGM FKG Unpad cukup berdampak pada dimensi psikologis, kurang berdampak pada dimensi sosial dan sangat berdampak. pada dimensi nyeri.Â ABSTRACTIntroduction: Recurrent Aphthous Stomatitis (RAS) will impact on function of mastication, swallowing and speech, so it will affect the nutritional status and quality of life. The purpose of this research was to find out the quality of life patients with oral mucosal inflammation (RAS) in Dental Hospital at Faculty of Dentistry Padjadjaran University. Methods: This research used descriptive methods with respondent of 32 patients oral mucosal inflammation (RAS) in Dental Hospital at Faculty of Dentistry Padjadjaran University. Questionnaire adapted from WHO STEPwise Approach to Surveillance â Oral Health Module 2001 was filled out by respondent. Results: The result of this study indicate that the quality of life in patients oral mucosal inflammation (RAS) in Dental Hospital at Faculty of Dentistry Padjadjaran University is 43,8%, consisted of 33,6% for dimension of function, 19,8% for dimension of psychological, 21,9% for dimension of social, and 100% for dimension of pain. Conclusion: The conclusion of this study showed quality of life patients oral mucosal inflammation (RAS) in Dental Hospital at Faculty of Dentistry Padjadjaran University was in rather impact categorise.Keywords: Oral mucosal inflammation, quality of life, recurrent aphthous stomatitis.

Hubungan indeks massa tubuh (IMT) dan laju aliran saliva pada mahasiswa preklinik angkatan 2014-2016 Fakultas Kedokteran Gigi Universitas PadjadjaranRelationship between body mass index (BMI) and salivary flow rate amongst pre-clinical students of Faculty of Dentistry Universitas Padjadjaran batch 2014-2016 Muttaqien, Inviolita Annissa; Kintawati, Silvi; Rizali, Ervin
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 29, No 2 (2017): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Pendahuluan: Saliva merupakan cairan yang sangat penting terkait dengan proses biologis di dalam rongga mulut. Laju aliran saliva merupakan salah satu indikator saliva yang berpengaruh terhadap pembentukan lesi karies maupun penyakit mulut. Laju aliran saliva dipengaruhi oleh berbagai macam faktor, salah satunya yaitu gizi. Salah satu parameter status gizi yaitu Indeks Massa Tubuh (IMT). Tujuan penelitian ini adalah untuk mengetahui apakah terdapat hubungan antara Indeks Massa Tubuh (IMT) dengan laju aliran saliva pada mahasiswa preklinik angkatan 2014-2016 Fakultas Kedokteran Gigi Universitas Padjadjaran. Metode: Jenis penelitian yang digunakan adalah deskriptif analitik. Pengambilan sampel penelitian menggunakan purposive random sampling. Sampel penelitian yang didapatkan berjumlah 90 individu yang terdiri dari 71 perempuan dan 19 laki-laki. Penelitian dilakukan dengan mengukur berat badan serta tinggi badan untuk mendapatkan nilai IMT, kemudian dilanjutkan pengukuran laju aliran saliva. Data dianalisis menggunakan uji korelasi Pearson. Hasil: Hasil uji statistik menunjukkan tidak adanya relasi signifikan antara Indeks Massa Tubuh (IMT) dengan laju aliran saliva baik pada mahasiswa perempuan maupun laki-laki, dikarenakan adanya faktor-faktor penentu lainnya. Simpulan: Indeks Massa Tubuh (IMT) tidak memiliki pengaruh yang bermakna terhadap laju aliran saliva pada mahasiswa preklinik angkatan 2014-2016 Fakultas Kedokteran Gigi Universitas Padjadjaran.Â ABSTRACTIntroduction: Saliva is a very important liquid related to biological processes in the oral cavity. Salivary flow rate is one indicator of saliva which affects the formation of caries lesions and oral diseases. Salivary flow rate is influenced by various factors, one of which is nutrition. One of the nutritional status parameters is the Body Mass Index (BMI). The purpose of this study was to determine whether there was a relationship between Body Mass Index (BMI) and salivary flow rate in 2014-2016 pre-clinical students at the Faculty of Dentistry, Padjadjaran University. Methods: The type of research used is descriptive analytic. The research sample was taken using purposive random sampling. The research sample obtained was 90 individuals consisting of 71 women and 19 men. The study was conducted by measuring body weight and height to obtain BMI values, then continued measurement of salivary flow rate. Data were analyzed using Pearson correlation test. Result: The results of statistical tests showed no significant relationship between Body Mass Index (BMI) and salivary flow rate in both male and female students, due to other determinants. Conclusion: Body Mass Index (BMI) does not have a significant effect on salivary flow rate in 2014-2016 pre-clinical students at the Faculty of Dentistry, Padjadjaran University.Keywords: Body Mass Index (BMI), salivary flow rate.

Effect of Resorbable Collagen Plug (RCP) on Extraction Wound Healing Santosa, Agustine H.; Kintawati, Silvi; Sugiaman, Vinna K.
e-GiGi Vol 10, No 1 (2022): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.v10i1.35790

Abstract: Ideal tooth extraction is removal of complete tooth structure from the alveolar bone with minimal trauma and without causing any pain. It leaves a wound in the form of an open tooth socket. Efforts to reduce the problem of wound healing can be done inter alia by forming new tissue engineering that replaces the damaged tissue with collagen which is easily absorbed biologically and has good biocompatibility. One of the wound covering materials containing collagen is resorbable collagen plug (RCP). It serves to accelerate wound healing, control bleeding due to its intrinsic hemostatic property, and accelerate the wound healing process. This was a literature review study using databases namely PubMed, Embase, Wiley Online Library, and National Center for Biotechnology. The keywords were tooth extraction, wound healing, collagen, and resorbable collagen plug. The results showed that the RCP could accelerate wound healing because it contained collagen which had the ability to stabilize blood clotting and to protect wounds. In conclusion, the use of resorbable collagen plug can accelerate wound healing after tooth extraction due to its collagen content.Keywords: Â dental extraction; wound healing process; resorbable collagen plug (RCP)Â Abstrak: Pencabutan gigi ideal adalah pengangkatan struktur gigi secara utuh dari tulang alveolar tanpa menimbulkan rasa sakit dengan trauma minimal. Tindakan pencabutan meninggalkan luka berupa soket gigi terbuka. Tujuan penyembuhan luka yaitu memperbaiki kerusakan jaringan dan fungsi organ. Upaya untuk mengurangi masalah penyembuhan luka dapat dilakukan, salah satunya dengan membentuk rekayasa jaringan baru yang menggantikan jaringan rusak yaitu dengan kolagen. Kolagen merupakan protein yang memiliki sifat mudah diserap secara biologis serta memiliki biokompatibilitas yang baik. Salah satu bahan penutup luka yang mengandung kolagen ialah resorbable collagen plug (RCP) yang berfungsi membantu mempercepat penyembuhan luka, mengontrol pendarahan oleh karena sifat hemostatik instrinsik, dan mempercepat proses penyembuhan luka. Penelitian ini merupakan suatu literatur review menggunakan database dari PubMed, Embase, Wiley Online Library, dan National Center for Biotechnology dengan kata kunci yang meliputi pencabutan gigi, penyembuhan luka, kolagen, Resorbable Collagen Plug. Hasil penelitian menunjukkan bahwa RCP dapat membantu mempercepat penyembuhan luka karena mengandung kolagen yang memiliki kemampuan untuk menstabilkan pembekuan darah dan dapat melindungi luka. Simpulan penelitian ini ialah penggunaan resorbable collagen plug dapat membantu mempercepat penyembuhan luka setelah pencabutan gigi oleh karena adanya kandungan kolagen.Kata kunci: pencabutan gigi; penyembuhan luka; resorbable collagen plug (RCP)

Perbedaan laju sekresi saliva wanita hamil dan tidak hamilDifferences in salivary flow rate of pregnant and non-pregnant women Indah Dwitasari; Rosiliwati Wihardja; Silvi Kintawati
Padjadjaran Journal of Dental Researchers and Students Vol 3, No 2 (2019): Oktober 2019
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v3i2.24068

Pendahuluan: Perubahan hormonal yang terjadi selama kehamilan dapat memengaruhi fisiologi seluruh tubuh termasuk rongga mulut. Peningkatan hormon menyebabkan perubahan mekanisme sekresi saliva oleh kelenjar saliva yang berpengaruh terhadap laju sekresi di dalam rongga mulut. Wanita hamil biasanya mengeluhkan mulut terasa penuh dan sulit berbicara, hal ini terjadi karena produksi saliva mengalami peningkatan yang secara langsung menyebabkan peningkatan laju sekresi saliva. Metode: Deskriptif komparatif dengan menggunakan teknik survei. Sampel penelitian terdiri dari 30 wanita hamil dan 30 wanita tidak hamil dengan rentang usia 20-35 tahun sesuai dengan kriteria inklusi. Unstimulated whole saliva dikumpulkan untuk menentukan besar laju sekresi saliva. Data dianalisis dengan menggunakan independent two sample t-test dengan α = 0,05. Hasil: Hasil penelitian menunjukkan rerata laju sekresi saliva wanita hamil lebih tinggi dibandingkan dengan laju sekresi saliva wanita tidak hamil (p<0,05) dengan rerata laju sekresi saliva pada wanita hamil adalah 0,7027 ± 0,152 mL/menit dibandingkan wanita tidak hamil adalah 0,5053 ± 0,160 mL/menit. Simpulan: Terdapat perbedaan laju sekresi saliva yang signifikan, dimana laju sekresi saliva wanita hamil lebih tinggi dibandingkan wanita tidak hamil, dikarenakan peningkatan jumlah hormon kehamilan, mual, dan muntah, yang terjadi selama kehamilan.Kata kunci: Kehamilan, laju sekresi saliva, saliva tanpa terstimulasi. ABSTRACTIntroduction: Hormonal changes that occur during pregnancy can affect the physiology of the whole body, including the oral cavity. Increased hormones cause changes in the salivary flow mechanism by the salivary glands which affect the flow in the oral cavity. Pregnant women usually complain that their mouth feels full and hard to speak; this condition occurs because salivary production has increased which directly causes the salivary flow to increase. Methods: Comparative descriptive using survey techniques. The study sample consisted of 30 pregnant women and 30 non-pregnant women with an age range of 20-35 years according to inclusion criteria. Unstimulated whole saliva was collected to determine the rate of salivary secretion. Data were analysed using independent two-sample t-tests with α = 0.05. Results: The results showed the average salivary flow of pregnant women was higher than non-pregnant women (p < 0.05) with the average salivary flow of pregnant women was 0.7027 ± 0.152 mL/min compared to non-pregnant women (0.5053 ± 0.160 mL/min). Conclusion: There is a significant difference in the salivary flow, where the salivary flow of pregnant women is higher than non-pregnant women, due to hormonal increase, nausea, and vomiting, which occurs during pregnancy.Keywords: Pregnancy, salivary secretion rate, unstimulated whole saliva.

Immunodetection of rasP21 and c-myc oncogenes in oral mucosal swab preparation from clove cigarette smokers Silvi Kintawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 41 No. 4 (2008): December 2008
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Smoking is the biggest factor for oral cavity malignancy. Some carcinogens found in cigar will stimulate epithel cell in oral cavity and cause mechanism disturbance on tissue resistance and produce abnormal genes (oncogenes). Oncogenes ras and myc are found on malignant tumor in oral cavity which are associated with smoking. Purpose: This research is to find the expression of oncogenes rasP21 and c-myc in oral mucosa epithelial of smoker with immunocytochemistry reaction. Methods: An oral mucosal swab was performed to 30 smokers categorized as light, moderate, and chain, and 10 non smokers which was followed by immunocytochemistry reaction using antibody towards oncogene rasP21 and c-myc is reacted to identify the influence of smoking towards malignant tumor in oral cavity. The result is statistically analyzed using Kruskal-Wallis test. Result: Based on the observation result of oncogene rasP21reaction, it shows that there is significant difference between non smoker group and light smoker, compared to moderate and chain smoker group (p < 0.01). On the other side, the observation result of oncogene c-myc indicates that there is no significant difference between the group of non smokers and the group of light, moderate, and chain smokers (p > 0.05). Conclusion: The higher the possibility of oral cavity malignancy and that the antibody for rasP21 oncogene can be used as a marker for early detection of oral cavity malignancy caused by smoking.

Corellation of p53 expressions and histopathological grading in oral cavity squamous cell carcinoma Silvi Kintawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 49 No. 3 (2016): September 2016
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Squamous cell carcinoma is a malignancy of oral cavity mostly occurred and can also metastasize. p53 gene is a tumor suppressor gene that plays an important role in carcinogenesis. The role of wild-type p53 is very important in suppressing the formation of a malignancy. p53 also has many other important functions. p53 is a suppressor of tumor/ cancer progression through the response of cell cycle to DNA damage and by giving time to repair DNA prior to replication of genes. p53 mutation, mostly occurs in a malignancy, so earlier histopathological transformation can be detected by observing p53 mutation. The prognosis of squamous cell carcinoma in oral cavity, therefore, depends on histopathological grading and clinical staging of the tumor. To enforce the histopathological grading, in addition based on histopathology differentiation, the earlier histopathological transformation can also be assessed. Purpose: This study aimed to determine the correlation of p53 expressions and histopathological grading in oral cavity squamous cell carcinoma. Method: This study was a retrospective study on 20 cases of oral cavity squamous cell carcinoma examined at Department of Pathology Anatomy in Hasan Sadikin Hospital in Bandung. Immunohistochemical examination was then performed using p53 antibodies to determine the correlation of p53 expression and histopathological grading in oral cavity squamous cell carcinoma to predict prognosis. Result: The overall results showed that there was no correlation between p53 expression and histopathological grading in oral cavity squamous cell carcinoma of the oral cavity although there was a very strong correlation between p53 expression and histopathological grading I (p<0.01). Conclusion: It can be concluded that there was no correlation between p53 expression and histopathological grading in oral cavity squamous cell carcinoma. Thus, p53 expression cannot be used to predict a prognosis.

Analysis of Ki-67 expression as clinicopathological parameters in predicting the prognosis of adenoid cystic carcinoma Silvi Kintawati; Murnisari Darjan; Winny Yohana
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 4 (2017): December 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Adenoid cystic carcinoma is a malignant salivary gland tumor located in the head and neck region. Although complete surgical resection and complementary radiotherapy have been shown to improve long-term survival rates, the prognosis of adenoid cystic carcinoma remains poor. Ki-67 expression is considered a marker for the cellular proliferation rate, the detection of its expression usually being related to the aggressiveness and unfavorable prognosis of adenoid cystic carcinoma in the salivary gland. Purpose: This study was conducted to quantify the expression of Ki-67 in adenoid cystic carcinoma and to correlate the result with clinical parameters and histopathological grading in determining the prognosis. Methods: Twenty three cases of salivary gland adenoid cystic carcinoma were identified at the Department of Anatomical Pathology, Dr. Hasan Sadikin Hospital between 2013 and 2015. Clinical data such as age, gender, location of tumor and histopathological grading was also collected. The expression of Ki-67 was assessed by immunohistochemical means to determine the correlation of Ki-67 with clinical parameters and histopathological grading. Results: There were no significant differences between the expression of Ki-67 and clinical parameters, although a very strong correlation existed between the expression of Ki-67 and histopathological grading (p < 0.01). Conclusion: There were no correlation between the expression of Ki-67 and clinical parameters, although a correlation existed between the expression of Ki-67 and histopatological grading in salivary gland adenoid cystic carcinoma. Thus, clinical parameters were unusable in determining the prognosis of adenoid cystic carcinoma, although Ki-67 expression could be used for this purpose.

Co-Authors Anthony Hartanto Anthony Hartanto, Anthony Billy Kolintama Dian Lesmana Dian Lesmana Ervin Rizali Hening Tjaturina Pramesti Inas Sania Afanina Habib Indah Dwitasari Inviolita Annissa Muttaqien Lena Noviana Murnisari Dardjan Murnisari Dardjan, Murnisari Murnisari Darjan Muttaqien, Inviolita Annissa Noviana, Lena Rizal Rizky Akbar Rizali, Ervin Rosiliwati Wihardja Rosiliwati Wihardja Santosa, Agustine H. Shelly Lelyana Soo Ling Fu Soo Ling Fu, Soo Ling Sri Susilawati Sri Tjahajawati Sri Tjahajawati, Sri Sunardhi Widyaputra Vinna K. Sugiaman Winny Yohana, Winny Yunita P. D. Nurazizah

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