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Berkala Ilmiah Mahasiswa Farmasi
Published by Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia
ISSN : 23027851     EISSN : 27741710     DOI : 10.48177
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
BIMFI is a peer-reviewed and open access journal that prioritize the publication manuscript of pharmaceutical and health cluster students. This journal publishes editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. BIMFI receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutics, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
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Search results for , issue "Vol 9 No 2 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)" : 5 Documents clear
TINJAUAN PUSTAKA : SEJARAH HIV (HUMAN IMMUNODEFICIENCY VIRUS) HINGGA PERKEMBANGAN VAKSINASI GLOBAL wil hel minah
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 2 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i2.96

Abstract

ABSTRACT HIV (Human Immunodeficiency Virus) is a virus that damages the immune system by infecting CD4 cells (cluster of differentiation 4) which is an important part of the immune system. Damage to the immune system causes humans to lose their immune system so they are easily infected and die [1] . In March 2021, HIV cases were still increasing, as many as 427,201 people with HIV cases, and as many as 131,417 people with AIDS cases. The number of patients taking antiretroviral treatment was 269,289 people, 219,898 people were still alive and 49,391 people had died [2]. Until now there is no vaccine that can be used for HIV treatment, this trial has not succeeded in developing a working vaccine [3] . The purpose of this review is to explain the history of the development of HIV to the development of vaccines as technological updates for HIV treatment. The main challenges faced by this trial were the high antigenic variation of HIV, the presence of a latent HIV reservoir, and the difficulty of eliciting a broad neutralizing antibody response [4]. Currently, the strategy of making vaccines using traditional methods, namely Live attenuated virus, inactivated virus is not recommended for HIV treatment. Researchers have explored a new approach, namely mRNA vaccines. With this vaccine strategy it has been proven safe and effective to elicit CTLs (Cytotoxic T Lymphocytes) responses. Currently the HIV mRNA vaccine candidate from the company Moderna on August 18, 2021 has entered a phase 1 clinical trial in humans finding that 97% of people who received the vaccination had an appropriate immunological response. Keywords : Human Immunodeficiency Virus, Acquired immunodeficiency syndrome, Antiretroviral, HIV Vaccine, Self-amplifying.
UJI BIOINFORMATIC MODELING SENYAWA AKTIF BIJI MELINJO (Gnetum gnemon L.) PADA PROTEIN KANKER SERVIKS DAN SARS COV-2 Dhecella Winy Cintya Ningrum; Devi Rahmawati; Rifki Febriansah; Melany Ayu Octavia
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 2 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i2.98

Abstract

Introduction: Cervical cancer cases in Indonesia are ranked second with the results ofdata in 2020 of 36,633 cases. During the COVID-19 pandemic, cancer patients aresusceptible to being infected by COVID-19. Study data from China, February 2020, therewere 107 cancer patients infected with COVID-19. It should get more attention becauseweakened immune form cancer patients. The purpose of this study was to determine thepotential of active compounds from melinjo seeds in inhibiting cervical cancer proteins andSARS CoV-2. Methods: The method used is bioinformatics test (STITCH -STRING) and moleculardocking test using Autodock Vina. The results will be seen from the lowest docking score.Result: The results of the bioinformatics test were obtained in the form of target proteinsfor cervical cancer regulators, namely MYC and TP53 (Resveratrol), FN1 and MAPK1(Gnetin C), SERPINE1 and VEGFA (Oleic Acid). The results from the analysis of thebinding affinity a target protein obtained the best binding affinity for cancer proteins, namelyGnetin C with FN1 with a docking score of -10.8 kcal/mol. The best affinity for SARS CoV2 protein after Remdesivir was for Resveratrol and Nsp3 with a docking score of -7.4kcal/mol. Conclusion: The results showed that the active compounds Resveratrol and Gnetin C hadgood potential in inhibiting cervical cancer protein and SARS CoV-2 with a lower dockingscore compared to the comparison drug Keywords: Gnetum gnemon L, bioinformatic modeling, cervical cancer, SARS CoV-2
Tinjauan Pustaka: Karakteristik Dan Respon Antibodi Vanksin Dengan Sediaan Microneedle Patch Lika Ginanti Febriana
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 2 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i2.99

Abstract

Introduction: Vaccination is one of the greatest medical advances of modern preventive medicine. Vaccination is the most effective way to control the incidence of infectious diseases. However, the current vaccination approach faces a number of challenges that impact vaccination compliance. Most vaccines given by intramuscular (IM) or subcutaneous (SC) injection cause pain and discomfort, in most cases, leading to poor adherence due to needle phobia. The development of microneedle patch technology has been applied to various types of vaccines. Methods: The research method used is literature review. The literature sources used in this study were searched through the PubMed® and Google Scholar databases with the keywords microneedle vaccine, vaccine patch, and microneedle patch vaccine. Found 20 articles that can be used in the literature review Result: The results of research on the microneedle patch from various types of vaccines need to be studied to determine the effectiveness of the vaccine in the form of a microneedle patch. Various aspects such as the type of microneedle patch, needle height, and antibody response to vaccine preparations in the form of a microneedle patch can be indicators to assess the potential of a microneedle patch. Conclusion: Various aspects such as the type of microneedle patch, needle height, and antibody response to vaccine preparations in the form of a microneedle patch can be used as indicators to assess the potential of a microneedle patch. There are four types of microneedle, namely Solid Microneedle, Coated Microneedle, Dissolving Microneedle, and Hollow Microneedle. To penetrate the skin, the microneedle has a pointed tip with a length of 150-1500 m, a width of 50–250 m, and a tip thickness of 1–25 m. Microneedle patch can induce antibody formation to be faster.. Keywords: Microneedle Patch, Vaccine, Vaccination
PENETAPAN KADAR ASAM RETINOAT PADA KRIM MALAM YANG DI JUAL BEBAS DI KOTA PEKALONGAN DENGAN METODE SPEKTROFOTOMETRI UV-VIS Yusrilia Syafira
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 2 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i2.102

Abstract

Retinoic acid is one of the essential compounds added to night cream as it can remove dead skin cells, resulting in a white effect on the skin. However, it has a dangerous risk on the skin, which can cause inflammation, such as burning, stinging, redness, erythema, and hardening skin, and carcinogens if used for more than 6 months in a row. This study aimed to analyze the content of retinoic acid and determine its levels of retinoic acid. The samples selected were 10 night cream products circulating in Pekalongan City. This research was conducted qualitatively using thin layer chromatography with the mobile phase of n-hexane and 1% glacial acetic acid in ethanol (9:1). In the quantitative aspect, this study used UV-Vis spectrophotometry. The results obtained in thin layer chromatography obtained that the sample Rf value was the same as the standard Rf value of retinoic acid, which was 0.28, while the samples E, F, G, H, I, and J were 0.28. The UV-Vis spectrophotometry obtained retinoic acid levels that exceed the standard level from the National Food and Drug Agency (BPOM), which is 0.05%. The retinoic acid level of sample E was 0.08%, and sample F was 0.09%, respectively.
The Ketepatan Penyimpanan Obat High Alert Medication di Instalasi Farmasi RSUD Dr. Soegiri Lamongan Hifar Rahmadinah
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 2 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i2.103

Abstract

Rahmadinah, H. 2022. Accuracy of Storage of High Alert Medication in the PharmacyInstallation of RSUD Dr. Soegiri Lamongan 2022. Thesis. Pharmacy StudyProgram, Faculty of Medicine and Health Sciences, Maulana Malik IbrahimState Islamic University, Malang. Supervisor I : apt. Hajar Sugihantoro,S.Farm., M.P.H.; Supervisor II : apt. Ah. Syahrir, M. Farm.High Alert Medication (HAM) is a group of drugs that need to be watched out for in theiruse because they can lead to high use of unwanted drugs (Medication Error). The highalert medication group is divided into LASA (Look A Like Sound A Like) drugs, highlyconcentrated electrolytes, and cytostatics (cancer drugs). The purpose of this study was todetermine the profile and accuracy of storage of LASA (Look A Like Sound A like)drugs and high-concentrate electrolytes based on the issued SOPs. This research includesdescriptive research by observing, classifying, recording, and analyzing with SOPguidelines. The sample of this study used LASA (Look A Like Sound A Like) drugs andhighly concentrated electrolytes. Location The research was conducted at the pharmacyinstallation of RSUD Dr. Soegiri Lamongan in 2022. The results show that the storageprofile of LASA (Look Alike Sound A Like) and high concentrate electrolytes uses astorage method based on the storage method based on the form and type ofpharmaceutical preparations, FIFO, FEFO, and alphabetically. The storage accuracy ofLASA drugs (Look Alike Sound A Like) for indicators of separated LASA drugs withtheir equivalents is 97.72% and LASA drugs labeled "LASA" with a yellow base is90.9%. Accuracy of high-concentrated electrolyte drug storage for indicators Highconcentrated electrolyte medicine is labeled “High Alert” at 100% and high-concentratedelectrolyte medicine is labeled “Concentrated Electrolyte” with a yellow base color of100%. Based on these results, it can be concluded that the LASA (Look Alike Sound ALike) storage has not met the accuracy based on the issued SOP.Keywords : LASA (Look A Like Sound A Like), high concentrate electrolyte,Medication Error

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