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INDONESIA
Jurnal Kartika Kimia
Published by Universitas Jenderal Achmad Yani
ISSN : 26551322     EISSN : 26550938     DOI : -
Core Subject : Science, Education, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education
Jurnal Kartika Kimia is National Journal that publish all research article/ review/ short communication related to progres of chemistry researchs. Scope of this journal are: 1) Analytical Chemistry ; 2) Inorganic Chemistry ; 3) Physical Chemistry ; 4) Organic Chemistry ; 5) Biochemistry also applied chemistry such as Material Chemistry, Environmental Chemistry, Catalyst, Food Chemistry, Natural Products Chemistry, and Computational Chemistry. Jurnal Kartika Kimia published by Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University. Jurnal Kartika Kimia publish 2 issues per year at May and November. Jurnal Kartika Kimia can be accessed via print (ISSN 2655-1322) and online (ISSN 2655-0938)
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Articles 10 Documents
 1 
Search results for , issue "Vol 5 No 2 (2022): Jurnal Kartika Kimia" : 10 Documents clear
Docking and Dynamics Studies: Identifying the Binding Ability of Quercetin Analogs to the ADP-Ribose Phosphatase of SARS CoV-2 Arfan Arfan; Rahmat Muliadi; Rachma Malina; Nita Trinovitasari; Aiyi Asnawi
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.143

Abstract

The SARS-CoV-2 coronavirus outbreak has resulted in severe pneumonia, even death (COVID-19). ADP-Ribose phosphatase (ADPR), a highly conserved macrodomain of this virus, was appropriate for viral RNA replication and transcription. According to studies, quercetin suppresses the main protease and 3-chymotrypsin and papain-like proteases, exhibiting antiviral efficacy against SARS CoV-2. However, quercetin analogs to ADPR have yet to be investigated. This study aims to obtain candidate compounds for ADPR based on binding energy, interaction mode, and binding stability using docking and molecular dynamics (MD) studies.The native ligand (AMP) has estimated binding energy based on docking results of -7.35 kcal/mol. Quercetin analogs, lig_C00013871 (Quercetin 3-(2''-galoylrutinoside), lig_C00006532 ([5',5']-Bisdihydroquercetin), and lig_C00013874 (Quercetin 3-(2G-(E)-p-coumaroylrutinoside) has more negative binding energy, with estimates of -9.43, -9.26, and -8.98 kcal/mol, respectively. These results align with binding energy estimates based on MM-GBSA of -14.76, -29.39, -34.90, and -42.79 kcal/mol for AMP, lig_C00006532, lig_C00013871, and lig_C00013874, respectively. According to the MD simulation, lig_C00006532 and lig_C00013874 will be more effective in stabilizing the ADPR complex. Finally, these two analogs are potential candidate compounds as ADPR inhibitors of SARS CoV-2.
Synthesis Study of Amylum-Carboxymethyl and Amylum-Sulfonate to Increase their Solubility in Water Khusna Widhyahrini
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.156

Abstract

Modified starch is synthesized to change the physical and chemical properties, one of which is solubility. Two new things were produced in the starch substitution process, namely modifications in the final stage (workup) of the reaction of each substituent, namely changes in the neutralization stage/carboxymethyl starch solids using 30% CH3COOH and the use of methanol pro-analyst in the starch sulfonate deposition process. The results of the solubility test showed that at room temperature and a concentration of 1.5% g/L, carboxymethyl substituted starch was completely soluble in water, while starch with the same concentration was completely soluble at 30°C. The viscosity test at room temperature resulted in a flow time of 25.02 seconds for starch-carboxymethyl and 10.15 seconds for starch-sulphonate. The a-amylase test was identified by thin layer chromatography (TLC) with the presence of reducing sugar stains on the starch-carboxymethyl hydrolysis product but not on the starch-sulphonate hydrolysis product. The Dinitrosalicylate (DNS) test showed that the amount of reducing sugar of starch sulfonate was much smaller than that of starch-carboxymethyl.
Alkilamida dari Buah Zanthoxyllum acanthopodium (Andaliman) Iqbal Musthapa; Vidia Afina Nuraini; Gun Gun Gumilar; Ristvi Humairo
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.163

Abstract

Senyawa alkilamida tidak jenuh yang dikenal sebagai ZP-amida F telah berhasil diisolasi dari buah tumbuhan andaliman (Zanthoxyllum acanthopodium). Penemuan senyawa ini adalah yang pertama kali pada tumbuhan ini. Penentuan struktur senyawa didasarkan pada data spektroskopi 1H-NMR dan perbandingan nilai geseran kimia dengan standar.
Pungut Ulang Perak dari Limbah Elektronik Baterai Koin Perak Oksida Menggunakan Pelarut Deep Eutectic Oksalin Soja Siti Fatimah; Agung Slamet Nugraha; Abraham Mora
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.165

Abstract

Permintaan perak dunia mencapai 32.627 ton pada tahun 2021. Untuk memenuhi permintaan perak dunia selain menambang dari alam, perak juga bisa didapatkan melalui pungut ulang dari limbah elektronik menggunakan Deep Eutectic Solvent (DES) yang ramah lingkungan. Penelitian ini bertujuan untuk melakukan pungut ulang logam perak dari limbah elektronik baterai koin perak oksida menggunakan metode pelindian dengan DES oksalin. Metode penelitian terdiri dari tahapan sintesis pelarut eutektik oksalin, karakterisasi, dan aplikasinya pada pelindian perak dari limbah elektronik. Pelindian perak dilakukan dengan melarutkan 0,2 gram sampel dalam pelarut oksalin 1:1 dengan pemanasan langsung selama 3 × 8 jam pada pengadukan 500 rpm. Variasi suhu pelindian yang dilakukan adalah 50, 60, 70, dan 80oC dan variasi volume DES oksalin yang digunakan adalah 20, 40, 60, 80, 100, dan 125 mL/g. Konsentrasi perak hasil pelindian diukur menggunakan instrumentasi AAS. Hasil sintesis pelarut dikarakterisasi dengan FTIR menunjukkan terbentuknya interaksi antarmolekul yang baru yaitu interaksi COOH••••Cl. DES oksalin memiliki densitas sekitar 1,2095 g/mL. Berdasarkan hasil optimasi suhu pelindian dengan menggunakan 20 mL/g pelarut didapatkan suhu optimum untuk melakukan pelindian adalah 60oC dengan efisiensi pelindian 88,35%. Sedangkan hasil optimasi volume pelarut yang dilakukan pada suhu optimum didapatkan bahwa volume optimum pelarut yang digunakan adalah 80 mL/g sampel dengan efisiensi pelindian 94,23%. Hasil penelitian menunjukkan DES oksalin berpotensi untuk digunakan sebagai pelarut pada pengolahan limbah baterai bekas perak oksida.
Potential of Corn Stalk Biomass as Biosorbent in Adsorption of Mercury (Hg) Metal Contaminants Muhammad Fathurrahman; Sutanto Sutanto; Yobi Sukresna
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.167

Abstract

Corn stalks are an agricultural waste that is commonly found in Indonesia. Corn stalks have a high enough cellulose content which has functional groups that can be used as biosorbents. This study aims to optimize the adsorption of corn stalk waste to mercury metal ions and then determine the adsorption capacity and adsorption constant of the Langmuir and Freundlich isotherm model. This research begins with corn stalk preparation, delignification, characterization using FTIR and SEM, determination of optimization of biosorbent weight, pH of Hg solution, contact time, and concentration of Hg solution, then applied to mercury metal contamination waste. Optimization of the weight of biosorbent in the range 0.4-1.2 grams, pH of the Hg solution is 2-4, contact time is 60-120 minutes, and concentration of the Hg solution of 30-100 g/L with a solution volume of 50 mL. Furthermore, determination of mercury levels, manufacture of standard series, and testing using ICP-OES. Followed by the determination of Langmuir and Freundlich's adsorption isothermal model. The results of this study indicate that the optimum conditions for the adsorption process occur at the weight of the biosorbent 1.2 grams, pH of the Hg 3 solution, contact time of 90 minutes, and concentration of Hg solution of 40 ppb with a solution volume of 50 mL. The application of biosorbent to metal contamination waste with adsorbed Hg concentration obtained 27.5772 ppb in 50 mL of waste solution with an adsorption efficiency of 88.44%. In the determination of Langmuir and Freundlich isotherms, a match was found for Langmuir adsorption isothermals with an adsorption capacity of 0.00333 mg Hg/g biosorbent and b = 176.8256.
Aktivitas Antioksidan dari Ekstrak Daun Kedondong (Spondias dulcis) Melalui Penangkal Radikal Superoksida Ucu Wandi Somantri; Tarso Rudiana; Prasetyo Alfaridzi Kuncoroyekti
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.168

Abstract

Ambarella (Spondias dulcis) is a tropical plant which is known to have antioxidant activity. This study aims to determine the antioxidant activity of the n-hexane, ethyl acetate and methanol extracts of S. dulcis leaves through superoxide radical scavenging and to characterize the phytochemical compounds in the extract using LCMS/MS. S. dulcis leaf powder was macerated with n-hexane, ethyl acetate and methanol. Antioxidant activity was tested through superoxide radical scavengers. The n-hexane extract of S. dulcis leaves had the best antioxidant activity with an IC50 value of 2080 µg/mL. Based on LCMS/MS, 6 compounds were detected in the n-hexane extract at retention time (Rt) 3.23-9.89 minutes. Compounds Ajmalin, Scopoletin, scoparone, 3-methyl-6-[[2-(2-methylbut-3-en-2-yl)-1H-indole-3-yl] methyldene]piperazine-2,5-dione, [3-hydroxy-3-methylbut-1-enyl]-5,7-dimethoxy-2-phenyl-2,3-dihydrochromene-4-one, and 4-hydroxy-3-(3-methylbut-2-enyl)phenyl ]ethanone.
Valorisasi Bonggol Pisang dengan Polyol dan Kitosan Sebagai Bahan Baku Bioplastik Nila Tanyela Berghuis; Rafkita Shelly; Stanislaus Axel Ajipratama; M. Hasbi Ar-Raihan; Oktaviani Wulandari; Ayu Silvia Fitri
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.171

Abstract

Banana stumps, which are plentiful yet still underutilized, are one of the waste products of the banana harvesting process. Recent research indicates that banana stumps contain up to 76 percent starch. To address environmental issues brought on by the use of disposable plastics, we used starch from banana stumps as bioplastics feedstock. To enhance the performance of bioplastics, experiments with the addition of glycerol, sorbitol, and chitosan were conducted. FTIR spectra of the two bioplastic films indicate that additives do not alter the functional groups of bioplastics because they give equal absorption areas with just varying intensities. The result of the thermogravimetric analysis showed glycerol bioplastics disintegrated more quickly (231.85oC) than sorbitol bioplastics (278.75oC). The water absorption test reveals that glycerol bioplastics are more water-resistant than sorbitol bioplastics. According to the results of the biodegradation test, sorbitol bioplastics break down more quickly than glycerol bioplastics. The tensile strength test of sorbitol-based bioplastics yielded a value of 2.233 N/m2, which is greater than the glycerol-based bioplastics' value of 1.830 N/m2. These results show the banana stump's potential as a feedstock for the manufacturing of bioplastics.
Molecular Docking Studies of Phoenix dactylifera L. Against SARS-CoV-2 ACE-2 Receptor Siti Warnasih; Ade Heri Mulyati; Siti Kholisoh
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.177

Abstract

Dates (Phoenix dactylifera L.) are one of the most useful plants. According to previous research, those dates contain bioactive compounds with antioxidant, antimicrobial, and anti-inflammatory properties. Furthermore, dates can be used as an antiviral, but the potential of dates as an antiviral, particularly the SARS-CoV-2 antiviral, has received little attention. As a result, the goal of this study was to see if date palm bioactive compounds could be used as SARS-CoV-2 antivirals with molecular docking against the Angiotensin-Converting Enzyme-2 (ACE-2) receptor. The study was carried out using molecular docking methods with Autodock Vina, where 21 chemical compounds found in date palms as ligands were attached to the ACE-2 receptor, and four chemical compounds used as SARS-CoV-2 antiviral medicines, namely chloroquine, favipiravir, plitidepsin, and remdesivir, were used as a control ligand. The results showed that proanthocyanidin B1, B2, and quercetin ligands had the highest interaction and stability with Gibbs free energy values of -9.20 kcal/mol, -9.10 kcal/mol, and -8.20 kcal/mol, respectively. This value is known to be higher than control ligands plitidepsin -9.02 kcal/mol, remdesivir -7.88 kcal/mol, chloroquine -5.65 kcal/mol, and favipiravir -5.38 kcal/mol. As a result, dates can be used as a SARS-CoV-2 antiviral candidate.
Thermodynamics Theoretical Investigation for Synthesis of Pyridine from Pyrylium Salt using Density Functional Theory Selmi F. Khoiriah; Agil Aprianto; Putri Kania; Rafi N. Fauzi; Mita Nurhayati
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.178

Abstract

Pyridine is a heterocyclic compound that is widely used as an ingredient in medicines, vitamins, food flavors, pesticides, dyes, adhesives, and others. Currently, pyridine synthesis is carried out with coal tar as a raw material, which is a non-renewable natural resource. In this research, a theoretical study was carried out to evaluate the synthesis process of pyridine using pyrylium salt as an alternative raw material to displace coal tar. This study also aims to simulate the pyridine synthesis and the energy required or released in the process. Density Functional Theory (DFT) method was employed to calculate some thermodynamic properties of the species involved in the reaction such as enthalpy, entropy, and Gibbs free energy in a vacuum and solvated model in order to study the progress of the reaction and mechanism. Based on the calculation results, the lowest value of enthalpy, entropy, and free energy Gibbs is obtained when the reaction takes place in a vacuum. The change of entropy and free Gibbs energy of the reaction was not predominantly affected by the degree of polarity of the solvent. Meanwhile, the enthalpy of reaction simulated in water solvent is higher than in the ethanol solvent. The synthesis reaction of pyridine from pyrylium salt is exothermic and exergonic because it has a negative value of enthalpy change and Gibbs free energy at 298.15 K, which is potential to be done at room temperature without extreme condition control.
Characteristics and Antioxidant Activity of Nanoparticles Chitosan Roselle (Hibiscus sabdariffa) Retno Diyah Utari; Budi Saputra; Randi Kristiana; Tiani Yunita; Valentina Adimurti Kusumaningtyas; Jasmansyah Jasmansyah
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.180

Abstract

Roselle (Hibiscus sabdariffa) contains flavonoids with antioxidant activity. The present study aimed to examine the characteristics and antioxidant activity index (AAI) of roselle extract (RE) after being modified into nanoparticles chitosan of roselle (NCR). Phytochemical screening indicated that roselle extract contains flavonoids, saponins, tannins and steroid/triterpenoids compounds. The NCR was prepared using a bottom-to-up method from a cross-link reaction between chitosan and tripolyphosphate. The ratio of RE:Chitosan:Tripolyphosphate was 2:1:0.1. NCR characterization showed 464.6 nm of a particle size, 0.849 of a polydispersion index and -6.0 mV of a zeta potential. Antioxidant activity was measured by utilizing the DPPH method (2,2-diphenyl-1-picrylhydrazyl), with a UV-Vis spectrophotometer at a wavelength of 515 nm. IC50 data were analyzed using the One Way Annova test with a confidence level of 95%. Results showed that NCR had an IC50 value of 22.577 ppm (AAI:2.217), which is classified as a very strong antioxidant. The IC50 value of the RE was 77.610 ppm (AAI:0.644), which is categorized as a moderate antioxidant. The results of this study reveal that the modification of roselle extract (RE) into nanoparticles chitosan of roselle (NCR) was proven to enhance the AAI (p<0.05).

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