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Amin Fatoni
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INDONESIA
Molekul: Jurnal Ilmiah Kimia
Published by Universitas Jenderal Soedirman
ISSN : 19079761     EISSN : 25030310     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue "Vol 2, No 2 (2007)" : 7 Documents clear
ISOLASI DAN IDENTIFIKASI SENYAWA KIMIA SERTA UJI AKTIVITAS ANTICANDIDAISIS SERBUK BATANG SIRIH DUDUK (Piper sarmentosum Roxb. Ex Hunter) Suwandri Suwandri; Hartiwi Diastuti; Purwati Purwati
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (122.57 KB) | DOI: 10.20884/1.jm.2007.2.2.33

Abstract

Sirih duduk or Piper sarmentosum Roxb. ex Hunter have been long used the people in Indonesia for traditional medicine to cure various diseases. One of them was used to treat fungoid diseases. This research was aimed to examine the anticandidaisis activity from extract of P. sarmentosum bark, isolate and identify anticandidaisis compounds from P. sarmentosum bark. The isolation of bioactive compounds of P. sarmentosum bark was performed by extraction the powder of P. sarmentosum bark using methanol. The methanol extract was then fractionated using n-hexane, chloroform and ethylasetat. The fractions respectively was examined their activity against C. albican. The active extract was then fractionated performed by coloumn chromatography and was then separated performed by thin layer chromatography. Identification of bioactive compound was carry out using gas chromatography-mass spectrometry (GC-MS). The results show that chloroform, ethylasetat and methanol extracts of P. sarmentosum have more activities against C. albicans than miconazol. Bioactive compound from extract of P. sarmentosum bark was bis(2-ethylhexyl)phtalat.
BIODEGRADASI POLIETILENA MENGGUNAKAN BAKTERI DARI TPA (TEMPAT PEMBUANGAN AKHIR) GUNUNG TUGEL KABUPATEN BANYUMAS Zusfahair Zusfahair; Puji Lestari; Dian Riana Ningsih; Senny Widyaningsih
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.89 KB) | DOI: 10.20884/1.jm.2007.2.2.39

Abstract

Plastic has high potency to become material that much threats human living in this earth, because made from chemical which cannot degraded by microbes in environment. The successful production and marketing of biodegradable plastics will help alleviate the problem of environmental pollution. One of biodegradable plastic that used in our live is polyethylene. This research reveals that local microbes capable to degrading of polyethylene. Biodegradation test was carried out by using bacteria in soil which was obtained from Gunung Tugel disposal center, Banyumas regency. Kind of polyethylene is LDPE (Low Density Polyethylene) which was obtained from Setiakawan Plastic Factory, Kalibogor, Purwokerto formed to thin film. Characterization of the polyethylene used weight loss percentage method, melting point determination and FTIR. Soil bacteria isolated from Gunung Tugel disposal center, Banyumas regency, obtained 5 single colonies, which coded GT. Bacteria isolate which have highest activity in degrading polyethylene was GT 3, with increasing the time of incubation. Weight loss percentage up to 2.33% in 1 month. Melting point of polyethylene after biodegradation was decreased that initially 210-220 °C into 210-213 °C. FTIR spectrophotometer result of polyethylene after biodegradation showed intensity for methylene and methyl cluster was decreased.
PEMODELAN SENYAWA TURUNAN ASAM KARBAMAT SEBAGAI SENYAWA ANTIKANKER MENGGUNAKAN METODE SEMIEMPIRIS AM1 Senny Widyaningsih; Purwati Purwati; Riyadi Riyadi
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (227.998 KB) | DOI: 10.20884/1.jm.2007.2.2.34

Abstract

4-N-carbamic acid-4’-dimetylpipodopylotoxin and its derivatives are compounds which are synthesized from etoposide (VP 16). These compounds are used as anticancer medicine because they inhibit DNA topoisomerase II enzyme. The enzyme participates in controlling breaking process of DNA double helix bounding in cancer cell. It makes cancer growing cease and dies because cell can not replicate. However, the compound insoluble in water, make a medicine resistant, inhibit metabolism system and poison. It needs to design a modification of new compounds from carbamic acid derivatives which have higher activity. Structure modification was done using Quantitative Structure Activity Relationship (QSAR) which was a computational chemistry application in medicine design process. This research used semiempiris AM1 method to determine the best QSAR equation based on multilinear regression analysize, with log 1/IC50 as dependent variable and independent variables were atomic net charge of qN29, qC30, qO31, qO32, dipole moment, n-octanol-water coefficient partition (Log P), and polarity. The best QSAR equation in this research was : Log 1/IC50 = 4.871 + 12.738 qN29 + 33.183 qC30 + 28.015 qO31 – 3.6 x 10-2 polarity, with N = 13, r =0.907, SE = 0.13025, Fcount/Ftable = 1.901, PRESS = 0.1357. Based on the best QSAR equation, the prediction compounds were 1, 2, 3, 8, and 22 with each IC50 theoretical value were 0.032, 0.034, 0.036, and 0.098 µM.
PREPARASI DAN KARAKTERISASI KITIN DARI KULIT UDANG PUTIH (Litophenaeus vannamei) Mardiyah Kurniasih; Dian Windy Dwiasi
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (295.624 KB) | DOI: 10.20884/1.jm.2007.2.2.36

Abstract

Chitin is one of the most abundant natural polysaccharides produced by many living organisms; it is usually found as a component of crustacean shells. In this paper, Chitin have been isolated from white shrimp (Litophenaeus vannamei). The preparation of chitin using chemical products to deproteinize and demineralize the source material. Characterization included determination of water, ash, fat and protein degree; moreover chitin powder characterize with FTIR and XRD spectroscopy. The result showed that process efficiency of chitin from white shrimp (Litophenaeus vannamei) was 20.95%, with degree of water, ash, fat and protein were 5.39, 2.66, 1.54 and 36.16%, respectively.
ANALISIS KANDUNGAN MINERAL BERPOTENSI TINGGI PADA PASIR GALIAN DI WILAYAH KABUPATEN BANYUMAS Zaroh Irayani; Bilalodin Bilalodin
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (132.111 KB) | DOI: 10.20884/1.jm.2007.2.2.37

Abstract

It have been done analysis high potential mineral contents of sands and sandstone in Banyumas region. Sands and sandstone are taken from mining traditional at rivers and river’s stone grinder place. Sand samples were taken from Tajum, Logawa, Serayu and Klawing river, while sandstone were taken from Banjaran, Logawa and Klawing river’s grinder place. Sand was separate using permanent magnet to disassociated the magnetic and non magnetic mineral content and analyzed by X-ray difraction to reveal the mineral types. The Result indicated that river sand contained 39% magnetic mineral and 61% non magnetic. While identification using X-ray difraction obtained that sand have mineral of complex structured of valuable element such as Fe, Ti, Si and Zn and also rare earth like Y, Ca, Li and La.
PENURUNAN KADAR ZAT WARNA RODAMIN B MENGGUNAKAN HUMIN HASIL ISOLASI DARI TANAH HUTAN DAMAR BATURRADEN Tien Setyaningtyas; Roy Andreas
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.973 KB) | DOI: 10.20884/1.jm.2007.2.2.35

Abstract

Humin was isolated from the Baturraden resin forest and purified use mixture of HCl:HF. Purified humin is characterised such as identify of functional group of humin, stipulating of water content, stipulating of dust content, obstetrical stipulating of total acidity content, carboxylic and OH phenolic functional group. The adsorption of rodamin by humin measured by UV-Visible spectrophotometer at maximum wavelength of rodamin B liquid, optimum pH and optimum contact time to determine absorbtion capacities and isotherm adsorption pattern .Humin that isolated from Baturraden resin forest have characteristic such as water content 16.6199 %; dust content 9.2050 %; total acidity content 475 cmol / Kg; carboxylic rate 200 cmol/Kg, and OH phenolic rate 275 cmol/Kg. Maximum wavelength of rodamin B is 554 nm and optimum contact time of adsorption rodamin B by humin is 180 minute with optimum pH 4. Adsorption rodamin B by humin follows the pattern of Langmuir isotherm adsorptionwith the value of R2 is 0.9801 and absorption capacities is 39,5257 mg/g.
PENENTUAN KEASAMAN ZEOLIT MENGGUNAKAN METODE GRAVIMETRI, TITRASI DAN FTIR Dwi Kartika; Mardiyah Kurniasih
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (70.057 KB) | DOI: 10.20884/1.jm.2007.2.2.38

Abstract

Determination of natural zeolite and activated natural zeolite acidity using gravimetric, titration and FTIR methods had been carried out. The result of gravimetric method show that the acidity of the natural zeolite and activated natural zeolite was 2,350 and 5,628 mol/gram, respectively. The titration method can be obtained that the acidity degree of the natural zeolite and activated natural zeolite was 12,333 and 12,067, respectively. The result showed that the activation of the natural zeolite sample by HCl caused dealumination.

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