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Bayu Brahma
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INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 5 Documents
 1 
Search results for , issue "Vol 13, No 2 (2019): June" : 5 Documents clear
Expression of Ki67 in Precancerous Squamous Cell Skin Lesion of Mice Induced by DMBA Siti Nurkasanah; Aida S D Hoemardani; Evlina Suzanna Sinuraya
Indonesian Journal of Cancer Vol 13, No 2 (2019): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1179.783 KB) | DOI: 10.33371/ijoc.v13i2.638

Abstract

Background: Squamous cell carcinoma (SCC) is an invasive skin cancer that is found in the human skin. SCC growth from the precancerous lesion is known as a wart or papilloma. Ki67 is a protein expressed by cells during proliferation. Cells with higher Ki67 expression showed abnormal regulation of apoptosis. 5-FU is an antimetabolite compound that works as a DNA/RNA pyrimidine antagonist molecule that can induce cell apoptosis. The main objective of this research is to evaluate the inhibition proliferation of precancerous squamous cell in skin lesion induced by DMBA/croton oil treated by using 5-FU cream topically compared to 5% imiquimod cream. Methods: This research assesses three different concentrations of 5-FU cream namely 1%, 2%, and 5% topically on 24 wild type mice divided into 6 groups of 4 each including positive control (with carcinogenesis but without treatment), negative control (without treatment ; normal), carcinogenesis with treatment 5-FU cream (1%, 2%, and 5%) or 5% imiquimod cream. The expression of Ki67 was analyzed using immunohistochemistry. Statistical analysis was performed by one-way ANOVA using SPSS version 23. Results: Based on this research, 5-FU cream treatment during 4 weeks (week 10-week 14) showed the decrease of cumulative number of papilloma (p<0.05) and immunohistochemistry analysis resulted in the lowest Ki67 expression in 5-FU 2% and 5% groups compared to 5% imiquimod cream (p<0.05). Conclusions: 5-FU cream treatment during 4 weeks showed a decrease of papilloma and Ki67 expression in 5-FU cream 2% and
Investigation of Genital System Cancers Prevalence in Isfahan, Iran Zahra Tolou-Ghamari
Indonesian Journal of Cancer Vol 13, No 2 (2019): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (775.748 KB) | DOI: 10.33371/ijoc.v13i2.631

Abstract

Background: Previous publication reported a significant disparity of genital cancer incidence between genders. The aim of this study is to investigate period prevalence (PP) and incidence (Irs) of genital cancer in Isfahan/Iran. Methods: Information equivalent to those collected by the USA Surveillance, Epidemiology, and End Results (SEER) program was obtained from the Isfahan Cancer Registry. Period prevalence (PP) was calculated per 100.000 persons. The cancer sites studied were defined according to the International Classification of Diseases (ICD-O; Third Edition) and recorded by topography code. Results: Between the years 2011 to 2015, among all registered cases (3024 cases), 60% applied to the male genital system. The mean (SD) age at diagnosis was higher for men 69.4 (14.7) than women 57.8 (15) (t-test; P<0.006). The calculated PP was significantly (Chi-squared test; P<0.001) higher in males (71.5) than females (49.6) per 100.000 in Isfahan Province. Conclusions: The PP for ovarian cancer in female and prostate cancer in male was higher than for other genital tumors. To facilitate early diagnosis for better management, we recommend that health-care plans for Isfahan Province/Iran place a greater focus on pharmacotherapy and environmental factors in cancer control.
The Difference of Hypoxia Inducible Factor 2α mRNA Expression in High-Grade and Low-Grade Glioma Tissue Bagus Ramasha Amangku; Syaiful Ichwan; Septelia Inawati Wanandi; Novi Silvia Hardiany
Indonesian Journal of Cancer Vol 13, No 2 (2019): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (967.349 KB) | DOI: 10.33371/ijoc.v13i2.633

Abstract

Background: HIF-2α is a transcription factor in hypoxic condition, and high expression levels of it correlate with the concepts of metastasis, therapy opposition and reduced quality of prognosis in various forms of cancerous growth. Due to the exceedingly infiltrative ability of brain glioma cells, gliomas cannot be completely deteriorated with surgery and the relapse rate is high. This study goal to identify the relative expression of HIF-2α gene in the direction of glioma malignancy and its classification. Methods: Specimens used in this research comprise of 20 glioma samples obtained from glioma patients in Cipto Mangunkusumo Hospital. Relative expression of HIF-2α was measured by utilizing quantitative Real Time-Polymerase Chain Reaction (RT-PCR). Cycle threshold (CT) values were achieved correlated with the amplified DNA, and then the relative expression was attained by using Livak method of calculation. Results: The results produced a greater average of relative expression of HIF-2α in the grade III and IV types (18.64; n=7) rather than in the lower grades (5.68; n=13). However, the data is statistically inconsequential. Conclusions: High-grade glioma tends to express HIF-2α mRNA higher compared to the lower grade. Therefore, it is possible to use HIF-2α as a prognostic marker for glioma- diagnosed patients, although additional experiments need to be performed to strengthen these facts.
Effect of Initial Cytoreductive Nephrectomy with Target Therapy versus Target Therapy Alone in Metastatic Renal Cell Carcinoma: A Single Institutional Study Rasha Mohamed Abdel Latif; Kamel Farag Selim
Indonesian Journal of Cancer Vol 13, No 2 (2019): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1039.816 KB) | DOI: 10.33371/ijoc.v13i2.635

Abstract

Background: The metastatic renal cell carcinoma (mRCC) patients treated with upfront cytoreductive nephrectomy (CN) combined with immunotherapy results in overall survival (OS) improvement. It is unclear whether mRCC patients treated with target therapy will also benefit from CN. The aim of the study was to identify the benefit of upfront CN followed by targeted therapy (TTs) versus TTs alone on OS of patients with mRCC, and to evaluate pre-operative variables for selection of patients who would benefit from CN, and also the response rate (RR) and the progression-free survival (PFS). Methods: A retrospective study was performed in our Department on patients diagnosed with mRCC within the period of January 2013 to April 2018. Data that were collected included patients and tumor characteristics. Patients were divided into two groups: 1) received upfront CN followed by TTs, and the 2) one treated with TTs alone. Survival analysis was performed using Kaplan-Meier method, univariate analysis with log-rank test was used to estimate predictors of survival in the CN group, and Cox regression was used for multivariate analysis. Results: The median OS of all patients was 14 months, and was 19 and 10.5 months in CN and non-CN respectively with significant difference (P˂0.001). Lower hemoglobin level (P=0.012), high neutrophil count (P˂0.001), low albumin level (P=0.006), number of metastatic sites ≥3 (P˂0.001), and patients with number of risk factors ≥3 (P˂0.001) have a negative impact on OS in CN group. Conclusions: Upfront CN before TTs in mRCC carries better survival than TTs alone. Five pre-operative variables (i.e. hemoglobin level, neutrophil count, albumin level, number of metastatic sites, and number of risk factors) were identified as suitable for selection of patients who will benefit from CN.
Survival Analysis in Pediatric Osteosarcoma Mururul Aisyi; Ayu Hutami Syarif; Nur Asih Anggraeni; Adhitya Bayu Perdana; Hutomo Rezky; Agus Kosasih; Achmad Basuki
Indonesian Journal of Cancer Vol 13, No 2 (2019): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (788.222 KB) | DOI: 10.33371/ijoc.v13i2.622

Abstract

Background: Osteosarcoma is the most common bone malignancy in childhood and adolescence. Despite significant advances in diagnostic and therapeutic modalities, osteosarcoma has generally poor prognosis. Several studies highlighted the prognostic significance of demographic and clinical parameters in the pediatric population. Controversy exists about which obvious factors of mortality in some institutions. Meanwhile, little is known about the overall survival (OS) of pediatric osteosarcoma in Dharmais Cancer Hospital.The aim of this study is to estimate the OS in pediatric osteosarcoma.Methods: This retrospective cohort study enrolled 41 children with osteosarcoma during the period of January 2010-September 2017. Patients were selected using inclusion and exclusion criteria. Overall survival (OS) and patient variables were plotted using Kaplan-Meier.Results: Our result showed that all patients admitted to our hospital in advanced stages (IIB and III). Their median OS was 23 months (12.3-33.7 months) with the survival probability was 29.4%.Conclusions: Median OS of pediatric osteosarcoma in our institution was 23 months and the survival probability was 29.4%. It can be used as evidence showing lack of cancer awareness and early detection in our country.

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