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Muhamad Thohar Arifin MD. PhD. Faculty of Medicine, Diponegoro University Jl. Prof. Soedarto, Tembalang, Kec. Tembalang, Kota Semarang, Jawa Tengah 50275 Email: dimjoffice@gmail.com
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Diponegoro International Medical Journal (DIMJ)
Published by Universitas Diponegoro
ISSN : Without     EISSN : 27455815     DOI : https://doi.org/10.14710/dimj
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience
Diponegoro International Medical Journal (DIMJ) ISSN Number: 2745-5815 welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world. DIMJ is an international, peer review, electronic, and open access journal. DIMJ is seeking an original and high-quality manuscript. Areas of interest in all aspects of medical and physiology include but are not limited to the following topics: Modelling of diagnose and cure of human diseases The scientific underpinning of medicine and pathophysiology Biochemistry and biology molecular solution Decision support systems Biomedicine Any experimental design and statistical analysis The application of new analytical and study methods (including biomolecular studies)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol 3, No 1 (2022): July 2022" : 6 Documents clear
CORELLATION OF STRESS LEVEL DURING COVID-19 PANDEMIC AND THE INSIDENCE OF ACNE ON STUDENTS: STUDY ON UNDERGRADUATE STUDENTS OF THE FACULTY OF MEDICINE OF DIPONEGORO UNIVERSITY Fanti Saktini
Diponegoro International Medical Journal Vol 3, No 1 (2022): July 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i1.14960

Abstract

Background: Acne vulgaris (Acne) is the most common inflammatory disease of skin among adolescents and young adults (85%). Corona Virus Disease (COVID-19) pandemic had enforced lockdowns and thus inevitably converted the conventional schooling system to online learning. These changes raised psychological burden among students, including medical students. Psychological distress might influence the emergence of acne or added its severity.Aim: To know the correlation between stress level during pandemic and the incidence of acne vulgaris among students in Faculty of Medicine Diponegoro University.Method: This study used cross-sectional design, incorporating 97 undergraduate students (batch of 2018-2020) of Faculty of Medicine Diponegoro University, whom suffered from acne, had consented to participate consecutively. Data consisted of subjects’ characteristic and Depression and Anxiety Stress Scale 21 questionnaire. These data were analysed using Chi-square test.Results: Most of the subjects suffered from acne (60.8%), whereas the level of stress varied from normal (61.9%), mild (25.8%), moderate (9,3%), to severe (3.1%). There was no significant relationship between stress level during COVID-19 pandemic and the incidence of acne vulgaris among subjects. (p=0,805).Conclusion: There was no significant relationship between stress level during COVID-19 pandemic and the incidence of acne vulgaris among medical students.
Association of Type of Antiepileptic Drugs and Serum Vitamin D Levels among People with Epilepsy Adelia Putri Maharani; Hasna Syariva; Dwi Ngestiningsih; Arinta Puspita Wati; Santoso Jaeri
Diponegoro International Medical Journal Vol 3, No 1 (2022): July 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i1.14540

Abstract

Background: Epilepsy is a brain disease characterized by repeated unprovoked seizures at least two times with an interval of more than 24 hours between the first seizure and subsequent seizures. Valproic acid is an anti-seizure drug. Long-term use of valproic acid may be associated with metabolic disorders such as weight gain, and lipid profile changes, including vitamin D levels. Objectives: To determine the association of type of antiepileptic drugs and serum vitamin D levels among people with epilepsy.Methods: A cross-sectional study among 24 people with epilepsy was obtained from the outpatient clinic Diponegoro National Hospital Semarang. The subjects were then classified based on the type of antiepileptic drugs into two groups. The first group was subjects who used valproic acid (n=15) and the second group was subjects who used phenytoin (n=9). The demographic and clinical data were collected, then the measurement of vitamin D levels was performed using ELISA. The two independent samples T-test were performed to determine the differences of serum vitamin D levels among people with epilepsy.Results: The mean of serum vitamin D levels among 24 subjects were 17,32 + 6,37 ng/mL, and the mean of serum vitamin D levels based on the type of antiepileptic drugs were 16,92 + 4.27 ng/mL for the first group and 18 + 9.16 ng/mL for the second group. Furthermore that there was no significant difference in the serum vitamin D levels in both groups (p=0,697).Conclusion: There is no different effect of valproic acid and phenytoin on the serum vitamin D levels among people with epilepsy.
Wound Healing Response to Full-Thickness Skin Defect Sprague Dawley Rats Given Ozonated Black Cumin Oil Viewing from The Profile of Neutrophil and Macrophage Count Igor Rizkia Syahputra
Diponegoro International Medical Journal Vol 3, No 1 (2022): July 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i1.14955

Abstract

The incidence of wounds keeps increasing and inadequate treatment can cause the wound to become infected. Ozone has antibacterial properties and can help activate pro-inflammatory agents in the wound healing process; one of the methods is oil ozonation, for example with black cumin oil. Topical administration of black cumin plays a role in wound healing because of its antibacterial and antifungal properties, and plays a role in increasing the epitalization process. To determine the effectiveness of applying ozonated black cumin oil (Nigella sativa) on the healing process of full-thickness skin defects in Sprague Dawley rats, in terms of the number of macrophage and neutrophil cells. This research was an experimental study with a post-test only control group design method. Total sample of 48 Sprague Dawley rats was divided into 6 groups. The first group was given gentamicin ointment, the second group was given 0.9% normal saline, the third to the fifth group was given ozone black with doses of ozone respectively, namely 1400 mg/ml, 1800 mg/ml and 2200 mg/ml. Incision for taking the tissue samples was held on the 3rd and 7th day according to the treatment group. The tissue samples were subjected to histopathological examination with HE staining. A significant decrease in neutrophil levels occurred at the dose of 1,400mg/ml ozonated black cumin oil on day 7 (p=<0.001), dose of 1,800 mg/ml on day 3 (p=0.021) and day 7 (p=<0.001), doses of 2,200mg/ml at day 3 (p=0.020) and day 7 (p=<0.001) compared with a positive control group (given gentamicin). A significant decrease in macrophage levels occurred at a dose of 1,400mg/ml on day 3 (p=0.037) and 7 (p=0.019), a dose of 1,800 mg/ml on day 3 (p <0.001) and 7 (p=0.020), dose 2,200mg/ml on day 3 (p=<0.001) and day 7 (p=0.020).
The Relationship Between Obstructive Sleep Apnea And Levels Of Depression And Anxiety In Young Adults Kanti Yunika
Diponegoro International Medical Journal Vol 3, No 1 (2022): July 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i1.14961

Abstract

ABSTRACTBackground: Obstructive sleep apnea (OSA) is one of the most common and serious sleep disorders that can cause various neurocognitive disorders such as depression and anxiety. OSA can occur in young adults, whom are in an important developmental age in human life. The relationship between OSA and levels of depression and anxiety has never been studied in young adults, especially college students. Early identification and treatment is expected to have an impact on better quality of life and productivity..Aim: To determine the relationship of OSA with levels of depression and anxiety in young adultsMethods: An observational study with a cross sectional design. Data were obtained from Berlin questionnaire, Zung Self-Rating Depression Scale and Zung Self-Rating Anxiety Scale which were filled out in September-November 2021. Bivariate analysis of OSA's relationship with depression and OSA with anxiety was tested using chi-square test. Multivariate logistic regression analysis was performed to test for confounding variables.Results:  There was a significant relationship between OSA and depression (p=0,000, OR 4.07) and OSA and anxiety (p=0,000, OR 4.5) in young adults. Logistic regression analysis showed that gender was a confounding variable of anxiety (p=0.044) in young adults.Conclusion: There is a significant relationship between OSA and levels of depression and anxiety in young adults. Young adults who have OSA are 4.07 times more likely to be depressed than young adults who don’t have OSA. Young adults who have OSA are 4.5 times more likely to experience anxiety than young adults who don’t have OSA. There is a significant relationship between OSA and the level of anxiety controlled by the confounding variable, namely gender.
Histological and Clinical Stage Profiles of Young-aged Breast Carcinoma Alda Vania Sugiarto Hadiyanto; Ika Pawitra Miranti; Yan Wisnu Prajoko; Hermawan Istiadi
Diponegoro International Medical Journal Vol 3, No 1 (2022): July 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i1.13944

Abstract

Background: Breast cancer is the most common type of malignancy in women. Many studies report that the characteristics and prognosis of young-aged breast carcinoma are worse than in old age. Data on young-aged breast carcinoma in Indonesia is relatively lacking and always needs updates.Objective: To determine the incidence and distribution based on histological profiles and clinical stage, as well as the association between molecular subtype with grade and clinical stage of young-aged breast carcinoma (<40 years old) at Dr. Kariadi General Hospital Center in 2018-2020.Methods: This research was an observational descriptive study using medical records of young-aged breast carcinoma patients which were recorded at Dr. Kariadi General Hospital Center from 1st January 2018 until 31st December 2020. The data were processed with Microsoft Excel and SPSS.Results: The results showed that there were 110 patients consisting of 25 people in 2018, 37 people in 2019, and 48 people in 2020. The most common histological and clinical stage was IBC-NST with 75 people (68,18%), Luminal B with 53 people (48,18%). grade II with 71 people (64,65%), and stage IV with 45 people (40,09%). There is a significant association between molecular subtype and grade (p=0.003). There is no significant association between molecular subtype and clinical stage (p=0.704).Conclusion: The incidence of young-aged breast carcinoma at Dr. Kariadi General Hospital Center in 2018-2020 was increasing every year. The most common histological profiles and clinical stage during that period were IBC-NST, Luminal B, grade II, and stage IV. There is a significant association between molecular subtype and grade.Keywords: Breast carcinoma, clinical stage, grade, histological type, molecular subtype, young age
Correlation between Hematologic Parameters and Asymptomatic Bacteriuria in the Full-Term Pregnant Patients in Dr. Kariadi Hospital, Semarang, Indonesia Muhamad Sukri
Diponegoro International Medical Journal Vol 3, No 1 (2022): July 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i1.14019

Abstract

Objective: We investigated the role of hematologic parameter such as hemoglobin, white blood  cells, platelet, hemoglobin platelet ratio (HPR), hemoglobin white blood cells ratio (HWR) in  full-term pregnant patients and correlate the result with their urine culture following delivery.  Methods: Between 2019-2020, a total number of 95 pregnant patients were retrospectively  evaluated at the maternal ward.Results: The average age of the subjects was 29.15 (SD ± 5.95), median of parity of 2 (range 1- 4) and mean of gestational age was 37.5 (SD ± 1.67). There is no difference between groups on  the surgery types and comorbidities condition. Among the patients, 14 urine cultures produced  growth of 105 CFU/ml bacteria. Pearson’s correlation test showed that leukocyte inversely  correlated with bacteriuria, meanwhile hemoglobin white blood cell ratio (HWR) is positively  correlated with urinary culture result. In the diagnostic performance, HWR had AUC of 0.765  with sensitivity and specificity of 78.6% and 64.2% respectively at the cut off of 11.92.Conclusions: Prediction of asymptomatic bacteriuria in pregnant patient by simple calculation of  HWR might be helpful in significantly reducing workload and costs of urine culture. It is a great  advantage that the parameters we use in our work are easily accessible and can be performed in  emergency conditions.

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