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JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Published by Universitas Airlangga
ISSN : 19073623     EISSN : 26849453     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Juxta (Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. Juxta provides a forum for original article to the editor and it will be published Two-times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in Juxta.
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Articles 12 Documents
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Search results for , issue "Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga" : 12 Documents clear
The Effectiveness of Meloxicam Adjuvant Therapy to Improve Cognitive Function of Schizophrenic Patients Nabila Nur Bilqis Islamy; I Gusti Bagus Indro Nugroho; Adriesti Herdaetha
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.52-56

Abstract

Highlights:1. Schizophrenic patients have cognitive dysfunction.2. Meloxicam, as an adjuvant therapy, can improve cognitive function in schizophrenic patients. AbstractIntroduction: Schizophrenia is a chronic psychotic disorder triggered by genetic and environmental factors such as an inflammatory response. The inflammatory response in schizophrenic patients increases with cognitive decline. Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) group with Cyclo-oxygenase (COX-2) inhibitory activity and can suppress the production of inflammatory cytokines. This study aimed to determine the efficacy of Meloxicam as an adjuvant therapy to improve cognitive function in schizophrenic patients.Methods: This was a quasi-experimental study using a single-blind, pretest–post-test design. The sample size in this study was 34 subjects who had met the inclusion and exclusion criteria. All samples were divided into two groups, namely the treatment group, with as many as 17 subjects receiving additional therapy with Meloxicam 15 mg/day for 4 weeks, and the control group, with 17 subjects. The score of the Schizophrenia Cognition Rating Scale (ScoRS) was assessed before and after therapy. Data analysis used SPSS 25.0. In both groups, the SCoRS score was different.Results: In the treatment group, there was a decrease in the SCoRS score that was greater than in the control group. There was a statistically significant difference with p = 0.002 in decreasing SCoRS scores.Conclusion: In the treatment group, there was a decrease in the SCoRS score that was greater than in the control group. There was a statistically significant difference with p = 0.002 in decreasing SCoRS scores.
The Differences in Adjuvant Therapy Effectiveness Meloxicam and N-Acetylcysteine against Negative Symptoms of Schizophrenia Banu Kadgada Kalingga Murda; I Gusti Bagus Indro Nugroho; Adriesti Herdaetha
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.63-69

Abstract

Highlights:1. Schizophrenic patients can have negative symptoms.2. Adjuvant therapy is needed to assist antipsychotics in reducing the negative symptoms of schizophrenic patients. AbstractIntroduction: Meloxicam and N-Acetylcysteine are examples of drugs with anti-inflammatory effects that have been widely studied, and are considered to reduce negative symptoms of schizophrenia. Both of these drugs are also widely available in Indonesia and can be obtained at an affordable price. This study aimed to analyze the differences in the effectiveness of adjuvant therapy meloxicam and N-Acetylcysteine on negative symptoms of schizophrenic patients. Methods: This was a quasi-experimental study using a single-blind, pretest–post-test design. Determination of the subject used a purposive sampling technique according to the inclusion criteria. This study examined 34 samples and divided them into two groups. In group A, 17 subjects received adjuvant meloxicam therapy of 15 mg/day for 4 weeks; in group B, 17 subjects received adjuvant therapy of N-Acetylcysteine 400 mg/day for 4 weeks. Score assessment was performed using the positive scale, negative scale, and general psychopathology scale (PANSS) negative subscale pre- and post-therapy, then compared the effectiveness. Data analysis used SPSS 25.0.Results: The mean score of the PANSS post-test subscale was negative in the meloxicam adjuvant therapy group 15.58, while for the N-Acetylcysteine adjuvant therapy group was 17.64 with a p-value of 0.009. The mean decrease in the negative subscale PANSS score in the meloxicam adjuvant therapy group was 11.00, while the N-Acetylcysteine adjuvant therapy group was 19.70 with a p-value of 0.000.Conclusion: There was no difference in the effectiveness of adjuvant therapy meloxicam and N-Acetylcysteine in improving negative symptoms of schizophrenic patients.
The Effectiveness of Meloxicam Adjuvant Therapy against Negative Symptoms and Neutrophil Lymphocyte Ratio (NLR) in Schizophrenic Patients Katarina Bernadet Dinda Sekar Melati; Adriesti Hardaetha; Wijaya Kusuma
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.57-62

Abstract

Highlights:1. The NLR value can show the role of neuroinflammation in schizophrenic patients.2. Meloxicam as adjuvant therapy can improve negative symptoms and changes in the NLR in schizophrenic patients. AbstractIntroduction: Neutrophil-lymphocyte ratio is a simple and affordable marker of inflammation that has recently been widely used to assess systemic inflammation in psychiatric patients. This study aimed to determine and analyze the effectiveness of meloxicam as adjuvant therapy to improve negative symptoms and changes in the neutrophil-lymphocyte ratio (NLR) in schizophrenic patients. Methods: This was a quasi-experimental study using a single-blind, pretest–post-test design. Subjects were determined using a purposive sampling technique based on inclusion criteria. This study examined 34 samples and divided them into two groups. The treatment group consisted of 17 subjects who received adjuvant therapy with meloxicam 15 mg/day for 4 weeks and 17 subjects in the control group. Data collection was obtained from medical records, interviews, field notes, positive scale, negative scale, and general psychopathology scale (PANSS) assessment sheets, and blood NLR examinations. Data analysis used SPSS 25.0.Results: The negative subscale PANSS score in the treatment group decreased lower than in the control group, with p-value = 0.640. However, the decrease in NLR values was more significant in the treatment group than in the control group, with p-value = 0.094. There was a decrease in the negative subscale PANSS scores and clinical NLR scores, but it was not statistically significant.Conclusion: Adjuvant therapy with Meloxicam, given once a day for four weeks, had an effect on decreasing the negative subscale PANSS score and NLR scores for schizophrenic patients at Dr. Arif Zainudin Regional Mental Hospital (RSJD), Surakarta, clinically, but it was not statistically significant.
Effectiveness of Adjuvant Treatment of N-Acetylcysteine on Negative Symptoms and Neutrophil-Lymphocyte Ratio (NLR) in Schizophrenic Patients Ipak Ranto; Adriesti Herdaetha; Wijaya Kusuma
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.70-75

Abstract

Highlights:1. The essence of schizophrenia is the negative symptoms.2. Adding meloxicam can improve the negative symptoms and changes in the NLR in schizophrenic patients. AbstractIntroduction: Schizophrenia is a mental disorder that has a negative symptom domain. Negative symptoms are commonly referred to as the essence of schizophrenia. Treatment of negative symptoms is still considered less than optimal. The ratio of neutrophils and lymphocytes is one of the markers of inflammation. This study aimed to analyze the effectiveness of N-acetylcysteine as adjuvant therapy for improving negative symptoms and changes in the neutrophil-lymphocyte ratio (NLR) in schizophrenic patients. Methods: This was a quasi-experimental study using a single-blind, pretest–post-test design. The subjects were 34 schizophrenic patients who were inpatients at Dr. Arif Zainuddin Regional Mental Hospital (RSJD), Surakarta, from May to July 2020. The subjects were assigned using a purposive sampling technique based on inclusion criteria and received adjuvant N-acetylcysteine therapy at 400 mg/day for 4 weeks. Data collection was obtained from medical records, interviews, field notes, positive scale, negative scale, and general psychopathology scale (PANSS) assessment sheets, and blood NLR examinations. Data analysis used SPSS 25.0.Results: There was a significant difference between the treatment and control groups in reducing negative PANSS subscale measurement after adjuvant N-acetylcysteine treatment. However, there was no significant difference between the control and treatment groups after N-acetylcysteine administration for NLR.Conclusion: The dose of adjuvant therapy N-acetylcysteine given to patients in this study had an effect on decreasing the negative subscale PANSS score.
Investigation of Borax in Meatball Products Sold in Bengkalis, Riau Anjeli Cristina Zachawerus; Sulistiawati Sulistiawati; Ema Qurnianingsih
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.89-93

Abstract

Highlights:1. Borax is still used as a food additive even though it has been banned.2. There was no relationship between age, income, and knowledge of the meatball sellers and the use of borax in Bengkalis.3. The risk factors for the widespread use of borax are still unknown. AbstractIntroduction: Borax is a food additive that can no longer be used. However, there were still many street food vendors who violated this rule. This study aimed to determine the presence or absence of borax in meatballs and the relationship between meatball sellers' characteristics and knowledge of the use of borax in Bengkalis, Riau.   Methods: This was an observational analytic study with cross-sectional collection. This study collected 40 samples of meatballs and meatball sellers in Bengkalis. The sampling technique used purposive sampling by interviewing meatball sellers and filling out the questionnaire on the spot. Data were analyzed by Chi-Square test.Results: This study found that all meatballs contained borax with 36 samples found to have borax content above the standard. This study also found no relationship between characteristics (age, level of knowledge, income) and knowledge of meatball sellers with the use of borax (p > 0.05).Conclusion: There was no significant relationship between borax use and meatball sellers' knowledge and characteristics.
Conventional Radiological Profile of Metastatic Bone Disease Based on Its Histopathological Results: A 3-Year Experience Braven Armando; Rosy Setiawati; Mouli Edward; Sjahjenny Mustokoweni
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.76-82

Abstract

Highlights:1. The incidence of MBD tends to be more frequent in older ages and in female patients.2. The radiological appearance of a lesion tends to differ depending on its primary tumor.3. Pathological fracture was present in 55.37% of the cases. AbstractIntroduction: Metastasis commonly occurs in the bone, termed metastatic bone disease (MBD). Early diagnosis and intervention are important to prolong and increase the quality of life. Although conventional radiology is less sensitive for diagnosing this disease, it remains the most cost and time-efficient screening method. This study aimed to describe the radiological profile of patients diagnosed with MBD based on its histopathological result.Methods: This was a descriptive retrospective study using medical records and digital radiological data of patients diagnosed with MBD from 2019-2021 in Dr. Soetomo General Academic Hospital, Surabaya. Variables in this study include gender, age, histopathological result, location of metastases, number of lesions, lesion density, and pathological fracture.Results: 51 patients were diagnosed with MBD during the period of the study and sorted into 121 cases based on metastases location. MBD is more frequent in older female patients, where lesion mostly originates from the breast, thyroid, and lungs, with adenocarcinoma as the most common histology. Vertebrae were the most common location of metastases. Most lesion tends to be multiple and osteolytic. However, certain lesions from different primary tumor had different predilections. Pathological fracture was present in 55.37% of cases.Conclusion: MBD needs to be suspected in patients with cancer from the breast, thyroid, and lungs as its incidence is higher. More studies about MBD profiles on a larger scale should be conducted to better represent this disease in the general population.
Profile of Endometrial Cancer Patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia Kenny Dion Alim; Brahmana Askandar Tjokroprawiro; Etty Hary Kusumastuti
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.83-88

Abstract

Highlights:1. Endometrial cancer is one of the most common cancers that affect the female genitalia.2. Endometrial cancer patients are mostly women in the age group of 51-60 years old, nullipara, with normal BMI, had type 1 endometrial cancer, and on stage II. AbstractIntroduction: Endometrial cancer is one of the most common cancers that affect the female genitalia. This study aimed to find the profile of endometrial cancer patients in Dr. Soetomo General Academic Hospital, Surabaya, from January 2019 to December 2020. Methods: Data were collected from medical records of endometrial cancer patients in Dr. Soetomo General Academic Hospital, Surabaya, from January 2019 to December 2020. There were 154 endometrial cancer patients, and 66 met the inclusion and exclusion criteria. Forty-one of those patients also had curettage grades. Data were extracted from the medical records of those patients.Results: There were 66 samples used in this study. The most common age group of patients was the age group of 51-60 years old (40.91%). The highest parity rate was nullipara (28.79%). The highest body mass index (BMI) group was the normal BMI group (42.42%). The most common type of endometrial cancer was type 1, with endometrioid adenocarcinoma (93.94%). The most common stage of endometrial cancer was stage II (36.36%). The similarity between curettage and post-operative grade was 70.73%. Patients with a history of diabetes mellitus were 6.06%, and patients with a history of hypertension were 12.12%.Conclusion: Most of the endometrial cancer patients in Dr. Soetomo General Academic Hospital, Surabaya, were women in the age group of 51-60 years old, nullipara, with normal BMI, had type 1 endometrial cancer, and on stage II. Most patients had similar curettage and post-operative grades, and only a minority had diabetes mellitus and hypertension histories.
Urinalysis Profile of Dengue Viral Infection Patients in Dr. Soetomo General Academic Hospital, Surabaya, from 2019-2021 Albertus Reiner Rahardjo; Puspa Wardhani
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.94-99

Abstract

Highlights:1. Dengue viral infection patients were mostly male and aged 17-45 years old.2. Dengue viral infection patients mostly have normal urinalysis results.3. Some dengue viral infection patients can have elevated protein, blood, bilirubin, urobilinogen, leukocytes esterase, and ketones in the urine. AbstractIntroduction: Dengue viral infection is still a burden in Indonesia. It often causes some kidney complications such as acute renal failure, proteinuria, hematuria, and glomerulonephritis. Urinalysis is an easy and useful examination of kidney complications. This study aimed to discover the most common profile of urinalysis in dengue viral infection.  Methods: This study used a cross-sectional method with medical records data of patients with dengue viral infection in Dr. Soetomo General Academic Hospital, Surabaya, in the 2019-2021 period. Purposive sampling techniques were used with inclusion and exclusion criteria. Data such as age, gender, dengue viral infection severity level, and dipstick urinalysis results were taken and analyzed using descriptive analysis in SPSS Statistics 25.Results: A total of 276 patients were included. The sample was dominated by male patients (52.9%) and patients aged 17-45 years old (40.2%). Most patients suffered from dengue hemorrhagic fever/DHF (54.3%) followed by dengue fever (45.7%). DHF was categorized into grade I (28.3%), grade II (13.4%), grade III (8.3%), and grade IV (4.3%). Most urinalysis results were normal and followed by increased results of protein, blood/hemoglobin, bilirubin, urobilinogen, leukocytes esterase, and ketones in some patients.Conclusion: Dengue viral infection was more common in male patients and 17-45 years old patients. The most common diagnosis was DHF. Urinalysis results in dengue viral infection were mostly normal. Follow-up research is needed to find the relation between the elevated urinalysis results and the severity of dengue viral infection.
Evaluation of Bowel Function on Patient Post Operative Hirschsprung Disease Ailsa Reina Faradiba; Alpha Fardah Athiyyah; I Gusti Bagus Adria Hariastawa
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.105-110

Abstract

Highlights:1. All HD patients have good defecation quality after surgery.2. Almost all HD patients can control bowel movements without constipation or social problems after surgery.3. The most common problem patients face after surgery is soiling, which sometimes requires diapers. AbstractIntroduction: Hirschsprung's disease (HD) is a congenital disease in which Meissner and Auerbach's plexus ganglion cells are lost on the distal side of the digestive tract, thus interfering with defecation. The postoperative defecation process was assessed to describe the patient's quality of life. This study aimed to describe the quality of defecation in pediatric HD patients after surgery. Methods: This was a descriptive study on pediatric PD patients who received surgery in Dr. Soetomo General Academic Hospital, Surabaya, from 2018 to 2021. Demographic data came from Dr. Soetomo General Academic Hospital, Surabaya. The incontinence evaluation was assessed using the Rintala Score.Results: A total of 14 pediatric HD patients underwent definitive surgery and had good scores on the Rintala score. There were 2 (14.3%) patients with maximum scores, 6 (42.9%) patients with normal scores, and 6 (42.9%) patients with good scores. The highest distribution in patients was always being able to hold bowel movements (81.8%), uncertain in reporting the desire to defecate (40.9%), 1-2 times a day (68.2%), never dirty (54.5%), never constipated (77.3%), and had no social problems (77.3%).Conclusion: Pediatric HD patients had a good outcome after a definitive operation. The most common demographics with high satisfaction rates were male and female patients with normal nutritional status, above one-year-old, normal birth weight, and term labor.
Cavendish Banana Peel Extract’s Antibacterial Activities Potential as Disinfectant Erlangga Lazuardi Ramadhan; Wiwin Retnowati; Linda Dewanti; Manik Retno Wahyunitisari
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.100-104

Abstract

Highlights:1. The COVID-19 pandemic makes personal hygiene more important than ever, and antibacterial substances such as disinfectants are crucial in maintaining said hygiene.2. The MBC of cavendish banana peel extract against the growth of bacteria Escherichia coli and Staphylococcus aureus was 25%, with no activity against Bacillus subtilis.3. Musa acuminata peel extract has the potential to be used as a disinfectant. AbstractIntroduction: The COVID-19 pandemic makes personal hygiene more important than ever, and antibacterial substances such as disinfectants are crucial in maintaining said hygiene. This study aimed to determine the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of cavendish banana peel extract (Musa acuminata) against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis.    Methods: The design of this study was a laboratory experiment that used the broth dilution method with test tubes using methanol as the extract’s solvent. Sterile aquadest was used as the solvent, and Mueller-Hinton broth was used as the growth medium in tubes. All samples of the bacteria (Staphylococcus aureus, Escherichia coli, and Bacillus subtilis) were provided by the Laboratory of Microbiology Faculty of Medicine, Universitas Airlangga.Results: MBC was the only parameter found due to the color and particulates, which hindered the turbidity assessment of MIC. From the dilution test, the MBC of cavendish banana peel extract against the growth of bacteria Escherichia coli and Staphylococcus aureus was 25%, with no activity against Bacillus subtilis.Conclusion: There were antibacterial activities of Musa acuminata peel extract against Staphylococcus aureus and Escherichia coli. Therefore, it has the potential to be used as a disinfectant.

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