cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Nurhadiyahya
Contact Email
nurhadiyahya@ugm.ac.id
Phone
+6289672800034
Journal Mail Official
ijpther@ugm.ac.id
Editorial Address
Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada Jl. Farmako Sekip Utara, Yogyakarta 55281
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Indonesian Journal of Pharmacology and Therapy
Published by Universitas Gadjah Mada
ISSN : -     EISSN : 2745455X     DOI : https://doi.org/10.22146/ijpther.4468
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Neuroscience
Indonesian Journal of Pharmacology and Therapy (IJPTher ) is a scientific journal which managed by Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada. IJPTher is an open-access, and double-blind peer-reviewed journal published twice Issues a year. IJPTher aims to communicate high-quality articles in the fields of pharmacology. IJPTher publishes original articles, review articles, case reports and book reviews in the fields of pharmacology including basic pharmacology, clinical pharmacology, pharmacotherapy, pharmacoepidemiology, pharmacogenetics, pharmacogenomics, pharmacoeconomic, toxicology and toxicogenomics.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 4 No 2 (2023)" : 5 Documents clear
Papillary thyroid carcinoma post total thyroidectomy: a case report Darwito; Doglas Rama Bayu Ardha; Ika Puspita Sari; Firda Ridhayani
Indonesian Journal of Pharmacology and Therapy Vol 4 No 2 (2023)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.6980

Abstract

Thyroid malignancies are considered rare but it is the most common type of endocrine malignancy that increase rapidly over the past decades. Specifically, papillary thyroid carcinoma (PTC) in the pyramidal lobe is extremely rare. Herein, we described a case of recurrence case of PTC in the pyramidal lobe post total thyroidectomy with category VI T2N1M1 (Bethesda classification) with right neck lymph nodes metastasis at once and attempt to determine both clinical presentation and therapeutical strategies to overcome this case to diminish the possibility of tumor recurrence and optimize therapeutic outcomes for PTC recurrence. It was reported a 28 yo female with a diagnosis of PTC from the pyramidal lobe post-total thyroidectomy procedure. A definite diagnosis of PTC is important to understand the patient's condition and as a consideration to decide the appropriate procedure to cure it. The management of PTC with total thyroidectomy followed by removing the possible root source of recurrent PTC, such as the pyramidal lobe, is mandatory to minimize the residual thyroid tissue that dan influenced PTC recurrent. Even though almost all PTC has an excellent prognosis, periodic follow-up after surgery, and patients’ adherence to their medication are still required.
The potency of kitolod leaves (Hipobroma longiflora) as traditional medicine for conjunctivitis during the COVID-19 pandemic: a brief review Yuliana; Ni Made Ersi Dwitami Barsua; Made Wulan Virgioni Putri; I Nyoman Satya Mahayana Putra
Indonesian Journal of Pharmacology and Therapy Vol 4 No 2 (2023)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.701 KB) | DOI: 10.22146/ijpther.7542

Abstract

During the coronavirus disease 2019 (COVID-19) pandemic, most activities have transformed into digital ones, including computer usage. The digital screen on the computer has blue light radiation which can activate inflammatory cytokines of the eye surface and cause various disorders including includes conjunctivitis. Kitolod leaves (Hippobroma longiflora) have been used traditionally to treat conjunctivitis. This paper aimed to describe the potency of kitolod leaves for conjunctivitis. This is a narrative literature review using publications gathering from PubMed and Google Scholar published since 2013 with exclusion criteria were the animal studies. The keywords of COVID-19 pandemic, blue light, conjunctivitis, H. longiflora, traditional therapy were used. Boolean logic "AND" was used to find specific international scientific publications in PubMed. Forty selected publications were gathered, summarized and then narrated. The kitolod leaves contains bioactive substances i.e. flavonoids, alkaloids, and saponins which can inhibit S. aureus growth as the main cause of conjunctivitis. The mechanism of antibacterial of these bioactive substances through inhibition of nucleic acid synthesis, disruption of cytoplasmic membrane function, and inhibition of energy formation process. Kitolod leaves is potential to develop as traditional medicine for conjunctivitis. However, further studies are required to obtain the best standardized extract and to evaluate its clinical efficacy and safety.
Early drug-induced hepatotoxicity in newly diagnosed HIV-positive patients on ARV therapy: A retrospective follow-up study of liver function profiles Lukman Ade Chandra; Yanri Wijayanti Subronto; Jarir At Thobari
Indonesian Journal of Pharmacology and Therapy Vol 4 No 2 (2023)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.386 KB) | DOI: 10.22146/ijpther.7817

Abstract

Antiretroviral therapy (ART) is a primary therapeutic modality for managing individuals with Human Immunodeficiency Virus (HIV) infection, and its efficacy has been established. However, the safety profiles of ART need to be continually monitored, including early elevated liver function test (LFT) after antiretroviral (ARV) initiation. This study aimed to assess the incidence of abnormal LFT among HIV-positive patients receiving initial ARV and to identify factors associated with abnormal LFT. A retrospective cohort study without a control group summarised medical records from Dr Sardjito General Hospital, Yogyakarta between January 2014 and December 2021. The study subjects were adult HIV patients taking their first ARV and underwent follow-up visits for at least two weeks. Study outcomes were LFT levels, abnormal LFT, and factors associated with abnormal LFT during follow-up visits at 2 wk, 6 mo, and 12 mo. Univariate and multivariate analyses will be performed with a significance level of p<0.05. A total of 137 subjects with 203 visits were retrieved from medical records. The subjects' mean age was 33.4 years, predominantly male, younger, unmarried, in the early stage of HIV infection, and without comorbidities. The findings showed a significant increase in alanine transaminase (ALT) at all three follow-up visits: 2 wk (p=0.02), 6 mo (p=0.003), 12 mo (p=0.001) and an increase in aspartate aminotransferase (AST) after 6 mo (p=0.007) and 12 mo (p=0.04). Abnormal LFT levels (AST and/or ALT) were observed in 23.4% of patients after a normal baseline, with ALT increase being more common. Furthermore, homosexuality was identified as a significant independent factor associated with abnormal LFT (AOR=3.1; 95% CI 1.27-7.51; p=0.01). The findings indicate exceptionally elevated LFT levels and the occurrence of abnormal LFTs among HIV-positive patients initiating ARVs. The increase in abnormal LFTs was significantly associated with patients identifying as homosexual, where hepatitis co-infection may be a contributing factor. The limited study design and measured variables warrant further investigation.
Physical properties and stability of grapeseed oil (Vitis vinifera L.) skincare formula with gelling agent combination of Na-CMC-carbopol and HPMC-carbopol Abdul Karim Zulkarnain; Chairunnisa Nurul Ichsani; Candriya Lael Judiantoro
Indonesian Journal of Pharmacology and Therapy Vol 4 No 2 (2023)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.352 KB) | DOI: 10.22146/ijpther.8279

Abstract

Skincare products made from natural ingredients have become the choice of many people. Grapeseed oil contains ingredients that act as a moisturizer. Na-CMC-carbopol and HPMC-carbopol are gelling agents that are widely used in preparations due to their compatibility with various materials. All three are combined to cover their respective deficiencies. This study aimed to evaluate the effect of the combination of Na-CMC-carbopol and HPMC-carbopol on the physical properties and stability of grapeseed oil gel and to determine the optimum formula. The research method was carried out by optimizing the levels of Na-CMC (2-2.5%), HPMC (2-20%), and carbopol (0.5-1%) with the Simplex Lattice Design method. Eight runs of the resulting formula were gelled and tested for their physical properties to determine the optimum formula. The optimum formula obtained was verified with statistical analysis and tested for physical stability. The stability data were analyzed statistically, 95% confidence level. The optimum formula for NaCMC-carbopol was at a concentration of 2.220% Na-CMC and 0.780% carbopol, pH 6.246 ± 0.057, spreadability 12.96 ± 0.48 cm2, adhesion 6.33 ± 0.48 sec, viscosity 166.00 ± 4.88 dPas. HPMC-carbopol at both concentrations of 1% had a pH of 4.973 ± 0.172, a viscosity of 175.20 ± 5.44 dPas, a spreadability of 18.12 ± 1.61 cm2, and an adhesion of 6.94 ± 1.68 sec. All preparations were not significantly different between predictions and experiments. The optimum gel formula had good physical properties and was stable during 3 cycles of cycling stability test.
The role of family caregivers in medication adherence of elderly in Asian setting: a scoping review Chairun Wiedyaningsih; Niken Nur Widyakusuma; Sri Suryawati
Indonesian Journal of Pharmacology and Therapy Vol 4 No 2 (2023)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.476 KB) | DOI: 10.22146/ijpther.8379

Abstract

Family caregivers for elderly play a very important role in implementing drug adherence, especially in Asian countries. Various determinants of medication adherence included caregivers as family support. Although the relationship between family support is not always significant, understanding the factors of family caregivers on medication adherence is important, especially when improving adherence in Asian countries. The following scoping review was conducted to provide an overview of caregivers, and its relationship to medication adherence in Asian settings. PRISMA-ScR guideline and checklist was used for the search process and to guide reporting. Review selection and characterization were performed by reviewers independently. In total, 22 papers were included in the review, published from 2011 to 2021. The studies varied in terms of purpose, methodology, and detail of reporting. Family caregiver is an important determinant of medication adherence, especially for areas where extended family culture is still strong, such as in Asia. Understanding the local culture, aspects of family burden and economic, as well as the role of the health profession, especially pharmacists in health services are needed to improve adherence. Therefore, further research with quality methods is needed.

Page 1 of 1 | Total Record : 5

 1 

Filter by Year

2023 2023


Reset
Filter By Issues
All Issue Vol 4 No 2 (2023) Vol 4 No 1 (2023) Vol 3 No 3 (2022) Vol 3 No 2 (2022) Vol 3 No 1 (2022) Vol 2 No 3 (2021): Special Issue: COVID-19 Vol 2 No 3 (2021) Vol 2 No 2 (2021) Vol 2 No 1 (2021) Vol 1 No 2 (2020) Vol 1 No 1 (2020) More Issue