<![CDATA[The aim of this research was to analyze the influence of practical-based learning model on the concept of regulation system of the science process skills and concept comprehension of student. Research method was a quasi-experimental with the matching pretest-posttest design. The research population consisted of all students in class XI in one of senior high school in West Sumatra with a total population of 150 students. Sampling technique was a cluster random sampling. Sample consisted of 26 students of class experiment through practical-based learning and 26 students of class control through verification practical learning. The instrument consist of a science process skills test and concept comprehension test. The data was analyzed using the Mann-Whitney test, Normalized gain. The results showed that there was a significant difference in science process skills and concept comprehension between the experimental and the control class. Herewith, it has been concluded that the practical-based learning model on the concept system of regulation improvement the science process skills and concept comprehension.]]>
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