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Nursalam Hamzah
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universitas Islam Negeri Alauddin Makassar, Indonesia
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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 8 Documents
 1 
Search results for , issue "Vol 3 No 1 (2020)" : 8 Documents clear
Physicochemical Properties of Palm Oil Fraction (Elaeis guineensis Jacq) Haeria Doloking; Mukhriani Mukhriani; Muh Rusdi; Silmi Rafi’ah; Fadhilah Fitriana
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.14036

Abstract

Study about physicochemical properties of olein and stearin fraction of palm oil has been conducted. Research aim was to determine the chemical physical properties of the olein and stearin fractions of palm oil (Elaeis guineensi Jacq) that was originated from North Mamuju, West Sulawesi. Palm oil was fractionated by dry fractionation method to collect the olein and stearin fractions. The physical chemical characteristics of fractions were determined by acid value, saponification value, peroxide value, and iodine value parameters that measured by titrimetry method. The result of analysis showed that the acid values for the olein and stearin fractions acid were 7.04 and 5.83 mg NaOH/g, saponification values were 198.53 and 194.71 mg KOH/g, peroxide values were 0.77 mek O2/kg and 0.79 mek O2/kg, and iodine values were 34.12 and 32.87 g iod/100 g.
Study of Prescription Screening for Administrative and Pharmaceutical Aspects at CS Farma Pharmacy in the Period June-December 2018 Afrisusnawati Rauf; Annisa Ika Muhrijannah; Hurria Hurria
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.14007

Abstract

Incomplete prescribing can be one of the causes of medication errors in patients. This incident can be avoided by screening prescriptions by pharmacists at pharmacies which include administrative and pharmaceutical studies. The purpose of this study was to determine the administrative and pharmaceutical prescription completeness in June-December 2018 at CS Farma Pharmacy. The research method was descriptive nonexperimental with retrospective data collection. Samples were collected by simple random sampling technique and obtained 385 pieces of recipes that have met the inclusion criteria. The result shows that the completeness of administrative prescriptions consisted of: patient name 99,22%, patient age 88,05%, sex 9,09%, body weight 0%, doctor's name 3,64%, doctor's SIP 0% , prescription date 97,92%, doctor's address 100%, doctor's telephone number 0,26% and doctor's initial 6,23%. Pharmaceutical aspects consisted of: dosage form 69,61%, dosage strength 57,66%, drug stability 100% and incompatibility 100%. It can be concluded that the prescription in CS Farma Pharmacy on June-December 2018 was not complete administratively and pharmaceutically yet, based on Permenkes No.73 In 2016.
Molecular Docking Study on COVID-19 Drug Activity of N-(2-phenylethyl)methanesulfonamide Derivatives as Main Protease Inhibitor Purwaniati - Purwaniati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.13945

Abstract

The aim of this research is to find potential new compounds that are potential to be developed as COVID-19 drugs with a mechanism to inhibit the main protease (Mpro) enzyme from the COVID-19 virus. The method used molecular docking with the AutodockTools 1.5.6 program and continued with the prediction of pharmacokinetic profiles and toxicity with the help of the PreADMET application. Inhibition potential was assessed based on the binding energy value and the inhibition constant. Research showes that natural ligand (N-(2-phenyl-ethyl) methanesulfonamide), S1, S3, S7, and S9 were compounds that provide inhibitory activity against Mpro enzymes which were more potent than lopinavir as a comparison. The binding energy and inhibition constants of natural ligands, S1, S3, S7, and S9 are lower than comparative compounds, respectively -1.61 kcal/mol and 66.26 mM. ADMET prediction shows that these potential compounds still need improvement in terms of pharmacokinetics and toxicity.
Quality and Release Profile of Captopril from Mucoadhesive Gastroretentive Tablet by Using Matrix Sodium Carboxymethyl Cellulose and Carbopol 934P Isriany Ismail; M. Asrah Hidayah Usman; Nur Ida
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.14028

Abstract

Captopril have good absorption in gastric pH and ionized on intestinal pH. It is necessary to keep the drug in the form of molecules in the area of the absoption. The mucoadhesive gastroretensive drug delivery system provides the possibility of controlled release in stomach in a certain amount of time. Research has been conducted to assess the quality and profile of captopril release in of a mucoadhesive gastroretensive tablet. Mucoadhesive tablets (MK) were made in 5 formulas by wet granulation method using carbopol 934P and sodium carboxymethyl cellulose as matrix with ratio 10: 0 (MK1), 0: 10 (MK2), 5: 5 (MK3), 7: 3 (MK4), and 3: 7 (MK5). The parameters which was evaluate were characteristics of granules and tablets and kinetics model of captopril release from tablets in 0,01 N HCl medium. Mucoadhesive tablets had different characteristics for each formula. Mucoadhesive tablets that had good quality and release profile were shown by MK4 and MK5 formula. They had controlled drug release profiles accorded to the Korsmeyer-Peppas and Higuchi kinetics models, respectively.
Activity of Bidens Pilosa Herb Infussion as Antiinflammatory Munifah Wahyuddin; Nurdaonah Nurdaonah; Ferawati Ferawati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.14004

Abstract

Ajeran (Bidens pilosa), traditionally, was widely used to reduce pain and inflammation. This study aims to determine the activity of Ajeran herb infusion as an anti-inflammatory. Determination of activity using 18 mice which were divided into 6 groups. Blank group (I) was given aquadest, groups II, III, IV and V were given Ajeran dry herb infusion with concentrations 10, 20, 30 and 40% w/v, respectively, and group VI was given sodium diclofenac suspension 0,195 mg/ml, each 1 ml. Inflammation induction was performed by administering eggwhite suspension 1% v/v on the sole of the left foot. Foot volume before and after induction were measured as normal and initial edema volume. After that, the mice were given treatment and measurements of foot volume again at 15, 30, 45 and 60 minutes. The test results showed that the infusion of Ajeran and diclofenac sodium could reduce edema starting at 15 minutes, which were 17.8% (II); 20.6% (III); 22.2% (IV); 25% (V); and 15% (VI). It was different with blank group, the volume of edema did not decrease (0%). At 60 minutes, the volume of edema in all groups higher decreased that at 15 minutes, namely 23.4% (I); 28.9 (II); 35.6 (III); 37% (IV); 41.7% (V); and 30% (VI). The conclusion is that the administration of Ajeran infusion can reduce the volume of edema of feet with inflammation of mice.
Comparison of Thiamine Contain in Mung Beans (Vigna radiata L.) and Soybean (Glycine max (L.) Mer.) with Fresh and Boiled Treatment Agus Suprijono; Yuni Utami
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.13896

Abstract

Mung beans (Vigna radiata L.) and soybeans (Glycine max (L.) Mer.) are species of nuts that contain good nutrients for health, such as thiamine or vitamin B1. Thiamine can increase appetite and important in nervous system. Both species of beans can be processed into consumable sprouts, both fresh and boiled. The research aims to compare the concentrations of thiamine in mung beans sprouts and soybeans sprouts in fresh and boiled conditions. The research procedure began with prepared fresh and boiled samples. Boiled samples were prepared by boiled sprouts for 3 minutes at 100°C. Thiamine was extracted from samples used 0,1 N HCl by heated on a water bath at 100°C for 30 minutes. The extracts of fresh and boiled sprouts were analyzed qualitatively used chemical reagents and quantitatively used spectrophotometer UV-Vis. Qualitative analysis showed that both fresh and boiled mung beans sprouts and soybeans sprouts contain thiamine. Quantitative test results for boiled and fresh mung beans sprouts were 0,26% and 0,15%, while soybeans were 0,64% and 0,44%, respectively. The thiamine content in soybeans sprouts is higher than in mung beans sprouts. Decrease of thiamine concentration in mung beans sprouts was higher at 42,31%, for boiled sample than soybeansbenas sprouts at 31,25%. The results of statistical tests used the t test showed a significant difference in thiamine concentration between fresh and boiled beans, both mung beans and soybeans.
Efficacy of Petai (Parkia speciosa, HASSK) leaf extract as an antidyslipidemic herb in Rattus norvegicus induced by high-fat feed Jatmiko Susilo; Anita Widya Astuti; Dewi Larasati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.13761

Abstract

This study aims to analyze the effect of Petai (Parkia speciosa, HASSK) leaf extract on total cholesterol, triglycerides, LDL and HDL levels in dyslipidemic rat models induced high-fat feed. The pre and post-test with control group design using 30 rats were divided into 5 groups, namely positive, normal, and Petai leaf extract at doses of 100, 200 and 400 mg/kg BW. All rats were fed high fat diet for 14 days. The extract group was given Petai leaf extract orally from day 14 to day 28. Lipid profiles were tested using enzymatic spectrophotometry method. Petai leaf extract was identified to contain flavonoid compounds. The research showed that the Petai leaf extract at a dose of 100, 200 and 400 mg / kg BW  were able to decrease total cholesterol: (-32.06 ± 3.63), (-47.23 ± 2.98), and (-49,18 ± 2.66), mg / dL; triglyceride: (-11.12 ± 3.99), (-37.31 ± 0.65), and (-43.01 ± 1.17) mg / dL; LDL: (-17.14 ± 9.30), (-46.51 ± 1.99), and (-46.51 ± 1.99) mg / dL; and increasing HDL levels: (6.44 ± 0.21), (8.42 ± 0.73), and (12.1 ± 0.43) mg / dL respectively. This study proves that Petai leaf extract has anti-dyslipidemic activity in rat models by reducing total cholesterol, triglycerides, and LDL and increasing HDL levels.
Kemuning Leaves Extract Gel (Murraya panicula L.): A Study of Quality and Efficacy in Healing Burns Khairunnisa Hasbullah; Faridha Yenny Nonci; Muh. Ikhlas Arsul
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.13984

Abstract

This study aims to determine the activity of kemuning leaves extract in healing burns, and efficacy and quality of the extract in gel dosage form. The research was started with kemuning leaves extraction used maceration method with ethanol 96%, ethyl acetate and n-hexane as solvent. Each extract was activity tested for healing burn in rabbits. The extract that is most effective in wound healing then formulated into gel. The gel preparations were made in 3 variations of concentration, namely 5% (FI), 10% (FII), and 15% (FIII), with basis by carbopol 940 gel, triethanolamine, and methyl paraben. Then, gels were tested for efficacy and quality. The efficacy test follows the activity test procedure. Gel quality test includes organoleptic, pH, viscosity, dispersibility, and homogenity. The activity test showed that ethanol 96% extract, ethyl acetate and n-hexane healed burns in 13,3; 14,3; and 15,3 days, respectively. While the results of the gel efficacy test for FI, FII and FIII were 13,6; 11,6; and 9,6 days, respectively. In general, all gels have good qualities in every parameter, except the viscosity of FII and FIII which is slightly higher. Based on the results of the research, ethanol 96% extract was the most effective in healing burn. In addition, FIII gel has the best efficacy with good qualities except viscosity.

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