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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) Biotropika Berdikari: Jurnal Pengabdian Masyarakat Indonesia JSMARTech : Journal of Smart Bioprospecting and Technology Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat)
Fatchiyah Fatchiyah
Department Of Biology, Faculty Of Mathematics And Natural Sciences, Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Business model analysis and determination of production cost of Micro, Small and Medium Enterprises (MSME) Product Businesses Talok Village, Turen Distric, Malang with Business Model Canvas (BMC) Fatchiyah Fatchiyah; Nia Kurniawan; Ary Mustofa Ahmad; Irfan Mustafa; Lidwina Faraline Triprisila; Rista Nikmatu Rohmah; Anna Safitri; Nia Kurnianingsih; Tri Wahyu Nugroho
Berdikari: Jurnal Pengabdian Masyarakat Indonesia Vol. 1 No. 2 (2018): Berdikari: Jurnal Pengabdian Masyarakat Indonesia
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.961 KB)

Abstract

Talok is a partner district with economic conditions that have developing status according District Development Index values. The developing status related with susceptible of economic shocks, natural disasters and social conflicts will be effect to underdeveloped district. This Community Empowerment Program is purpose to develop Micro, Small and Medium Enterprises (MSME) product businesses can expect to income increasing of enterprise through the Business Model Canvas (BMC) approach. Mapping survey of local potentials from partner district was observed to achieve the success of community service activity. In this survey, we collaborate with MSME partners are (1) Samiler Crackers MSME group, (2) Cassava Chips MSME group, (3) Lempeng Crackers MSME group. The data was analyses using descriptive and qualitative method by using the in-depth interview in collecting primary data needed during the research process. The BMC analysis on each element of business model canvas could improve the service quality, marketing activity, infrastructure and financial ability. Business model canvas focuses on business ideas to create value in the business. In addition, the cost of production calculation is very important for selling price determination of the product to avoid the losses condition.
Identification of Fingerprints Pattern in Mixed Family of Chinese-Javanese Ethnic Istiftakhun Nikmah; Fatchiyah Fatchiyah
Journal of Tropical Life Science Vol. 7 No. 3 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.03.12

Abstract

The aim of this study is to identify fingerprints patterns from the mixed family of Chinese-Javanese ethnic. The fingerprint patterns divided into three main patterns, i.e. arch, loop and whorl. The respondents were determined based on inclusion criteria (subject of research qualified as a sample) and the exclusion criteria (subjects which could not be used as a sample) through interviews and questionnaires. First, respondent’s fingers cleaned with alcohol or washed using soapy water. The patterns of fingerprint were taken by pressing one by one using an inked stamp pad. Then, printed on white paper which has been given a code and serial number of fingers for each respondent. The last step was to identify the specific characteristic of fingerprint patterns from the respondents and analyzed it while determining about similarity and variability of inter-generations. The results indicated that the mixed family of Chinese-Javanese ethnic had whorl variant pattern (plain whorl and double loop whorl) on the thumbs as a specific marker of Javanese ethnic. Otherwise, radial loop on the index and tented arch pattern on both index and little finger are the unique marker of Chinese ethnic. Thus, both Javanese and Chinese ethnic have co-dominant fingerprint patterns for mixed family of Chinese-Javanese ethnic.
Level of mRNA Insulin Gene and Blood Glucose STZ-Induced Diabetic Rat are Improved by Glucomannan of Amorphophallus muelleri Blume from East Java Forest Indonesia Fatchiyah Fatchiyah; Damai Aulia Nurmasari; Nuri Masruro; Rista Nikmatu Rohmah; Lidwina Faraline Triprisila; Mulyati Mulyati; Takahisa Yamada; Takashi Ohta
Journal of Tropical Life Science Vol. 9 No. 2 (2019)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.09.02.05

Abstract

Diabetes mellitus is one of metabolic disorder with high level of blood sugar glucose and reduces pancreatic-insulin levels that are altered by unhealthy food and lifestyle. To manage the blood glucose and insulin level, we need the diabetes dietary management related with insulin gene cascade. The purpose of this study was to investigate the influence glucomannan fiber to mRNA level of the insulin gene and genes cascade expression of target cells of type 1 diabetic rat. Three-month-old male (Rattus norvegicus strain Wistar) were fed with fiber of glucomannan of Amorphophallus muelleri Blume with dosage 0,06g/kg BW and 0.12g/kg BW every day during one month. RNA dot blotting with specific cDNA probe was performed mRNA level of insulin gene. The result of this study showed that glucomannan could reduce of body weight and blood glucose level significantly. The mRNA level of insulin gene of diabetic rats-treated 0.12g/kg BW glucomannan fiber dosage was the highest significance level among of all groups. In histopathological analysis, glucomannan was increasing significantly in IRS-1 level expression proliferate properly and consistently increasing of the PI3-K expression level in treated diabetic rats. This study indicates that the 0.12g/kg BW glucomannan was optimum dosage that effectively as role for alternative high-fiber therapy of type 1 diabetic through insulin receptor tyrosine kinase pathway. 
Restraint Stress Impacts on Behavioral Changes and Adrenal and Kidney Tissue Histopathology of Adult Mice Davy Reyhanditya; Viona Faiqoh Hikmawati; Nia Kurnianingsih; Fatchiyah Fatchiyah
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.1

Abstract

Restraint stress causes changes in the brain parameters. Little research has been done on the impact of restraint stress on other tissues, including adrenal glands and kidneys. This study aimed to determine the effect of restraint stress on eating behaviors, depressive-like, anxiety-like behaviors, weight gain as well as histopathological changes in the kidneys and adrenal glands. Twenty adult BALB/c mice were assigned into control male, stressed male, control female, and stressed female. Restraint stress was applied two hours/day for 14 days. Tail suspension and open field tests were carried out to perform behavior analyses. Adrenal and kidney histological slides were observed under an Olympus CX-31 microscope and visualized using an Olympus E330 camera. The two-way ANOVA test was used for statistical analysis using GraphPad Prism 9.0.0 software. We found that restraint stress defeat appetite and reduces weight gain particularly in stressed female. However, depressive- and anxiety-like behavior were demonstrated in both sexes. Adrenal and kidney tissues of stressed mice demonstrated a higher number of necrotic cells than control. The pyknosis phase was more common than the karyorrhexis and karyolitic phases. Interestingly, male mice were more receptive to stress than female mice. These findings indicate that restraint stress leads to behavioral changes and cellular defects in the adrenal glands and kidneys, particularly in male mice. The sympathetic activation and hypothalamus-pituitary-axis stimulation are assumed as the underlying stress effect of the restraint procedure. The restraint stress method has the potential to be used in future research on stress-responsive target organs.
Pemberdayaan Kelompok Ibu PKK Desa dalam Penyuluhan Menu Nutrisi Sehat Berbasis Produk Lokal di Desa Karangwidoro, Kecamatan Dau, Kabupaten Malang Fatchiyah Fatchiyah; Eko Suyanto; Ernanin Dyah Wijayanti; Yeni Avidhatul Husnah
TRI DHARMA MANDIRI: Diseminasi dan Hilirisasi Riset kepada Masyarakat (Jurnal Pengabdian kepada Masyarakat) Vol 2, No 2 (2022)
Publisher : JTRIDHARMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtridharma.2022.002.02.70

Abstract

Berdasarkan hasil penelitian riset kesehatan dasar, konsumsi pangan masyarakat Indonesia saat ini sebagian besar belum sesuai nutrisi sehat dan seimbang khususnya konsumsi sayuran dan buah-buahan. Hal ini menimbulkan kurangnya implementasi konsumsi pangan sehat masyarakat desa. Penyuluhan dan edukasi menu nutrisi sehat berbasis produk lokal menjadi penting dilakukan untuk mendukung Gerakan Masyarakat Hidup Sehat (GERMAS) serta pemanfaatan pangan lokal yang bernutrisi sehat. Salah satu desa dengan potensi sumber daya lokal yang melimpah sebagai produk lokal pangan nutrisi sehat adalah Desa Karangwidoro, Kecamatan Dau, Kabupaten Malang. Kegiatan penyuluhan ini merupakan upaya pemenuhan program pengabdian kepada masyarakat DPP/SPP Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Brawijaya Tahun 2022 untuk memberikan edukasi bagi masyarakat khususnya ibu-ibu PKK sebagai penggerak pertama dalam keluarga. Metode pelaksanaan dilakukan dengan 5 tahap yaitu kerangka pemecahan masalah; diskusi; sosialisasi penyuluhan; khalayak sasaran yakni perangkat desa, ketua pokja sandang dan kesehatan, ibu-ibu PKK; serta pelaksanaan kegiatan. Bentuk penyuluhan berupa edukasi pangan sehat, praktik menu sehat dan pengolahannya, serta pemaparan materi. Kegiatan penyuluhan dan edukasi menu sehat berjalan sukses dengan ibu-ibu kader PKK desa yang sangat antusias. Hasil kegiatan pre-test menunjukkan nilai 65–70 sebanyak 33%. Hasil post-test terdapat peningkatan menjadi 91–100 sebanyak 45%. Pendampingan dan pemantauan dilakukan oleh kader PKK kesehatan dan tim pengabdi di masyarakat secara door to door untuk mendukung keberhasilan program.
Phytochemical Analysis of Purple Sweet Potatoes (Ipomoea batatas) Roots Extract From Lawang and Kawi Mountain Cultivar, East Java, Indonesia Fajar Mustika Alam; Nia Kurnianingsih; Fatchiyah Fatchiyah
The Journal of Experimental Life Science Vol. 12 No. 1 (2022)
Publisher : Postgraduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2022.012.01.03

Abstract

Indonesia has wide cultivation of purple sweet potatoes (PSP) commodities, particularly in East Java province. However, the difference of phytochemical profiles in PSP among geographical regions has not been fully explored. This study aimed to analyze the phytochemicals, anthocyanin, and antioxidant activity profiles from two different cultivars of PSP from Lawang and Kawi Mountain region, East Java, Indonesia. The acidified methanol extract was identified for a phytochemical compound using standard methods. Antioxidant activity was analyzed using a ferric reducing assay. Anthocyanins were screened using ultraviolet-visible spectroscopy and total calculation. Both extracts have positive values in their alkaloid, phenolic, flavonoid, glycoside, and tannin content. Antioxidant activity was high with IC50 value 2.5 and 2.3 µg. mL-1 for Lawang and Kawi Mountain, respectively. Each cultivar has a similar peak at 521 nm at pH 1 and 530 nm at pH 4.5. Total anthocyanin calculation was showed that Lawang has higher anthocyanin content than Kawi Mountain cultivar. We concluded that PSP from Lawang has better anthocyanin content than the Kawi Mountain cultivar. We proposed that PSP from the Lawang cultivar has the potential to be explored in further research and health-related product development.
Front Matter JSMartech Vol.03., No.02 Fatchiyah, M.Kes., Ph.D
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 3 No. 2 (2022): JSMARTech Volume 3, No. 2, 2022
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2022.003.02.35

Abstract

Study of Flavonoid in Apium graveolens L. as a Kirsten Rat Sarcoma Protein Inhibitor in Colorectal Cancer Based on In Silico Study Abdullah Abdullah; Nenis Try Melani Putri; Nuraini Rosyadah; Putri Ramadhani; Siti Aqila Kharisma Putri; Muhammad Hermawan Widyananda; Nia Kurniawan; Fatchiyah Fatchiyah
Biotropika: Journal of Tropical Biology Vol. 11 No. 2 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.02.07

Abstract

Colorectal cancer (CRC) is considered the second deadliest cancer, mainly caused by the mutation of Kirsten Rat Sarcoma (KRAS) type G12D; it’s still undruggable. Flavonoids are secondary metabolites in celery, consisting of apigenin, luteolin, quercetin, and kaempferol. This study aims to analyse the most potential flavonoid compounds in Apium graveolens L. as KRAS inhibitors in CRC with in-silico. This study starts by collecting the 3D structure, Compound ID, formula, and canonical SMILES of compounds from PubChem and the 3D structure of KRAS G12D from the RCSB-PDB. Ligand and protein preparations using OpenBabel PyRx and Biovia Discovery Studio 2019. The SwissADME web server is used to analyse drug-likeness, the PassOnline web server is used to analyse biological activity, docked using PyRx VinaWizard, and visualisation by Biovia Discovery Studio 2019. RMSD and RMSF values were obtained by analysing binding stability with the YASARA application. The molecular docking test showed that chrysoeriol, luteolin, and apigenin have the highest binding affinity and advance to molecular dynamic test. Results of the molecular dynamic showed that chrysoeriol could potentially inhibit the KRAS protein drug in CRC since it also had the lowest toxicity and the strongest binding affinity to the KRAS.
Phylogenetic Analysis of UreABC Protein in Ureolytic Bacteria as Self-Healing Agent in Concrete Amalia Danti Safa Audia; Else Vilia Setiawan; Giral Baines Mora; Grace Christy; Nabila Shafa Yumna Salsabila; Firda Nuri Asyhari; Turhadi Turhadi; Fatchiyah Fatchiyah
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 4 No. 2 (2023): JSMARTech Volume 4, No. 2, 2023
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2023.004.02.49

Abstract

Concrete is one of Indonesia's most widely used materials in infrastructure development because it is strong enough to withstand pressure, adaptable, and has relatively low maintenance costs. Bacteria are potential agents that can be used to close cracks in concrete. Therefore, this research is aimed to determine which bacteria can produce the enzyme urease based on constructing a phylogenetic tree, the ability to produce spores, and the characteristics of ureolytic bacteria. This study used four sequences of ureolytic bacteria that code for ureABC, namely Bacillus, Clostridium, Pseudomonas, and Enterobacter, with Micrococcus terreus as the outgroup. The four bacterial groups with outgroups were aligned and phylogeny constructed using the Neighbor-Joining (NJ) method with 1000 replication and grouped based on genetic distance in MEGA-X software. Then further screening was carried out based on the ability to form endospores and the characteristics of ureolytic bacteria. Phylogenetic analysis shows that the bacterial groups Bacillus, Enterobacter, Clostridium and Pseudomonas have a fairly close kinship, the construction is based on proteins, genus, cell shape, gram characteristics, and habitat. The ureolytic bacteria group predicted to have the highest potential as a biomaterial agent comes from Bacillus sp. and Clostridium sp. due to its ability to form endospores. Ureolytic activity is indicated by an increased pH value and urea degradation activity due to ammonification with Bacillus sp. having a pH of 6.0-8.0. In contrast, the pH value of Clostridium sp. is unknown because further research is needed in vitro.
A Virtual Inhibition of Anti-diabetic Activity of Bioactive Compounds in Harp (Sandoricum koetjape (Burm. f.) Merr.) Elvina Rashida Khairi; Rahmi Izzati; Raissa Kendra Ainiyah; Salma Wahid Marseti; Nuraini Rosyadah; Turhadi Turhadi; Fatchiyah Fatchiyah
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 4 No. 2 (2023): JSMARTech Volume 4, No. 2, 2023
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2023.004.02.41

Abstract

The prevalence of type 2 diabetes mellitus (DMT2) has increased worldwide over the last 3 decades. This prompted the researchers to consider the medical benefits of plants, including harp (Sandoricum koetjape). In Indonesia, harp is a common medicinal herb used to cure fever, colic, vaginal discharge, diarrhea, and bloating. harp also contains substances like flavonoids, tannins, or quinones that have anti-diabetic properties. This study aims to determine the potential compound from the harp plant in inhibiting the breakdown of sugar using molecular docking to minimize the buildup of sugar in the blood. Bioactive compounds of harp were obtained from earlier studies and collected from KNApSAcK database. The physicochemical properties of the compounds were analyzed by using SwissADME and PASS Online. Using the CB-Dock server and the receptors α-amylase and α-glucosidase retrieved from RCSB PDB, along with acarbose as a control, the selected compounds were examined for their molecular interactions and binding affinities. Molecular interactions were visualized using Biovia Discovery Studio 2019. The result showed that three compounds were discovered to show potential as antidiabetic medicines out of the 54 active compounds that were screened using SwissADME. Those three compounds are sandorinic acid A, sandorinic acid B, and quercetin with the absolute value of free binding energy ranging from -7.2 to -9.6 kcal/mol. By targeting residues found in amylase and glucosidase, sandorinic acid A, sandorinic acid B, and quercetin have binding sites that are similar to acarbose. The three bioactive compounds quercetin, sandorinic acid a, and sandorinic acid b that are found in harp are expected to have the potential to be agents of type 2 diabetes mellitus.
Co-Authors Abdullah Abdullah Amalia Danti Safa Audia Ary Mustofa Ahmad Damai Aulia Nurmasari Davy Reyhanditya Eko Suyanto Else Vilia Setiawan Elvina Rashida Khairi Ernanin Dyah Wijayanti Fajar Mustika Alam Firda Nuri Asyhari Giral Baines Mora Grace Christy Irfan Mustafa Istiftakhun Nikmah Lidwina Faraline Triprisila Lidwina Faraline Triprisila Muhammad Hermawan Widyananda mulyati mulyati Nabila Shafa Yumna Salsabila Nenis Try Melani Putri Nia Kurnianingsih Nia Kurnianingsih Nia Kurnianingsih Nia Kurniawan Nia Kurniawan Nuraini Rosyadah Nuraini Rosyadah Nuri Masruro Putri Ramadhani Rahmi Izzati Raissa Kendra Ainiyah Rista Nikmatu Rohmah Rista Nikmatu Rohmah Safitri, Anna Salma Wahid Marseti Siti Aqila Kharisma Putri Takahisa Yamada Takashi Ohta Tri Wahyu Nugroho Turhadi Turhadi Viona Faiqoh Hikmawati Yeni Avidhatul Husnah