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Anna Safitri
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Research Center for Smart Molecule of Natural Genetics Resources (SMONAGENES) office: 2nd floor MIPA Building, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Jl. Veteran Malang, East Java, Indonesia – 65145
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JSMARTech : Journal of Smart Bioprospecting and Technology
Published by Universitas Brawijaya
ISSN : 26860805     EISSN : 27147894     DOI : https://doi.org/10.21776/ub.jsmartech.2020.001.02.
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
JSMARTech : Journal of Smart Bioprospecting and Technology (p-ISSN: 2686-0805, e-ISSN : 2714-7894) is an Open Access Scientific Journal published by Research Center of Smart Molecule and Natural Genetics Resources (SMONAGENES), Universitas Brawijaya, Malang, East Java, Indonesia, since 2019. It is a journal covering of bioprospecting, biochemical, biotechnology, bioinformatics, natural product, pharmaceuticals, biomedical, genetics engineering, nutrigenomic, and nanotechnology. The journal publishes a manuscript written in English for original research papers, short communications, and review articles. The paper published in this journal implies that the work described has not been, and will not be published elsewhere, except in abstract, as part of a lecture, review or academic thesis.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 6 Documents
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Search results for , issue "Vol. 4 No. 1 (2023): JSMARTech Volume 4, No. 1, 2023" : 6 Documents clear
Retinal Ganglion Cell Death of Guinea Pig is Slower Than Rat as Optic Nerve Transection Animal Model Tomohiko Sasase; Fatchiyah Fatchiyah; Takeshi Ohta
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 4 No. 1 (2023): JSMARTech Volume 4, No. 1, 2023
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2023.004.01.04

Abstract

Glaucoma is a progressive optic neuropathy that leads to retinal ganglion cell (RGC) apoptosis and is a leading cause of acquired blindness. Recently, lack of clinical protective treatment for  optic nerve in glaucoma thus inhibitor drugs towards progression of RGC degeneration are urgently needed. In this study, we established a guinea pig optic nerve transection model and investigated the conditions under which RGC death is evaluated in the development of retinal neuroprotective drugs for the treatment of glaucoma. Guinea pig optic nerve axotomy induces RGC death similarly to other rodent models; however, the time to progress to significant RGC death is 21 days after transection and is longer than in the rat, 10 days after optic nerve axotomy. The results are useful for evaluating species-specific optic neuroprotective agents against rats and mice.
Antioxidant Assay of Endophytic Fungi Extract from Mango Mistletoe (Dendrophthoe pentandra (L.) Miq) Leaves Dewi Qurrot 'Aini; Nour Athiroh Abdoes Sjakoer; Nurul Jadid Mubarakati
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 4 No. 1 (2023): JSMARTech Volume 4, No. 1, 2023
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2023.004.01.09

Abstract

Endophytic fungi found in mango mistletoe (Dendrophthoe pentandra (L.) Miq) leaves may potentially create a variety of bioactive antioxidant compounds, and their prospects for large-scale production especially for phytopharmaceuticals products without excessive natural exploitation. The objective of this study was to investigate the antioxidant properties of endophytic fungal extracts obtained from mango mistletoe leaves. The method used is experimental laboratory research with a quantitative approach through the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging activity method. The test sample concentrations ranged from 120 µg/ml to 200 µg/ml. The results of this study indicated that isolates of EFMM 1 (Aspergillus spp.) has an IC50 of -12,27 µg/ml, EFMM 2 (Neurospora spp.) has an IC50 of 10,40 µg/ml, EFMM 3 (Hormiscium spp.) has an IC50 of 49,44 µg/ml, and EFMM 4 (Exserohillum spp.) has an IC50 of 299,32 µg/ml. The conclusion is that EFMM 1 doesn’t have an antioxidant activity, while EFMM 2 has the highest antioxidant potential comparable to ascorbic acid.
Secondary Metabolite Composition and Bioactivity of Genus Albizia: A Review Momodou Salieu Sowe; Anayo Christian Etonihu
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 4 No. 1 (2023): JSMARTech Volume 4, No. 1, 2023
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2023.004.01.14

Abstract

Traditional medicine is being revalued all around the world because of considerable research on various plant species and their therapeutic properties. Traditional medicinal beliefs and practices are deeply rooted in The Gambia, and forest resources are a source of plants for medicine. A study has estimated the presence of one hundred and fifty (150) plant species in The Gambia, distributed between 28 different plant families. Among the plant species, Albizia seems to possess numerous pharmacological properties. Albizia plants are high in secondary metabolites, according to phytochemical investigations, and pharmacological tests of plant extracts have demonstrated antibacterial, anti-inflammatory, and analgesic effects. Albizia plant components are used in traditional medicine to cure a variety of diseases like lung infections, asthma, pile, diarrhea, gonorrhea, ulcers, hemorrhoids, anxiety, depression, and insomnia. Different solvent extracts of the genus Albizia have demonstrated excellent efficacy against S. Typhimurium, S. Enteritidis, S. Dublin, S. aureus, E. coli, V. parahaemolyticus, B. cereus, S. aureus, and S. pyogenes. The radical scavenging activity of the genus Albizia exhibits a significant antioxidant activity with relatively high EC50 and IC50 values.
Phylogenetic construction of Green Algae Based on the rbcL Gene Aliarani Rosyidiana Putri; Galuh Arkana; Haikal Ageng Maulana; Septhyanti Aprilia Kavitarna; Rayhan Yugo Nurul Maulana; Muhammad Wisam Wira Sakti; Turhadi Turhadi; Fatchiyah Fatchiyah
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 4 No. 1 (2023): JSMARTech Volume 4, No. 1, 2023
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2023.004.01.25

Abstract

Chlorophyta (green algae) is one of the algae that can be found in (both oceans and freshwater lakes) as well as land with temperate to dry climates. Chlorophyta or green algae can be found in oceans, freshwater lakes, temperate land, and dry climate land.  In addition, chlorophyta can also be found in semi-aquatic environments, such as rocks, moist soil, and moist tree bark. This study aims to analyze the phylogenetic relationship among chlorophyta species based on rbcL gene to classify the diversity of green algae in Indonesia. The green algae gene rbcL sequence with 20 species was obtained from NCBI. The sequences obtained were aligned with ClustalW and the mutation patterns were analyzed. The aligned sequences were made phylogenetic trees by MEGA-X with the Maximum Parsimony method and 1000 bootstrap. The total percentage of transversions that occurred was 10.75%, while the percentage of transitions was 7.85%. The construction of the phylogenetic tree shows that the chlorophyta species are grouped based on their habitat in the same clade. Clad 1 consists of genera Chlorella, Coccomyxa, and Volvox with freshwater habitats and a genus of Parachlorella with soil habitat. Clade 2 consists of genera Chlorococcum, Tetradesmus, Crucigenia, and Desmodesmus with freshwater habitats and a genus of Chlorococcum with soil habitats. Clad 3 consists of genera Ulva and Chlorella salina with marine habitat. The furthest pairwise distance analysis results were shown by Coccomyxa subellipsoidea and Sargassum schnetteri with a value of 1.18902. The kinship of the species of the Chlorophyta division based on the rbcL gene is divided into 3 clade separated by habitat. The phylogenetic tree in the Chlorophyta division shows that the rbcL gene is sensitive enough to separate among genera and can be utilized in phylogenetic studies.
Inhibition of Antibacterial Bioactive Compounds from Awar-Awar (Ficus septica Burm, F.) Leaves for Methicillin Resistant Staphylococcus aureus (MRSA) Infection: an In Silico Study Friska Amanda Nurlailiyah; Ni Putu Alira Kinanti Febrina Putri; Siti Saidah Qurrotul A’yun; Sofia Nur Cahyani; Aneila Maritza Larasati; Victor Alvianoes Guterez Hose; Fatchiyah Fatchiyah
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 4 No. 1 (2023): JSMARTech Volume 4, No. 1, 2023
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2023.004.01.32

Abstract

Methicillin resistant Staphylococcus aureus (MRSA) is a type of Staphylococcus aureus infection that can increase the patients’ number with prevalence variation in each country. Methicillin resistant Staphylococcus aureus (MRSA) can be treated by inhibiting the activity of the BlaR1 transducer protein as an MRSA sensor against transmembrane antibiotics using bioactive compounds. Ficus septica is a local variety that has potential as an antibacterial. In silico study of the bioactive compounds found in Ficus septica can inhibit the synthesis of Staphylococcus aureus cell wall based on molecular docking tests with the control compound is Linezolid as antibiotics. In addition, ADME prediction, binding affinity, and binding site analysis were also performed. The results showed that there were 9 active compounds from Ficus septica leaves which had antibacterial potential and fulfilled Lipinski's rules criteria. Analysis of the binding site indicated that Coumarin compound could bind to the most BlaR1 protein active sites than other bioactive compounds in Ficus septica, including on the Lys526 and Thr527 active sites. Based on interaction analysis, it can be concluded that the Coumarin compounds of Ficus septica leaves can provide a therapeutic effect that can fight MRSA infection which can be proven by in vitro tests.
Front Matter JSMartech Vol.04., No.01 Fatchiyah Fatchiyah
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 4 No. 1 (2023): JSMARTech Volume 4, No. 1, 2023
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2023.004.01.01

Abstract

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