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Current Research on Biosciences and Biotechnology
Published by Institut Teknologi Bandung
ISSN : -     EISSN : 26861623     DOI : https://doi.org/10.5614/crbb
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Materials Science & Nanotechnology Medicine & Pharmacology
The Current Research on Biosciences and Biotechnology (CRBB) encourages researchers to publish works related to the use of the biosciences and biotechnology in understanding the world around us. From Health and Medicine to Advanced Materials, these state-of-the-art research offer novel insights in a multidisciplinary environment. We encourage scientists to submit papers focusing on the following broad topics: Health and Medicine Pharmaceutical Sciences Pharmacology and Toxicology Food Microbiology and Biotechnology Biotechnology Agriculture Bio-Energy Marine Sciences Advanced Materials Environmental Sciences
Arjuna Subject : Umum - Umum
Articles 5 Documents
 1 
Search results for , issue "Vol. 3 No. 1 (2021)" : 5 Documents clear
A study of genus Zingiber: the role of condiments in science Anggra Paramita; Indra Wibowo; Muhammad Insanu
Current Research on Bioscences and Biotechnology Vol. 3 No. 1 (2021)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2021.3.1/CKHEYSRT

Abstract

Zingiberaceae family has been widely used as an herbal medicine from generation to generation. The literature review of Zingiber genus, which is part of Zingiberaceae, was conducted to provide information and to determine the correlation between bioactive compounds and pharmacological properties with their empirical uses. Articles about genus Zingiber were collected from online databases (e.g., Directory of Open Access Journal, PubMed, ResearchGate, ScienceDirect, and Springer), they were sorted based on inclusions criteria such as related to bioactive compounds and biological activities of the samples and also articles for the last ten years. Merely articles with DOI were reviewed. The screening process resulted in 52 reports being reviewed and grouped based on each plant's bioactive contents and pharmacological properties. The major constituents in genus Zingiber are essential oils. Therefore, the dominant activities found in this genus was related to antimicrobial and antioxidant. Furthermore, the other activities of plants were related to the bioactive compounds and their current uses. The empirical uses of these rhizomes were in line with the bioactive compounds and biological activities.
Antibacterial activity of secondary metabolites isolated from Ficus aurata (Miq.) Fruits Nurhamidah Nurhamidah; M Lutfi Firdaus; Suryati Suryati; Yosie Andriani
Current Research on Bioscences and Biotechnology Vol. 3 No. 1 (2021)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2021.3.1/A2F9IMF6

Abstract

This research aimed to isolate chemical constituents from ethyl acetate and n-hexane fractions of Ficus aurata (Miq.) fruits and investigated their antibacterial activity. Chemical constituents were separated using vacuum liquid chromatography, gravity column chromatography, and thin-layer chromatography. The structures of the isolated compounds 3,4-dihydroxybenzoic acid (1) and β-sitosterol (2) were elucidated using various spectroscopic methods, including UV, IR, and NMR (1H-NMR, 13C-NMR, and DEPT). While, antibacterial activity was done using resazurin microtiter assay. These 2 compounds were first time reported from F. aurata fruit. In addition, analysis of the bioassay showed that compound 1 had a notable antibacterial activity against Gram negative (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATTC 27853), and a gram-positive bacterium (Staphylococcus aureus ATCC 23235) with the minimum inhibitory concentration (MIC) value of 0.1563 µg/ml, and it indicated the same MIC as cefadroxil (positive control). Compound 2 has weak antibacterial activity compared to cefadroxil (positive control). The results found that F. aurata (Miq.) fruits metabolites have antibacterial activity and show potency as antibacterial agents. Different kinds of bacteria and assay could be needed to investigate and support its antibacterial activity in the future.
Mitragynine: a review of its extraction, identification, and purification methods Amrianto; Sumail Sidik Ode Ishak; Nanda Putra; Syefira Salsabila; Laode Muhammad Ramadhan Al Muqarrabun
Current Research on Bioscences and Biotechnology Vol. 3 No. 1 (2021)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2021.3.1/TMPNSA4H

Abstract

Mitragynine is one of the dominant alkaloids present in Mitragyna speciosa. The compound possesses several pharmacological properties such as antinociceptive, anti-inflammatory, and anti-cancer. Studies have reported various methods in extracting mitragynine, both conventional and renewable technology combined with acid-base techniques for the enrichment and purification of mitragynine from M. speciosa. Several chromatography and spectroscopy instruments such as HPLC, LC-MS, GC-MS, and NMR have been used to identify mitragynine and its content in both the extract and fraction mixtures. In this review, we aim to provide insight on how the methods of extraction, purification, and identification of mitragynine have been developed over the last few decades. This report shows comparison among the various approaches in extracting mitragynine and points out the facts that different methods gave different yields of the compound.
Proximate and biological activity studies of Syzygium samarangense: Study of different extractives of Syzygium samarangense Tirthankar Biswas; Md. Al-Amin; Mohammad Shoeb; Md. Kamrul Hasan; Md. Nazrul Islam; Md. Mizanur Rhaman
Current Research on Bioscences and Biotechnology Vol. 3 No. 1 (2021)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2021.3.1/NKTEH76W

Abstract

Red and green varieties of Syzygium samarangense, commonly known as Jamrul, are very popular as seasonal fruits to all ages of people in Bangladesh. Objective of the work was chemical and biological activity studies of S. samarangense red and green varieties grown in Bangladesh. Air-dried fruits of S. samarangense were successively extracted with n-hexane, dichloromethane (DCM) and methanol. The moisture and ash content of the raw fruits were determined by thermal heating at 105 and 700℃, respectively. Different biologically important functional groups were identified by FT-IR spectroscopy. The n-hexane, DCM and methanolic extracts were tested for cytotoxicity against HeLa and Vero cell lines. Total phenolic content, total flavonoid content and total antioxidant capacity in the three extracts of both varieties were determined. The moisture content and ash content were 92% and 90%, and 0.12% and 0.16% in red variety and green variety, respectively. UV-Vis spectrum revealed the presence of long chain conjugation or polycyclic aromatic chromophores in n-hexane, DCM and methanolic extracts of S. samarangense. The DCM extract of both varieties had highest total phenolic content, flavonoid content and antioxidant capacity compared to n-hexane and methanol extracts. The study concludes that the fruit of S. samarangense (red and green variety) grown in Bangladesh are rich source of phytochemicals which possess antioxidant activity and safe to health for their non-cytotoxic properties. The green variety contains more phenolic content and antioxidant capacity than red variety.
Ursodeoxycholic acid: a systematic review on the chemical and biochemical properties, biosynthesis, sources and pharmacological activities Marlin Megalestin Raunsai; Elfahmi; Agus Chahyadi; Sony Suhandono; Tati Kristianti; Laode M.R. Al Muqarrabun
Current Research on Bioscences and Biotechnology Vol. 3 No. 1 (2021)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2021.3.1/UJZVBNA0

Abstract

Ursodeoxycholic acid (UDCA), a secondary bile acid (BA), is an acidic steroid synthesized from cholesterol in hepatocytes. UDCA is widely used for the treatment of various diseases related to liver injury. The use of UDCA to treat non-liver diseases has also been developed recently, such as neurodegenerative diseases, cancer, and obesity. Due to the important role of UDCA on human health, numerous studies in understanding its chemical and pharmacological properties have been published. Literature sources were obtained from online databases such as Science Direct, Google Scholar, Scopus and PubMed using keywords relating to the purpose of study. Critical analysis and review were performed for all literature. UDCA is a steroid compound with pharmacological properties. Seventeen enzymes are involved in its biosynthesis, which has been proposed in four pathways: classic, alternative, the Yamazaki, and 25-hydroxylation pathways. UDCA can be isolated from bovine bile, bear bile or all Ursidae, human, rabbit, cow, rat, hamster, sheep, pig, and plant. UDCA has been used in the treatment of several diseases such as primary biliary cirrhosis, intrahepatic cholestasis of pregnancy, hepatolithiasis associated with Caroli syndrome gallstones, cystic fibrosis, hepatitis C virus, chronic heart failure, neurodegenerative diseases, and obesity, as well as in the prevention of cancer. UDCA has a wide range of pharmacological properties. Further investigations on its efficacy and safety on humans are required before it could be used for several indications. All genes which are responsible in UDCA biosynthesis have been elucidated. That said, further genetic engineering studies in order to find other prospective sources of UDCA could be a challenge for the future research.

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