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Muhamad Thohar Arifin MD. PhD. Faculty of Medicine, Diponegoro University Jl. Prof. Soedarto, Tembalang, Kec. Tembalang, Kota Semarang, Jawa Tengah 50275 Email: dimjoffice@gmail.com
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Diponegoro International Medical Journal (DIMJ)
Published by Universitas Diponegoro
ISSN : Without     EISSN : 27455815     DOI : https://doi.org/10.14710/dimj
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience
Diponegoro International Medical Journal (DIMJ) ISSN Number: 2745-5815 welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world. DIMJ is an international, peer review, electronic, and open access journal. DIMJ is seeking an original and high-quality manuscript. Areas of interest in all aspects of medical and physiology include but are not limited to the following topics: Modelling of diagnose and cure of human diseases The scientific underpinning of medicine and pathophysiology Biochemistry and biology molecular solution Decision support systems Biomedicine Any experimental design and statistical analysis The application of new analytical and study methods (including biomolecular studies)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol 3, No 2 (2022): December 2022" : 6 Documents clear
Factors Associated With Recurrence Of Epithelial Ovarian Cancer In RSUP Dr. Kariadi Semarang Isabela Marsialina Kurube; Ediwibowo Ambari; Teuku Mirza Iskandar; Hary Tjahjanto; Julian Dewantiningrum; Arufiadi Anityo Mochtar; Yuli Trisetiyono
Diponegoro International Medical Journal Vol 3, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i2.15448

Abstract

Introductions: Epithelial ovarian cancer accounts for 90% of all ovarian malignancies. More than 70% of patients will experience a relapse even after receiving operative therapy and chemotherapy. There are several prognostic factors that influence the recurrence of ovarian cancer. In Indonesia, especially at Dr. Kariadi Hospital, Semarang, the data as mentioned above is still very limited.objective: Knowing the disease-free survival rate, optimizing surgery and factors related to the incidence of recurrence in epithelial ovarian cancer patients at Dr. Kariadi Hospital SemarangMethods: This study is a retrospective cohort study with survival analysis. Data were collected through medical records, with the study population are patients with a diagnosis of epithelial ovarian cancer who were treated at Dr. Kariadi Hospital Semarang in period January 2018-December 2019. Furthermore, patients who had been remission were observed for signs of disease recurrence for 2 years period.Results: There were 361 patients with epithelial ovarian cancer who underwent primary treatment at Dr. Kariadi Hospital, Semarang in  2018-2019. Furthermore, there were observations of recurrence in 148 patients who achieved remission. Of these 76 patients (51.4%) experienced recurrence, while 72 patients not relapse. From 148 epithelial ovarian cancer patients who underwent cytoreduction surgery at Dr. Kariadi Hospital, Semarang, 113 patients (76.4%) achieved optimal operation with a residu less than 2 cm, while 35 patients (23.6%) were not optimal with a residu more than 2 cm. FIGO stage (HR 2.44) and tumor residu (HR 2.15) were shown to be significant factors associated with the recurrence of epithelial ovarian cancer.Conclusion: Overall disease-free survival in epithelial ovarian cancer at Dr. Kariadi Semarang were 74.8% (6 months), 57.1% (1 year), 42.5% (18 months), and 37.4% (2 years). Tumor residual factors and FIGO stage were shown to be significant prognostic factors influencing the recurrence of epithelial ovarian cancer. 
RELATIONSHIP BETWEEN ANXIETY LEVEL IN PANDEMIC AND MEDICAL ADHERENCE IN HYPERTENSIVE ELDERLY Haidar Yusuf Affandy
Diponegoro International Medical Journal Vol 3, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i2.14587

Abstract

Abstract Background: Hypertension in Indonesia increases with age. People with hypertension need continuous treatments according to doctor’s recommendation, if not it will cause serious complications. Medication non-adherence of hypertensive elderly caused by many factor, one of them is psychological factor. Health care visits decrease during pandemic because of the COVID-19 transmission anxiety.Objective: To find out the correlation between anxiety level and medical adherence of hypertensive elderly in Kangkung Village, Mranggen during the COVID-19 pandemic.Methods: Cross-sectional study was conducted with Proportional Random Sampling approach on 96 hypertensive elderly in Kangkung, Mranggen, Demak Regency. The study was conducted by interview using Zung Self-rating Anxiety Scale and Morisky Medical Adherence Questionnaire. Data analysis using Rank Spearman correlation test. This study had got Ethical Clearance from Health Research Ethics Committee of Faculty of Medicine of Diponegoro University.Results: There was a correlation between anxiety level and medical adherence, p value = 0,005 (p < 0,01) and the higher anxiety level will decrease the medical adherence (ρ = – 0,287).Conclusion: Anxiety that were experienced by the elderly has been shown to be related to medical adherence during the COVID-19 pandemic.
The Association between Obstructive Sleep Apnea and Glycated Haemoglobin A1c (Hba1c) Level in Diabetes Mellitus Type II Patient Anna Mailasari Kusuma Dewi; Peny Handayani; Devi Elvina Rachma; Edward Kurnia Setiawan Limijadi
Diponegoro International Medical Journal Vol 3, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i2.15191

Abstract

Abstract Background: Obstructive sleep apnea (OSA) is a chronic condition characterized by repetitive episodes of upper airway collapse, apnea, and arousal during sleep. OSA and type 2 diabetes mellitus (T2DM) are common comorbid conditions. Haemoglobin A1c (HbA1c) is an approximation of an individual’s average blood glucose level for the prior two to three months, and therefore is considered to be a major index for monitoring glycaemic control in diabetic patientsObjective: This study aimed to examine the association between OSA and HbA1c levels in T2DM patients.Methods: This was a cross-sectional study. The study assesses the association between OSA and HbA1c levels in 75 T2DM patients. OSA in the patient was asses with Epworth Sleepiness Scale (ESS) questionnaire. HbA1c values were obtained from the patient’s records. Data presented in mean ± SD, max, and min. Correlations analyses using Pearson correlation coefficient with p < 0.05 were considered statistically significant.Results: A total of 75 T2DM has a mean BMI were 25.26 ± 48.31 kg/m2 with mean HbA1c levels of about 7.1 ± 0.19%. The mean ESS score was 5 ± 0.429. The very weak correlation between OSA and BMI was statistically significant, r = 0.213; p = 0.047. Meanwhile, a very weak correlation between OSA and HbA1c levels was not statistically significant, r = 0.137; p = 0.242Conclusion: Among adults with T2DM, the correlation between OSA with HbA1c was not statistically significant
Comparison of Saline Infusion Sonohisterography (SIS) and Histeroscopy Examination in Abnormal Uterine Bleeding Apdhika Kristian Trisanto; Hary Tjahjanto
Diponegoro International Medical Journal Vol 3, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i2.15412

Abstract

Introduction: Abnormal uterine bleeding (AUB) is bleeding from the uterus that is longer than usual or that occurs at an irregular time, affecting 20% of the adolescent age group, and 50% of women aged 40-50 years in Indonesia. The causes of AUB are pregnancy, anovulatory dysfunction, uterine leiomyoma, endometrial polyps, endometrial hyperplasia, or endometrial carcinoma. This study aims to compare the accuracy of Saline Infusion Sonohysterography (SIS), hysteroscopy and endometrial histopathology in determining pathological abnormalities in women with AUB.Material and Method: This cross sectional diagnostic study was conducted at General Hospital dr. Kariadi Semarang and its network hospitals in June 2020. Samples were determined by consecutive sampling, including married women, not pregnant, had no genital infection and did not present with any malignancy. Histopathological examination of the endometrium is the gold standard for AUB diagnosis. Research data were obtained from secondary data from patient's medical records including demographic characteristics, clinical history, pregnancy history, SIS examination data, hysteroscopy and endometrial histopathology.Result: There were 51 subjects with a mean age of 31.67 ± 5.21 years. The most common complaints were intermenstrual bleeding (37.3%), followed by irregular menstrual bleeding (21.6%), heavy menstrual bleeding (13.7%), and amenorrhea (5.9%). Sensitivity value of SIS examination ranged from 81.5-100% and specificity ranged from 30.77-100%. Hysteroscopy has a sensitivity value range of 87.5-98% and a specificity value of 62.5-100%.Conclusion: SIS examination could be an alternative for endometrial structural abnormalities diagnosis in AUB if hysteroscopy is unavailable.
The Effect of Folic Acid Adjuvant on Cognitive Function on Patients with Chronic Schizophrenia Yulia Ratna Sofa; Natalia Dewi Wardani; Linda Kartika sari; Titis Hadiati; Muflihatunnaimah Muflihatunnaimah
Diponegoro International Medical Journal Vol 3, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i2.15219

Abstract

ABSTRACT   Background: Schizophrenia is a severe mental disorder that associated with daily life and social function deterioration and could be accompanied with cognitive deficits. Meanwhile, hyperhomocysteinemia (HHcy) is the increasing homocysteine (Hcy) level which might be the one of biological factor in schizophrenia. In recent study with healthy subjects, it was known that there was a correlation between total Hcy level and cognitive function. Folic acid is part of water-soluble vitamin B and expected to have important role in oxidative stress by preventing hyperhomocysteinemia.Objective: This study aimed to elaborate the effect of folic acid adjuvant to improve cognitive function in chronic schizophrenia patients.Methods: This was a double-blinded randomized controlled trial with pre and post-test clinical trial design. This study included 32 patients in control group and 32 patients in treatment group. MOCA-INA score was examined in all subjects on the first day. Then, all subjects were given standard antipsychotic treatment plus folic acid adjuvant / placebo during 3 week of hospitalized treatment and 1 week of outpatient treatment. When the 4-week treatment finished, the subjects were followed by MOCA-INA post-test.Results: In this study, we had the significant difference of pre and post-test MOCA-INA score in the control group (p<0.001), significant difference of pre and post-test MOCA-INA score in the treatment group (p<0.001), and significant difference of post-test MOCA-INA score between the control and treatment group (p<0.001).Conclusion: Folic acid adjuvants significantly improved cognitive function in chronic schizophrenic patients.  
A Comparison of Wound Healing Score between Chromic Catgut and Polyglycolic Acid Perineal Suturing at Seven Days Postpartum: A Single Blind Randomized Controlled Trial Syaiful Alam
Diponegoro International Medical Journal Vol 3, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i2.15429

Abstract

Background: Perineal Injury is a frequent vaginal delivery complication that can result in dyspareunia, urine and fecal incontinence, granulomas, and discomfort, which can contribute to long-term morbidity. The choice of suture material determines the outcome in perineal injury. This study aims to compare the wound healing scores between chromic catgut and polyglycolic acid perineal suturing at seven days postpartumMethods: Randomized control trial study conducted at 3 hospitals in Indonesia. The patient met our criteria was randomly group into Chromic Catgut as a control and Polyglycolic Acid as a treatment group. After 7 days of perineal suturing, the wound healing was assessed with REEDA (redness, edema, ecchymosis, discharge, approximation) score by the chosen operator.Results:  No significant difference in each indicator of the REEDA score (p>0.05). Most of the indicators are each dominated by a score of 0. The maximum score for redness is 2, the score for edema is 1, the score for ecchymosis and discharge is 0, the approximation score is 1, and the total score is 4. On hematological examination, polyglycolic acid showed lower hemoglobin levels and higher leukocyte levels compared to chromic catgut (p=0.025 and 0.005, respectively).Conclusion: There was no difference in wound healing score between Chromic Catgut and Polyglycolic Acid Perineal Suturing at Seven Days Postpartum.

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