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Bayu Brahma
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INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 405 Documents
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Phosphorylated Ataxia Telangiectasia Mutated (pATM) Enzyme-Linked Immunosorbent Assay (ELISA) for Predicting Radiation Induces Normal Tissue Toxicity in Radiotherapy Patients: A Systematic Review Sofiati Purnami; Viria Agesti Suvifan; Dwi Ramadhani; Yanti Lusiyanti; Darlina Darlina; Nastiti Rahajeng; Mukh Syaifudin; Dwi Ari Pujianto; Retno Widowati
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.971

Abstract

Background: An adverse normal tissue response, such as normal tissue toxicity (NTT), is present in radiotherapy (RT) patients and can limit the effectiveness of the RT treatment. Identifying patients with adverse tissue responses before RT had clinical benefits and individual radiosensitivity (IRS) is considered an important factor in NTT incidences. Therefore, this systematic study aimed to determine the possibility of using phosphorylated Ataxia Telangiectasia Mutated (pATM) Enzyme-Linked Immunosorbent Assay (ELISA) to predict NTT in RT patients.Methods: A comprehensive data search was conducted in three electronic databases, namely PUBMED CENTRAL, ScienceDirect, and SCOPUS. The quality of relevant publications was independently evaluated using the PICO (participants, intervention/exposure, comparison, and outcome) approach.Results: : A total of 47 articles were retrieved, 41 of which were assessed based on the titles and abstracts. Furthermore, 39 articles were excluded, and 2 were included in this study.Conclusions: The phosphorylated ATM ELISA on lymphocytes showed promising results for IRS prediction in RT patients. However, these assumptions should be validated on a larger RT patient cohort.
Proactive versus Reactive Nutrition Therapy in Head and Neck Cancer Patients Treated with Chemoradiotherapy: A Case Series Dian Araminta Ramadhania; Diyah Eka Andayani; Wina Sinaga
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.972

Abstract

Introduction: Malnutrition is frequently found in head and neck cancer (HNC) patients subjected to chemoradiotherapy. Furthermore, the condition can hinder therapy and increase patient mortality. Nutrition therapy may be given proactively and reactively before and during chemoradiotherapy, as a response to nutritional status deterioration. Early or proactive nutrition therapy is considered superior in minimizing weight loss and interruption days during chemoradiotherapy. Therefore, this study aims to explore the clinical impact of proactive and reactive nutrition therapies.Case Presentation: A total of 4 HNC patients were subjected to chemoradiotherapy and received nutrition therapy at different points. Approximately 2 patients received proactive nutrition therapy, while the other 2 underwent reactive nutrition after cancer treatment. Increased intake was achieved through administering oral nutrition supplements and supporting a nasogastric tube. Patients who received proactive nutrition therapy experienced less weight loss compared to reactive therapy. Delayed initiation of nutrition therapy resulted in a more pronounced weight loss. Therefore, it was crucial to maintain energy intake in line with established recommendations to effectively uphold the nutritional status of cancer patients.Conclusions: Proactive nutrition therapy should be provided to HNC patients before the commencement of cancer therapy.
The Role of Liquid Biopsy for Detecting Epidermal Growth Factor Receptor (EGFR) Mutations in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) – A Preliminary Study in Indonesian Population Agus Susanto Kosasih; Arif Riswahyudi Hanafi; Ninik Sukartini; Mariska Pangaribuan; Muhammad Alfin Hanif; Willy Pandu Ariawan; Sri Agustini Kurniawati; Dian Cahyanti; Kartika Anastasia Kosasih; Alyssa Diandra; Markus Yovian; Lyana Setiawan
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.1061

Abstract

Background: The development of new biomarker-targeted therapies is associated with the improvements in overall survival of advanced non-small cell lung cancer (NSCLC) sufferers. However, tissue biopsy as the gold standard to determine tumor molecular status is not always feasible in advanced diseases. Liquid biopsy, a minimally invasive technique to obtain cytological and molecular assessment from patients allows real-time monitoring of tumors and identification of resistant mechanisms. Therefore, this preliminary study aimed to compare the molecular profile of advanced NSCLC from liquid and tissue biopsy.Methods:  This cross-sectional study was conducted on patients with NSCLC undergoing diagnostic procedures at Dharmais National Cancer Center Hospital from January 2018 to December 2021. Tissue biopsy to check epidermal growth factor receptor (EGFR) mutations was performed on formalin-fixed paraffin-embedded (FFPE) tissue blocks. Analysis of mutations involved using a home-brew polymerase chain reaction (PCR) based on a high-resolution melting technique. Meanwhile, the liquid biopsy was performed using blood samples, and sequencing for circulating tumor DNA (ctDNA) was carried out with NGS.Results: : The results showed that among the 22 subjects enrolled in the study, tissue biopsy identified wild-type EGFR in 18 (81.8%), exon 19 mutations in 3, and exon 21 mutations (L861Q and L858R) in 3. Liquid biopsy found EGFR exon 19 deletions in 11 samples (50%), exon 21 mutations (L861Q and L858R) in 10, L861Q in 7, L8585 in 6, and wild type in 1 sample. Additionally, acquired EGFR mutations in exon 20 T790M were found in 5 samples.Conclusions: Liquid biopsy may be beneficial in patients for whom tissue biopsy cannot be performed or where tissue for molecular profiling is inadequate. This modality can also be used to detect molecular resistance in patients with advanced NSCLC.
A Case Report of Radiation Therapy as Definitive Treatment for Desmoid Tumor in a Young Girl Rafiq Sulistyo Nugroho; Irma Darinafitri; Eviana Norahmawati; Istan Irmansyah Irsan; Satria Pandu Persada Isma
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.977

Abstract

Introduction: Desmoid tumor is a benign growth that can exhibit aggressiveness and various patterns, resulting in a wide range of management methods. These methods include observation to active interventions, such as surgery, radiation, and systemic therapy. Therefore, this case report aimed to present the role of radiation therapy for desmoid tumors in a young girl who refused limb amputation to preserve the organ.Case Presentation: This study presented the case of a 13-year-old girl with a vast and painful desmoid tumor in the left upper arm. Magnetic resonance imaging (MRI) on the left shoulder showed an 8 x 9 x 17 cm solid soft tissue mass on the left deltoid muscle with the necrotic component that expands to adjacent cutaneous and subcutaneous tissue. In this case, the left humerus attaches to the deep brachial artery and vein. Previous pathological studies with immunohistochemicals showed desmoid fibromatosis. A multidisciplinary team discussion led to the selection of, radiotherapy for treatment because of tumor localization and proximity to the critical structure. Radiation was also selected as the definitive therapy of choice with the aim of local control and organ preservation. Furthermore, the radiation dose was 56 Gy in 2 Gy per fraction over six weeks. After six months of follow-up, the patient reported pain relief, improved range of motion, and reduced tumor size.Conclusion: Radiotherapy reduced desmoid tumor size and improved symptoms without compromising organ function in young girls.
Effect of Inhaled Peppermint Aromatherapy on Chemotherapy-Induced Acute Nausea and Vomiting among Women with Breast Cancer in Gresik Regency Istiroha Istiroha; Roihatul Zahroh; Qonitatin Wafiyah; Yuanita Syaiful
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.987

Abstract

Background: Chemotherapy-induced acute nausea and vomiting are commonly experienced by breast cancer patients. Therefore, this study aimed to determine the effect of inhaled peppermint aromatherapy on chemotherapy-induced acute nausea and vomiting among women with breast cancer.Methods: This pre-experimental study was conducted using a one-group pre-post-test design approach. The sample included 28 women with breast cancer undergoing chemotherapy at the Chemotherapy Unit of Semen Gresik Hospital, Gresik, Indonesia. Respondents were administered 0.25 cc of peppermint essential oil on a cotton ball and then inhaled for 10 minutes. Data were collected using Rhodes Index Nausea Vomiting & Retching (RINVR) and analyzed with a paired sample t-test.Results: The pre-test showed that the majority of respondents experienced a moderate level of nausea and vomiting. After the intervention, the post-test results indicated mild nausea and vomiting. The statistical analysis showed that peppermint aromatherapy significantly affected chemotherapy-induced acute nausea and vomiting with a p-value of 0.001 (α<0.05).Conclusions: There was a significant improvement in chemotherapy-induced acute nausea and vomiting after the administration of peppermint aromatherapy. Therefore, this intervention could be used as a non-pharmacological complementary therapy to reduce chemotherapyrelated nausea among breast cancer patients

Page 41 of 41 | Total Record : 405

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