Indonesian Journal of Chemistry
Vol 13, No 3 (2013)

A NEW CYTOTOXIC DOLABELLANE FROM THE INDONESIAN SOFT CORAL Anthelia sp.

Anggia Murni (Biopharmaca Research Center, Bogor Agricultural University, Kampus IPB Taman Kencana, Jl. Taman Kencana No. 3, Bogor 16128)
Novriyandi Hanif (Department of Chemistry, Faculty of Mathematic and Natural Sciences, Bogor Agricultural University, Jl. Agatis Wing 2 Level 4, Bogor 16144)
Junichi Tanaka (Department of Chemistry, Biology and Marine Science, University of the Ryukyus Nishihara, Okinawa 903-0213)

Article Info

Publish Date
18 Dec 2013

Abstract

One new dolabellane (1) and two known diterpenoids stolonidiol (2) and clavinflol B (3) have been isolated from the ethyl acetate extract of the Indonesian soft coral Anthelia sp. A new compound 1 exhibited a moderate cytotoxicity against NBT-T2 cells at 10 µg/mL, while known compounds 2 and 3 showed cytotoxicity at 1 and 0.5 µg/mL, respectively. Structure of the new compound 1 was elucidated by interpretation of NMR spectroscopic data (1D and 2D NMR data) and mass spectrometry (ESIMS data) as well as comparison with those of related ones. This finding should be useful for anti cancer drug development of the promising dolabellane-types compound.

Copyrights © 2013




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Journal Info
Indonesian Journal of Chemistry
Website

Abbrev

ijc

Publisher

Universitas Gadjah Mada

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry

Description

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology ...