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Academia Open
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 27147444     DOI : https://doi.org/10.21070/acopen
Core Subject : Economy, Humanities, Health, Science, Education, Agriculture, Art, Social,
Agriculture, Biological Sciences & Forestry Arts Humanities Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Physics Social Sciences Other
Academia Open is published by Universitas Muhammadiyah Sidoarjo published 2 (two) issues per year (June and December). This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. This journal aims is to provide a place for academics and practitioners to publish original research and review articles. The articles basically contains any topics research or review. Academia Open is available in online version. Language used in this journal is Indonesia or English. Academia Open is an open access journal publishing scientifically accurate and valuable research across life, physical, social, and medical sciences.
Arjuna Subject : Umum - Umum
Articles 855 Documents
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Circulating Microrna-146a as A Biomarker Related To Inflammation in Thalasemia Patients Heba Hani Hamzah; Nawal Khinteel Jabbar
Academia Open Vol 9 No 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8120

Abstract

This study delves into the intricate realm of microRNAs (miRNAs), non-coding RNA molecules that wield significant influence in the pathogenesis of various disorders. With the advent of advanced technologies, accurate quantification of miRNA abundance across diverse tissues is now attainable. Notably, extracellular circulating microparticles have emerged as robust, stable indicators for blood-based disease diagnostics. This investigation explores the dynamic interplay between circulating microparticles and clinical phenotypes, offering valuable insights into disease intricacies. The research narrows its focus to recent developments in employing circulating microparticles as biomarkers for prevalent inflammatory disorders, including infections endemic to thalassemia patients in the city of Diwaniyah, Iraq. Current findings paint a promising future for the utilization of circulating microparticles in the management of inflammatory diseases. In conclusion, this comprehensive exploration of miRNA's regulatory role in globin gene expression has the potential to revolutionize the landscape of thalassemia, ameliorating clinical manifestations and symptoms of this debilitating hemoglobinopathy. The identification of miRNAs implicated in the disease's pathophysiology not only paves the way for novel diagnostic markers but also opens new horizons for therapeutic interventions. Highlights : MiRNA Significance: MicroRNAs play a pivotal role in the pathogenesis of various disorders, offering potential insights into disease mechanisms. Circulating Microparticles: Extracellular circulating microparticles are stable blood-based indicators, holding promise for disease diagnostics and management, especially in the context of inflammatory disorders. Thalassemia Insights: This study highlights the potential impact of miRNAs on globin gene expression, offering new avenues for the diagnosis and treatment of thalassemia, a debilitating hemoglobinopathy. Keywords : MicroRNAs (miRNAs), Circulating Microparticles, Thalassemia, Inflammatory Disorders, Disease Diagnostics
Novel Synthesis of Thiopyrimidine Compounds from Dibenzo-18-Crown-6 and Evaluation of Antibacterial Activity Zena Abdali; Raheem Jameel Mahesein
Academia Open Vol 9 No 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8121

Abstract

In this study, we present a novel synthesis approach for the production of thiopyrimidine compounds, including P-OH-Thiopyrimidine, P-NO2-Thiopyrimidine, and P-Cl2-Thiopyrimidine, from the precursor compound dibenzo-18-crown-6 (DB-18-CE-6). These thiopyrimidine compounds have shown significant potential for various applications, particularly as antibacterial agents. The synthesis involved the reaction of DB-18-CE-6-derived alpha-beta unsaturated ketones with thiourea in a basic medium, resulting in successful cyclization. The synthesized thiopyrimidine compounds were evaluated for their antibacterial activity against common bacterial strains, including Streptococcus, Staphylococcus, and Proteus, and compared to the antibiotic Azithromycin. The results demonstrated that the thiopyrimidine compounds (Z, Z1, Z2, Z3) exhibited excellent antibacterial activity, surpassing Azithromycin, and highlighting their potential as effective alternatives to combat bacterial infections. This research opens new avenues for the development of antibacterial agents and emphasizes the significance of thiopyrimidine compounds in addressing bacterial resistance issues. Highlights : Novel synthesis of thiopyrimidine compounds from DB-18-CE-6. Evaluation of antibacterial activity against Streptococcus, Staphylococcus, and Proteus. Potential of thiopyrimidine compounds as effective antibacterial agents. Keywords : Thiopyrimidine compounds, Antibacterial activity, DB-18-CE-6, Novel synthesis, Bacterial resistance.
Exploring Hemingway's Depiction of War Violence: Psychological and Societal Impacts in Selected Novels Emad Mohammad Abbar
Academia Open Vol 9 No 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8127

Abstract

This study delves into the portrayal of war violence in four seminal novels by Ernest Hemingway, namely, "A Farewell to Arms," "For Whom the Bell Tolls," "The Sun Also Rises," and "To Have and Have Not." Employing a qualitative analysis, this research categorizes instances of war violence based on thematic implications, narrative techniques, and character responses, while considering contextual information from Hemingway's own wartime experiences. The analysis unveils that Hemingway's exploration of war violence transcends the physical battlefield, emphasizing the profound psychological traumas, moral quandaries, and societal scars it inflicts. Characters within these narratives grapple with disillusionment, existential anguish, and a sense of alienation, reflecting the multifaceted impacts of war on individuals and society. Hemingway's personal involvement in World War I and the Spanish Civil War greatly influences his portrayal of war violence, presenting it as not only an external conflict but an internal struggle that challenges ideologies, identities, and human resilience. The thematic recurrence across these novels underscores Hemingway's persistent examination of the enduring consequences of war. In essence, Hemingway's depiction of war violence serves as a lens through which to contemplate the profound psychological and societal repercussions of conflict, offering an enduring reflection on the devastating nature of war. Highlights : Qualitative analysis of Hemingway's war narratives. Psychological and moral dilemmas in war literature. Hemingway's personal experiences and their literary influence. Keywords : War Violence, Hemingway Novels, Psychological Impacts, Societal Consequences, Qualitative Analysis
Isoxazolidine Derivatives Exhibit Selective Antitumor Activity Against Breast Cancer Cells Wijdan Abbas Eneama; Husam Hamza Salman; Mazin N`adhim Mousa
Academia Open Vol 9 No 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8148

Abstract

Breast cancer, a leading cause of cancer-related mortality in women, necessitates effective therapeutic interventions. Heterocyclic compounds, prevalent in FDA-approved pharmaceuticals, play a pivotal role in drug development. This study focuses on isoxazolidine derivatives, a subgroup of nitrogen and oxygen-containing heterocycles, known for their potential in antitumor applications. A series of novel isoxazolidine compounds were synthesized and evaluated for their anticancer efficacy using MTT assays against MCF-7 and HdFn cell lines, alongside normal cells. Structural elucidation employed FT-IR, 13C-NMR, 1H-NMR, and E-I mass spectroscopy. Results revealed compound (IZ3) with an IC50 value of 32.49 µg/ml, demonstrating notable antitumor activity in MCF-7 cells compared to HdFn. Notably, compounds (IZ1 and IZ2) exhibited IC50 values of 64 µg/ml and 128 µg/ml, respectively. These findings underscore the potential of isoxazolidine derivatives as promising candidates for targeted breast cancer therapies, warranting further investigation in preclinical models and clinical trials. Highlight: Novel Isoxazolidine Compounds: Synthesized and Evaluated Selective Antitumor Activity: Demonstrated in MCF-7 Breast Cancer Cells Promising Therapeutic Candidates: Isoxazolidine Derivatives for Targeted Breast Cancer Therapy Keyword: Breast cancer, Isoxazolidine Derivatives, Antitumor Activity, Heterocyclic Compounds, Drug Development
Comparative Analysis of Lutein Content in Leaves and Fruit of Lycium barbarum: Implications for Medicinal Applications Omaima Saddam Zirjawi; Ula M Noor Almousawi; Amjed Haseeb Khamees
Academia Open Vol 9 No 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.8158

Abstract

Herbal medicine stands as a pivotal realm of contemporary research, offering substantial benefits with minimal side effects. Lycium barbarum, recognized for its abundant bioactive compounds, holds promise in treating various ailments, particularly in antiaging and antioxidative capacities. Carotenoids, notably lutein and zeaxanthin, constitute key bioactive compounds with diverse functions in both plant physiology and human health, including photo protection against intense light and detoxification of reactive oxygen species. This study meticulously examines the lutein content within leaves and fruit of L. barbarum, employing a uniform extraction method and solvent. The investigation illuminates significant variations in lutein content between the leaves and fruit, shedding light on potential applications in herbal medicine and nutraceuticals. Highlight: Herbal Medicine Advancements: This study underscores the pivotal role of herbal medicine in contemporary research, emphasizing its potential for providing substantial benefits with minimal side effects. Lycium barbarum's Therapeutic Potential: The research highlights Lycium barbarum's significance due to its rich array of bioactive compounds, particularly in addressing antiaging and antioxidative requirements. Bioactive Carotenoids in Focus: The study delves into the functions of essential bioactive compounds, lutein and zeaxanthin, elucidating their roles in plant physiology and human health, including their photoprotective and detoxifying properties. Keyword: Herbal Medicine, Lycium Barbarum, Bioactive Compounds, Carotenoids, Lutein Content

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