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Journal of Pharmaceutical and Medicinal Research Sekolah Tinggi Ilmu Farmasi Makassar Perintis Kemerdekaan Street KM 13.7 90242 Makassar-Indonesia
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Journal of Pharmaceutical and Medicinal Sciences
Published by Sekolah Tinggi Ilmu Farmasi Makassar
ISSN : 25282824     EISSN : 2580328X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Journal of Pharmaceutical and Medicinal Sciences (JPMS) pISSN 2528-2824; eISSN 2580-328X dedicated to publish original research papers, original research notes, invited topical reviews, mini-reviews, editorial commentary and news. Medicinal resources about exchange of information and understandings about people's use of plants, fungi, animals, microorganisms, minerals, their biological and pharmacological effects based on the principles established through international conventions. Pharmaceutical including drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology and targeted drug delivery.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 3 No 2 (2018): JPMS" : 5 Documents clear
Variasi Konsentrasi Ekstrak Mahkota Bunga Kasumba Turate (Carthamus tinctorius L.) dan Ekstrak Etanol Umbi Bawang Dayak (Eleutherine palmifolia) sebagai Imunostimulan Yuri Pratiwi Utami
Jurnal Farmasi dan Ilmu Pengobatan Vol 3 No 2 (2018): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v3i2.69

Abstract

Fagocytosis is a process characterized by phagocytic cells ingesting good, pathogenic foreign cells commonly carried out by macrophages. This study aimed to determine the phagocytic activity of a combination of crown extract of turate kasumba (Carthamus tinctorius L.) and dayak onion tuber extract (Eleutherine palmifolia) as immunostimulant. The study was experimental, the number of mice used in the test was 21 individuals and randomly divided into 7 groups (n = 3); K1 was given C. tinctorius extract 1% w/v; K2 was given E. palmifolia extract 2% w/v; K3 was given E. palmifolia extract 4% w/v; K4 and K5 was given syrup combination C. tinctorius and E. palmifolia extract = 1 : 2 and 1 : 4% w/v; K6 was given Stimuno®; while K7 as negative control. Phagocytic activity was carried out on the 11th day using the carbon cleaning method. The results showed that the highest phagocytic activity was shown by K4 significant (p <0.05) on K1, K2, K3, K5, K6, and K7. This shows that K4 has better immunostimulatory activity than other groups.
Uji Aktivitas Hipoglikemik Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Terhadap Mencit (Mus musculus) Yang Diinduksi Aloksan Zulham Zulham; Wahyu Hendrarti; Nurul Wahyuni
Jurnal Farmasi dan Ilmu Pengobatan Vol 3 No 2 (2018): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v3i2.70

Abstract

Diabetes mellitus (DM) is a chronic disorder that specifically involves the metabolism of carbohydrates (glucose) in the body, also causes disorders of fat and protein metabolism. The benefits of kersen (Muntingia calabura L.) which are well known, among others, overcome DM. This study was conducted to determine the hypoglycemic activity of ethanol extract of M. calabura leaves in reducing blood sugar levels and effective dose of reducing blood glucose in mice (Mus musculus) induced by alloxan 130 mg/kg BW. Distribution of experimental animals, group I was given a glibenclamide suspension 0.13 mg/kg BW as (positive control), groups II, III and IV were given ethanol extract of M. calabura leaves at a dose of 50, 100 and 150 mg/kg BW and the group V is given a 1% NaCMC suspension (negative control). Giving extracts carried out for 7 days. The results showed blood sugar levels before treatment, after induction, and after treatment, respectively, group I (81.00; 141.00; and 94.75 mg/dL), group II (79.00; 138.50; and 50.00 mg/dL), group III (102.50; 119.25; and 77.75 mg/dL), group IV (88.25; 146.00; and 61.00 mg/dL), and group V (108.00; 131.25; and 114.75 mg/dL). Based on the results of the study showed a decrease in blood sugar levels at all doses of ethanol extract of M. calabura leaves which has the potential as a diabetes drug.
Uji Aktivitas Ekstrak Bunga Brokoli (Brassica oleocera L. var italica), Wortel (Daucus carota L.) dan Cabai Merah (Capsicum annum L.) Sebagai Penghambat Kolagenase Aisyah Fatmawaty; Angriani Angriani
Jurnal Farmasi dan Ilmu Pengobatan Vol 3 No 2 (2018): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v3i2.71

Abstract

Collagenase is an enzyme family of Matrix Metalloproteinase (MMP) that breaks down collagen and degrade the extracellular matrix resulting in wrinkles and changes in skin thickness. This study was aimed to determine the value of inhibition concentration of flower extracts of broccoli (Brassica oleocera L. var Italica), carrot extract (Daucus Carota L.) and extract of chili pepper (Capsicum annuum L.) as collagenase inhibitor. Collagenase inhibitory activity was determined by measuring the product resulted from the reaction of enzyme and substrate using a microplate reader at λ 345 nm. Results showed that the inhibition of the flowers of broccoli, carrot and chili pepper ekstrak were 88.49%; 53.96% and 89.21% at a concentration of 250 ug / ml.
Isolasi dan Karakterisasi Senyawa Steroid dari Ekstrak Aseton Daun Faloak (Sterculia quadrifida R.Br) Burhanuddin Taebe; Imrawati Imrawati; Cindy Nuradzani Rachman
Jurnal Farmasi dan Ilmu Pengobatan Vol 3 No 2 (2018): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v3i2.72

Abstract

Faloak leaves (Sterculia qudrifida R.Br) has been used by Aborigine ethnic to treat insect bites, cuts, arrowheads, stinging wounds and injury. This study was aimed to isolate and characterize the steroid compounds from the acetone extract of faloak leaves. Extraction by maceration method use acetone as solvent than acetone extract was partitioned again with n-hexane and ethyl acetate. The steroids positive fraction was separated using preparative thin layer chromatography and thin layer chromatography 2 dimensions for testing the purity. The isolate was characterized using FT-IR. The results of spectroscopic analysis FTIR show that isolates suspected were steroids compounds with functional group C=O, C- O, C=C, C-C, and C-H.
Explorasi Fungi Endofit Dari Tanaman Bunahong (Andredera cordifolia (Ten.) Steenis) Sebagai Penghasil Kandidat Senyawa Antibakteri Ismail Ismail; Megawati Megawati; Nur Fadillah Bakri
Jurnal Farmasi dan Ilmu Pengobatan Vol 3 No 2 (2018): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v3i2.68

Abstract

Binahong leaves (Andredera cordifolia (Ten.) Steenis) contain triterpenoid saponins, flavonoids and phenyl propanoid which have antibacterial activity. One source of the antibacterial bioactive compounds is endophytic fungi, are symbiotic microorganisms in plant tissues found in A. cordifolia leaves. This study aims to isolate endophytic fungi from A. cordifolia leaves and their activity against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 83125. The stages in this study included isolation of endophytic fungi, purification, test antagonists, metabolite production and active liquid fermentation tests on test bacteria. The results of this study were 9 endophytic fungi isolates with different characteristics. Of the nine isolates, the best isolates were given in isolation, I8 and I9 isolates with an average inhibitory diameter of 10 mm for Escherichia coli and Staphylococcus aureus.

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