INDONESIAN JOURNAL OF PHARMACY
Vol 27 No 4, 2016

FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL

Budhathoki, Uttam ( Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre, Nepal. GPO box 6250 (Kathmandu))
Gartoulla, Kshitij ( Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre, Nepal. GPO box 6250 (Kathmandu))
Shakya, Shailendra ( Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre, Nepal. GPO box 6250 (Kathmandu))

Article Info

Publish Date
23 Dec 2016

Abstract

This study was carried out to develop matrix based transdermal patches containing Atenolol. A 2 factors (HPMC (hydroxyl propyl methyl cellulose) K4M & PVP (Polyvinyl Pyrolidone) 3 level (23) factorial design was done using Design Expert® which gave 13 experiments. The patches were prepared by Solvent casting method. Propylene glycol (3%) and Tween 80 (6%) were used as plasticizer and permeation enhancer respectively. Physicochemical characteristics and In-Vitro permeation study of formulated transdermal patches were carried out. Contour plot suggested 770 mg of PVP and 265 mg of HPMC K4M in Optimized formulation. 

Copyrights © 2016




Citation Download
RIS
EndNote, Reference Manager, ProCite
BibTex
Latex, Jabref
Full PDF
853.757 KB
Original Source
Download Original
Google Scholar
Check in Google Scholar
Journal Info
INDONESIAN JOURNAL OF PHARMACY
Website

Abbrev

3

Publisher

Universitas Gadjah Mada

Subject

Medicine & Pharmacology

Description

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas ...