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All Journal INDONESIAN JOURNAL OF PHARMACY
Gartoulla, Kshitij
Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre, Nepal. GPO box 6250 (Kathmandu)
Medicine & Pharmacology

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FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL Budhathoki, Uttam; Gartoulla, Kshitij; Shakya, Shailendra
INDONESIAN JOURNAL OF PHARMACY Vol 27 No 4, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (853.757 KB) | DOI: 10.14499/indonesianjpharm27iss4pp196

Abstract

This study was carried out to develop matrix based transdermal patches containing Atenolol. A 2 factors (HPMC (hydroxyl propyl methyl cellulose) K4M & PVP (Polyvinyl Pyrolidone) 3 level (23) factorial design was done using Design Expert® which gave 13 experiments. The patches were prepared by Solvent casting method. Propylene glycol (3%) and Tween 80 (6%) were used as plasticizer and permeation enhancer respectively. Physicochemical characteristics and In-Vitro permeation study of formulated transdermal patches were carried out. Contour plot suggested 770 mg of PVP and 265 mg of HPMC K4M in Optimized formulation. 
Co-Authors Budhathoki, Uttam Shakya, Shailendra