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Syafura Az-Zahra
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INDONESIA
Berkala Ilmiah Mahasiswa Farmasi
Published by Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia
ISSN : 23027851     EISSN : 27741710     DOI : 10.48177
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
BIMFI is a peer-reviewed and open access journal that prioritize the publication manuscript of pharmaceutical and health cluster students. This journal publishes editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. BIMFI receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutics, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
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Search results for , issue "Vol 8 No 2 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)" : 5 Documents clear
STUDI LITERATUR PEMANFAATAN SINTESIS SENYAWA PIPERIDINIL-P-KUMARAMIDA DARI ASAM-P-KUMARAT YANG DIPEROLEH DARI LIMBAH SEKAM PADI (ORYZAE SATIVA) SEBAGAI OBAT ANTI KANKER LEUKEMIA Athalia Theda Tanujaya; Steven Steven; Norman Emil Ramadhan
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 2 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i2.43

Abstract

Introduction: In 2018, the incidence of cancer in Indonesia reached 136.2 per 100,000 population and leukemia cancer was in the fifth position as the deadliest cancer and has killed 11,314 lives. The high cost of treating leukemia has costed the funding budget in the JKN-KIS program up to Rp3.4 trillion. Researchers have tried to use natural ingredients to develop new anti-leukemia agents. Content: One of the compounds that can inhibit leukemia cancer is piperidinyl-p-coumaramide, a derivative of p-coumaric acid which can be found and isolated from rice plant waste or Oryzae sativa. Each year, 79.2 million tons of rice are produced and generate 19.8 million tons of husk. The aim of this article is to utilize rice husk as a piperidinyl-p-coumaramide precursor for leukemia drug. Method: The method used was stratified extraction of the husk waste using a water-methanol and ethyl acetate solution. The extract was then isolated and purified by TLC. After that, the assay was analyzed using HPLC. P-coumaric acid is modified into piperidinyl-p-coumaramide by reacting it with piperidine. Conclusion: The activity of piperidinyl-p-coumaramide as an anti-leukemic cancer on p388 cells can be tested in vitro and in vivo. According to the literature study, 100 grams rice husk may generate 265.4 ± 2.4 milligrams p-coumaric acid that can be synthesized into piperidinyl-p-coumaramide which has IC50 around 5,34 µg/mL thus can be utilized as an anti-leukemia cancer.
SITRUS: INOVASI SABUN KERTAS BERBASIS LIMBAH KULIT JERUK DI TENGAH PANDEMI COVID-19 Darren Lie; Fairuz Aisya Alzura
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 2 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i2.57

Abstract

Introduction: Since there is no effective curative or vaccine for COVID-19 yet, preventive action will be prioritized to reduce the spread of the SAR-CoV-2 virus. One of the preventive actions is the development of cosmeceutical dosage form, which is soap, that acts as a surfactant to remove dirt and microorganism so it can destroy virus viability. On the other hand, the increasing amount of citrus peel waste in Indonesia and the importance of soap for preventive action is the motivation and reason to develop Sitrus (Citrus soap), a soap that is made from limonene (essential oil) from citrus peel waste and packed in form of paper soap (solid soap that is printed in thin and small size like a sheet of paper and will dissolve and produce foam when mixed with water). Content: Component from peel waste has antimicrobial activity through the mechanism of limonene accumulation at the plasma membrane of cell membrane, which causes integrity instability and disrupts electrochemical gradient at the cell membrane. The essential oil from citrus peel waste can be obtained by steam distillation and will be used with the total amount of 3% in Sitrus formulation. Other components in the formulation are NaOH 30% solution with the total amount of 25% as a base component in soap, stearic acid with the total amount of 11% as neutralizer, ethanol 96% solution with the total amount of 18% as solvent, glycerine with the total amount of 15% as plasticizer, and water for solvent. Sitrus is a personalized paper soap that is more economical, easy to bring everywhere and to use, not dissolved with skin components such as lipids, and has double-action (cleaning and antimicrobial activity). Conclusion: Combination of both antimicrobial activity and paper soap support Sitrus for increasing the preventive action in society in the midst of COVID-19 pandemic. Sitrus in not only remove the microbe and virus in skin surface, but also reduce the negative impact of citrus waste peel accumulation Keywords: COVID-19, preventive, paper soap, citrus peel waste
STUDI LITERATUR RASIONALITAS, DAN POLA SENSITIVITAS TERHADAP ANTIBIOTIK PADA BAKTERI STAPHYLOCOCCUS AUREUS PENYEBAB INFEKSI GANGREN DIABETES MELITUS Aprilia rina wati; ismi rahmawati; Inaratul Rizkhy Hanifah
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 2 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i2.78

Abstract

Introduction: Diabetic gangrene can be treated with antibiotics. The use of antibiotics must be done rationally. Antibiotic sensitivity patterns know which antibiotics have become resistant. The purpose of this literature study is to determine the relationship between rationality and patterns of antibiotic sensitivity in bacteria that cause gangrene infection. Methods: The research was conducted using a literature study method using journals obtained through journal sites such as search engines Scopus, Google Scholar, ScienceDirect, NCBI, PubMed, Oxford Academics, Cambridge, and Sprinkle link published between 2009-2021, obtained journals as many as 13 journals extracted from 99 existing journals. This literature study was carried out in several stages, namely, formulating problems, collecting data, extracting data, synthesizing data, and compiling a thesis. Result: The results of the literature study rationality of antibiotic use is precise indication, appropriate drug and appropriate patient. Antibiotics that are resistant in several hospitals in Indonesia are ceftriaxone, cotrimoxazole, benzylpenicillin erythromycin, ampicillin, cloramfenicol, cefoperazone, meropenem, cefixime, gentamicin, ceftazidime, ciprofloxacin, streptomycin, lincomycin, and cefotaxime. The mechanism that bacteria have in developing resistance is by enzymatic modification, changes in PBP structure, pump protein production, and changes in antibiotic targets
NARRATIVE REVIEW: MONSTERA DELICIOSA SEBAGAI ANTIBAKTERI DALAM SEDIAAN SPRAY HYDROGEL 3 IN 1 Regina Desyca Sarmitha Dewi; Miftahul Janna; La Ode Muh Alfiqra; Selpirahmawati Saranani
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 2 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i2.79

Abstract

Introduction: Monstera deliciosa have the potential to be developed as anti-bacterial drugs due to secondary metabolite compounds such as tannins, steroids, saponins, flavonoids and alkaloids. The purpose of this review is to demonstrate potential of Monstera deliciosa as an antibacterial in spray hydrogel 3 in 1 spray dosage form. Methods: This narrative review conducted the method of literature review or the secondary data compilation from several scientific journal such as wiley, sciencedirect, portal garuda, and google scholar. Result: Monstera deliciosa have several volatile components that have been shown antibacterial activity included 1,6-Cyclodecadiene, 6,10,14-trimethyl-2-Pentadecanone, naphthalene, limonene, 1–methyl–5–methylene–8-(1-methylethyl), and 2-Furanmethanol so it can be used as an antibacterial agent in spray hydrogel 3 in 1 spray dosage form. Conclusion: Monstera deliciosa have the potential to be developed as anti-bacterial in hydrogel 3 in 1 preparation.
REVIEW ARTIKEL : TANAMAN YANG MEMILIKI AKTIVITAS ANTI-ULSER DI ASIA Nabila Putri Azzahra; Kirka Dwi Apriali1; Lika Ginanti Febriana
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 2 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i2.80

Abstract

Introduction : Herbal medicines have high potential in treating various diseases including gastric ulcers because they are considered safer and more comfortable. Ulcers or gastric ulcers are disorders of the stomach due to an imbalance of aggressive factors (gastric acid secretion, pepsin, and Helicobacter pylori infection) with defensive factors (prostaglandins, mucus, bicarbonate, mucosal blood flow, and intrinsic epithelial cells). Methods : The method used is a literature review study conducted by searching for keywords such as peptic ulcer disease, herbal plants, anti-stomach ulcers, and others in databases such as PubMed and Google Scholar. Results : From the literature review, 29 medicinal plants in Asia have a potential anti-ulcer activity that can prevent and help treat gastric ulcers. The table of medicinal plants is arranged based on the phytochemical analysis, the part used, and the country where the plant originates. Conclusion : Plants that have the potential to prevent and help heal gastric ulcers that are spread in Asia include phytochemicals containing flavonoids, tannins, polyphenols, alkaloids, glycosides, terpenoids, saponins with various mechanisms, namely gastroprotective, antioxidant, anti-inflammatory, anti-secretory, anti-Helicobacter. pylori, and astringents.

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