Indonesian Journal of Chemistry
Vol 11, No 3 (2011)

EFFECT OF CROSSLINKING TO THE MECHANICAL PROPERTY OF APATITE GELATIN HYBRID FOR BONE SUBSTITUTION PURPOSES

Sunarso Sunarso (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281)
Sutarno Sutarno (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, Jl. Sekip Utara, Yogyakarta)
Kanji Tsuru (Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582)
Ika Dewi Ana (Department of Dental Biomedical Sciences, Faculty of Dentistry, Universitas Gadjah Mada, Jalan Denta 1 Sekip Utara, Yogyakarta 55281)
Kunio Ishikawa (Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582)

Article Info

Publish Date
20 Dec 2011

Abstract

The clinical success of current generation of synthetic bone substitute relies on bio-inspired design which has a performance level close to that of natural one. In this context, biomedical approaches are considered very important to result bio-functional hybrid for bone substitution purposes. In this study, effect of cross-linking to the mechanical properties of apatite gelatin hybrid has been investigated. Cross-linking was employed by 1-ethyl-3-3-dimethylaminopropyl carbodiimide (EDC) agent. The EDC agent creates a peptide bond between gelatin molecules inside the hybrid to the cross-linked structure. Cross-linked structure of gelatin increases physical property of the hybrid since it can hold the outer forces longer than that of without cross-linking.

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Journal Info
Indonesian Journal of Chemistry
Website

Abbrev

ijc

Publisher

Universitas Gadjah Mada

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry

Description

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology ...