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"Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No"
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<![CDATA[Efektivitas Penggunaan Nanopartikel Karbon Sebagai Pewarna Nodus Limfa Dalam Limfadenektomi Pada Kanker Kolorektal: Sebuah Kajian Sistematik ]]>
<![CDATA[Jessica Audrey]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v9i2.277
<![CDATA[Background: Colorectal cancer (CRC) is the third most common malignancy in the world, claiming at least 881,000 lives in a year. Despite numerous treatment options developed in recent years, surgical resection remains the treatment of choice. Considering possible metastasis to nearby lymph nodes, sufficient lymphadenectomy is an important prognostic factor and critical for accurate staging. However, number of lymph nodes harvested is often inadequate. Carbon nanoparticles has recently emerged as an excellent method of lymph node tracer in CRC. Yet, reviews regarding its effectiveness is still lacking.Aim: To evaluate the effectiveness of carbon nanoparticles in detecting lymph nodes and improving staging accuracy for colorectal cancer.Method: A systematic review was conducted through PubMed, Scopus, EBSCOhost, and Cochrane, searching for studies implementing carbon nanoparticles in detecting lymph nodes during surgical resection of CRC. Quality assessments of studies selected were performed with selected risk-of-bias assessment tools.Outcome: The search yielded 10 studies with a total of 1387 subjects. Carbon nanoparticles were effective in increasing the total number of harvested lymph nodes and improving the ability of detecting smaller lymph nodes of <5 mm. Number of positive lymph nodes did not differ significantly with controls; however, carbon nanoparticles effectively improved staging accuracy, thereby signifying a reduction in risk of understaging. Moreover, operative time and blood loss were reduced in comparison to conventional methods. No significant adverse effects were reported.Conclusion: To conclude, carbon nanoparticles showed promising potentials as lymph node tracer to help improve harvest and staging accuracy in CRC patients.]]>
<![CDATA[Perang Melawan Bahaya Hoaks COVID-19 di Dunia ]]>
<![CDATA[Ridwan Balatif]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v9i2.330
<![CDATA[The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the cause of the Coronavirus Disease 2019 (COVID-19) pandemic. As of February 28, 2021, around 113 million people have confirmed COVID-19 globally. One of the things that hampers the handling of COVID-19 both globally and in Indonesia is the result of the large number of hoaxes circulating about COVID-19. The purpose of this article is written to increase understanding of the circulating COVID-19 hoaxes and the spirit of education against hoaxes related to COVID-19. About 89% of hoaxes circulating on various social media are rumors, 7.8% are in the form of conspiracy theories and the rest are in the form of stigma. This circulating hoax can harm others, such as information that alcohol can kill the corona virus in the body. As a result of this information, 44 Iranians have died from alcohol poisoning which is believed to kill the corona virus. In addition, the existence of hoaxes such as "COVID-19 does not exist" can result in the public ignoring health protocols which have an impact on the handling of COVID-19. Hoaxes circulating on various social media platforms have had a big impact in handling the COVID-19 pandemic. It is hoped that there will be good cooperation between the government and the community so that the COVID-19 pandemic can be resolved immediately]]>
<![CDATA[FAKTOR RISIKO APNEA TIDUR OBSTRUKTIF YANG DAPAT DIMODIFIKASI ]]>
<![CDATA[Kemal Akbar Suryoadji]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v9i2.337
<![CDATA[Background: Obstructive sleep apnea, also known as OSA (obstructive sleep apnea), is a sleep disorder in the form of a recurring complete or partial collapse of the airway. The prevalence of obstructive sleep apnea in America is 14% in men and 5% in women. The population in Asia is also a risk factor for obstructive sleep apnea. Methods: The literacy scan used 14 most recent and reliable international journals to describe modifiable risk factors for obstructive sleep apnea. Discussion: Obstructive sleep apnea is associated with other diseases such as cardiovascular, metabolic, and neuropsychiatric disorders. There are three important aspects that are modifiable risk factors for obstructive sleep apnea, including ideal body weight, namely to maintain a body mass index of less than 25 kg / m2, optimal physical activity by doing aerobic physical exercise for 150 minutes per week. , and reduce consumption of cigarettes and alcohol. Conclusion: Modifiable risk factors for obstructive sleep apnea include ideal body weight, physical activity, and consumption of cigarettes and alcohol. These factors can be used as a solution and prevention in obstructive sleep apnea to also avoid symptoms and other related diseases.]]>
<![CDATA[VAKSIN DNA HEAT SHOCK PROTEIN 65 (HSP65) DENGAN KLK YANG TERENKAPSULASI NANOPARTIKEL PLGA SEBAGAI INOVASI TERAPI PREVENTIF DAN KURATIF TUBERKULOSIS ]]>
<![CDATA[Jaya Firmansyah]]>;
<![CDATA[Hana Nafisah]]>;
<![CDATA[Nabila Rayhan Yasmin]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v9i2.364
<![CDATA[Background: Tuberculosis has high mortality rate. BCG vaccine is used for preventing tuberculosis infection. However, the protective effect of the BCG vaccine varies from 0-80% and decreases significantly after 10-15 years. So, new vaccine innovations that are more protective are needed. The purpose is to determine the effectiveness of using the hsp65 DNA vaccine with KLK adjuvant encapsulated PLGA nanoparticles as a preventive and curative therapeutic innovation for tuberculosis. Methods: Reviewed papers were obtained using search engines such as Google Scholar, Proquest, Sciencedirect, and PubMed with publication range from 2010 to 2020 and paper were selected theirs validity and reliability. Then literature review and article writing are conducted. Discussion: The hsp65 DNA vaccine can trigger cytokine production, such as IFN-γ, IL-2, higher CD4 +, CD8 +, T cell activity than the BCG vaccine. There was significant decrease in the level of MTB in mice injected with the hsp65 vaccine. The combination of the Hsp65 + KLK vaccine showed the least lung damage and area of inflammation and the highest Th1 response and IL-10 production among the other vaccines. To increase the efficiency of the DNA hsp65 + KLK vaccine, a dose reduction was made to a single dose using biodegradable PLGA nanoparticles as an antigen-carrying system. Conclusion: The combination of DNA hsp65 and KLK vaccines can trigger specific immune responses against MTB and with PLGA encapsulation can increase its efficiency, so it has high potential as a preventive and curative therapy for tuberculosis.]]>
<![CDATA[PENGARUH KAFEIN TERHADAP BERBAGAI PARAMETER AKTIVITAS FISIK DAN METABOLIK PADA POPULASI SEDENTER SEBAGAI UPAYA MENURUNKAN RISIKO PENYAKIT KARDIOVASKULAR: SEBUAH KAJIAN SISTEMATIS ]]>
<![CDATA[Valerie Josephine Dirjayanto]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v9i2.409
<![CDATA[Background: Current circumstances regarding the development of cardiovascular disease in Indonesia is causing remarkable concerns as its metabolic risk factors become more uncontrollable. As a way to prevent cardiovascular disease, physical activity must be done adequately and efficiently, especially in sedentary individuals, to improve metabolic profile. This review is aimed to assess the effect of caffeine to various physical activity and metabolic parameters in sedentary individuals. Methods: A systematic review was conducted through PubMed, Cochrane, EBSCOhost, and Scopus, in search for clinical trials implementing caffeine together with physical activity in sedentary individuals and its efficacy in prevention, thus correlating it with cardiovascular risk factors. Quality assessments of studies selected were performed with Revised Cochrane risk of bias tool for randomized trials (RoB 2.0). Discussion: The search yielded 5 clinical trials with a total of 90 subjects. Caffeine in addition to physical activity is proven effective in controlling various metabolic parameters in sedentary subjects. The intervention elicits more efficient weight loss, induces more energy consumption, improvement in VO2max, and increases oxygen consumption. Caffeine also improves lipid profile as well as blood pressure. No significant adverse effects are reported. Conclusion: Caffeine showed promising potentials in increasing the effectiveness of physical activity in controlling metabolic profile and eventually lower the risk for cardiovascular diseases in sedentary individuals. Further studies with larger samples are required in order to substantiate the evidence.]]>
<![CDATA[CLINICAL OUTCOMES OF IVERMECTIN IN COVID-19 TREATMENT: AN EVIDENCE-BASED CASE REPORT FROM SYSTEMATIC REVIEWS AND META-ANALYSES ]]>
<![CDATA[Jason Theola]]>;
<![CDATA[Muhammad Ikrar Hermanadi]]>;
<![CDATA[Kahlil Gibran]]>;
<![CDATA[Syarifaha Ihsan]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v9i2.411
<![CDATA[Background: Ivermectin has demonstrated beneficial results on clinical outcomes in COVID-19 patients. Several countries have included ivermectin in their guidelines, though WHO recommended against its usage. Therefore, this study was aimed to establish the clinical outcomes of ivermectin in COVID-19 patients by an evidence-based method. Method: Article searching was completed in PubMed, Cochrane, and Scopus from July 9 - 10 2021. The results were limited to only systematic reviews and meta-analyses. Hand searching was conducted to obtain relevant studies from external resources. The results were evaluated using inclusion and exclusion criteria. The full texts were obtained and critically reviewed using Oxford Centre for Evidence-Based Medicine critical appraisal tools. Result: Three systematic reviews and meta-analyses were selected and critically reviewed. All three studies were considered valid, important, and applicable. However, the quality of these studies varied from low to high. Conclusion: Overall studies showed that ivermectin has the potential to improve clinical outcomes in COVID-19 patients.]]>
<![CDATA[KARAKTERISTIK MORFOLOGI ARCUS PALATOGLOSSUS DAN ARCUS PALATOPHARYNGEUS TERHADAP SKOR KUESIONER BERLIN PADA MAHASISWA FK USU ANGKATAN 2016 ]]>
<![CDATA[Vani Wulan Dari]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v9i2.424
<![CDATA[Obstructive sleep apnea (OSA) is a major public health problem, with a high prevalence. The Berlin Questionnaire is a questionnaire aimed at OSA screening. Palus palatoglossus and arcus palatopharyngeus are located in the oropharynx which is the most frequent place of OSA. The purpose of this study was to determine the morphological characteristics of the palatoglossus arcus and palatopharyngeus arcus on the Berlin questionnaire on 2016 USU FK students to facilitate OSA screening. This study used a descriptive approach with cross sectional design, while the sampling used primary data, namely in USU FK 2016 students. The palatoglossus arcus and arcatopharyngeus arcus high-risk group classification OSA arcus 1/2 classification (8.8%) . As many as 19.1% of 2016 USU FK students experienced a high risk of OSA. The arcus classification group of 10 respondents at high risk of OSA is arcus 1/2 classification (8.8%). The BMI group of respondents who were at high risk of OSA was obese 1 (8.8%). The neck circumference group of respondents at high risk of OSA is the large neck circumference (14.7%). Based on the nasal congestion group respondents who are at high risk of OSA that is with nasal congestion (17.6%). The palate classification group of respondents at high risk of OSA is the low palate classification (10.3%). From the results of this study it was concluded that respondents with arcus 1/2 classification were the most respondents and also a high risk of OSA.]]>
<![CDATA[HUBUNGAN ANTARA BERAT LAHIR DENGAN REFLUKS GASTROESOFAGUS PADA BAYI USIA 0–1 TAHUN ]]>
<![CDATA[Hamzah Haryo Prakoso]]>;
<![CDATA[Evi Rokhayati]]>;
<![CDATA[Dwi Hidayah,]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v9i1.426
<![CDATA[Background: Low birth weight babies are population at risk for gastroesophageal reflux and its complications due to physiologic immaturity of digestive system. However, the pathomechanism remains unclear. There is no similar study conducted in Surakarta City and still lack of studies on 0-1 year infants. The aim of this study is to evaluate Gastroesophageal reflux risk in low birth weight infants age 0–1 year. Method: Case control study on infants aged 0–1 year in Ngoresan Public Health Center, Surakarta. Samples were obtained by purposive sampling method in April–May 2021 with a questionnaire on infant characteristics and the Infant-Gastroesophageal Reflux Questionnaire as research instruments. Results: There were 60 samples divided into case and control groups with a 1:1 ratio. There was no significant relationship between birth weight and gastroesophageal reflux (p = 0.612). Discussion: Research conducted in Semarang and Italy declared no correlation between birth weight and gastroesophageal reflux. The relationship is more visible if infants have a birth weight <1,500 grams and a history of the disease such as bronchopulmonary dysplasia or chronic lung disease. Conclusion: There is no relationship between birth weight and gastroesophageal reflux in infants aged 0–1 years]]>
<![CDATA[POTENSI KOMBINASI NANOPARTIKEL FULLERENOL DAN INHIBITOR UREASE DALAM TATALAKSANA FARMAKOLOGIS INFEKSI HELICOBACTER PYLORI ]]>
<![CDATA[Nathaniel Gilbert Dyson]]>;
<![CDATA[Aldithya Fakhri]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v9i2.441
<![CDATA[Background: Over 50% of global population have been infected by Helicobacter pylori. However, current pharmacological management of Helicobacter pylori infection still possess many challenges, especially antibiotic resistance and side effects of PPI drugs usage. Recent studies have found that fullerenol nanoparticles and urease inhibitors are potential to eradicate Helicobacter pylori infection. Methods: Literature search is done from three international databases, namely PubMed, Scopus, and Google Scholar, independently with previously stated inclusion and exclusion criteria. The final search results in 5 eligible studies which will further be discussed. Discussion: Fullerenol nanoparticles can undergo a pinacol rearrangement and have carboxyl or carbonyl functional group that can act similarly like peroxidase enzyme activity to destroy polysaccharides in the cell wall of Helicobacter pylori. Biotoxicity of the fullerenol nanoparticles in the toxicity test with the Drosophila melanogaster showed no significant side effects. On the other hand, urease inhibitors such as catechol and p-benzonequinol, can decrease ammonia synthesis and lower the pH in the gastric lumen. This condition inhibit growth of Helicobacter pylori and increase the work of fullerenol nanoparticles. Biotoxicity of urease inhibitors are also very low, proved by the morphological changes of human glioblastoma cells (GL-15) in vitro at concentrations above 200 M. Conclusion: Fullerenol nanoparticles act similarly like proxidase enzyme to destroy the cell wall of Helicobacter pylori. On the other hand, urease inhibitors decrease ammonia synthesis and lower gastric lumen pH to prevent infection. Combination of fullerenol nanoparticles and urease enzyme inhibitors are highly potential as pharmacological treatment of Helicobacter pylori.]]>
<![CDATA[CARDIAC STEM CELL DENGAN INDUKSI TNFR1-BLOCKER DAN NRG-1/ERB-B4 SEBAGAI TERAPI PEREMAJAAN GAGAL JANTUNG AKIBAT PENYAKIT JANTUNG ISKEMIK ]]>
<![CDATA[Aiman Hilmi Asaduddin]]>;
<![CDATA[Annisa Syarifa Istighfarini]]>;
<![CDATA[Alya Sabilah Siregar]]>;
<![CDATA[‘Aininna ‘Izzah Zafira]]>;
<![CDATA[Farah Nur Adiba]]>
<![CDATA[ JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No ]]>
Publisher : <![CDATA[BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia) ]]>
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DOI: 10.53366/jimki.v9i2.442
<![CDATA[Heart Failure (HF) is a complex clinical syndrome because of cardiac abnormalities. The incidence of heart failure could reach 37.7 million in 2010. Meta-analysis research showed that stem cell can improve cardiac function. Cardiac stem cell (CSC) therapy on HF can be optimized using Tumor Necrosis Factor-α receptor type-1 (TNFR1)-Blocker and Neuregulin-1 (NRG-1)/ Erythroblastic leukemia viral oncogene homolog 4 (Erb-B4)induction. Thus, the aims of this literature review are to determine CSC potency on HF and TNFR1-Blocker and NRG-1/Erb-B4 effects on CSC therapy optimization. The method used was using medical subject headings, namely CSC, TNFR1-Blocker, NRG-1/Erb-B4, and heart failure. The inclusion and exclusion criteria have been used to eliminate inappropriate journals so there were 40 journals used for this article. The results showed that CSC could differentiate into three major cardiac lineage, cardiomyocyte, endothelial cell, and smooth muscle cell. Those components are essential for cardiac rejuvenation therapy. Besides, TNF-α have a role for contractile dysfunction and induce hypertrophy and apoptosis of cardiac myocyte. Expression level of TNFR1 was significantly increased in ischemic HF. Interaction between TNF-α and TNFR1 led to apoptosis via Receptor Interacting Protein 1 (RIP1) and inhibited CSC proliferation. Thus, TNFR1 blockade will potentially leads to apoptosis prevention and induce proliferation. In the other hand, NRG-1 proved to plays some cellular mechanism via Erb-B4. NRG-1/Erb-B4 also could increase cell mobility and inhibit apoptosis via activation of PI3K/Akt. In conclusion, signaling induction of TNFR1-blocker and NRG1/Erb-B4 have potential role to optimized CSC therapy on ischemic HF rejuvenation.]]>
