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Muhammad Iqhrammullah
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Narra X
Published by PT Narra Sains Indonesia
ISSN : -     EISSN : 29882990     DOI : DOI: https://doi.org/10.52225/narrax
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health
Narra X is a multidisciplinary journal, published three times in a year (April, August, and December). The journal aims to act as a platform for rapid scientific communication while upholding the highest integrity. Articles are published in a form of Original articles, Short Report, Case Reports, Methods articles, Review articles, and Letters to the Editor. All submitted articles are subjected to peer-review prior to their publication. As a multidisciplinary journal, Narra X welcomes articles from any subject field, depending on the editorial capacity. At the moment, Narra X is handled by section editors in the following fields: Health and medicine Chemistry Biology Mathematics Physics Narra X is online only journal and all articles do not have page numbers; instead, they are given a unique article number.
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Articles 11 Documents
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Coping strategies used by healthcare professionals during COVID-19 pandemic in Dubai: A descriptive cross-sectional study Ahmad Hamdan; Jennifer Eastaugh; Johan Snygg; Jennifer Naidu; Ibtisam Alhaj
Narra X Vol. 1 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i1.71

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has affected physical, social, and psychological well-being of all people, especially healthcare professionals (HCP), who are vulnerable to work-related stress. The aim of this study was to explore the effectiveness of coping strategies practiced by HCPs during the COVID-19 pandemic. A cross-sectional study was conducted in Mediclinic Welcare Hospital in Dubai during the pandemic between March 2020 and April 2021. The questionnaire was used to collect demographic data and validated Brief Coping Orientation to Problems Experienced (Brief-COPE) scales instrument was used to measure the coping strategies. A total 112 respondents were included in the final analysis consisting of physicians (11.6 %), nurses (60.7%), other clinical HCPs (24.1%), and non-clinical staff (7.2%). The common and effective coping strategies used by HCPs were within the problem-focused category. The female HCPs used multiple coping strategies to help them to manage their stress during COVID-19 pandemic. The nurses were more likely to report using emotional support as a coping strategy than doctors or other hospital staff members. Among 48.21% of the respondents that venting helped them release their feelings and distracted themselves through watching movies or television, reading, sleeping, or shopping. Moreover, 42.86% respondents found comfort in practicing religion and spiritual beliefs. Interestingly, the use of alcohol or other drugs was used as a coping mechanism during the pandemic, whereas emotional support and actions as well as taking other advice, were common strategies. Based on these data, healthcare institutions should consider a variety of support measures and programs for the mitigation of stress and negative emotional responses among HCPs during any future outbreaks or pandemics, such as providing access to mental health services, regular check-ins with colleagues or supervisors, peer support groups, educational resources on coping strategies, and paid time off for rest and recovery. Counseling and executive support services also could help staff to manage the mental health during future disasters.
Exergame for post-stroke rehabilitation among elderly patients: A systematic review and meta-analysis Teuku F. Duta; Ghina Tsurayya; Muhammad A. Naufal
Narra X Vol. 1 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i1.73

Abstract

Advancement in gaming technology, including exergame, is thought to offer a promising innovation in rehabilitative treatment owing to its interactive and joyful natures. Elderly, in addition to being prevalent in stroke, they have different perspectives and adaptability toward the utilization of exergame in post-stroke rehabilitation. The aim of this study was to evaluate the effectiveness of exergame-based rehabilitation in ameliorating stroke-associated cognitive impairment among elderly patients. This systematic review followed the Preferred Reporting Item for Systematic Review and Meta-Analysis (PRISMA) guideline. The literatures were retrieved from the searches on PubMed, Scopus, and Embase databases using a combination of ‘exergame’, ‘stroke’, and ‘elderly’ along with their respective synonyms. Included studies were controlled observational studies and randomized clinical trials with subjects’ mean age >60 years old, measuring global cognitive and/or five cognitive domains (attention, language, executive function, memory, and visuospatial ability). Quality appraisals were performed based on the Cochrane ‘risk-of-bias tool’ and Physiotherapy Evidence Database Scale. Studies with high and good qualities were included in the meta-analyses. Six randomized controlled trials involving 179 patients were included in meta-analysis. Studies had variations in terms of type (combination of exergame-based and conventional rehabilitation or exergame-based only) and duration of interventions (30–110 min), length of observation (2–6 weeks), and tools used to examine cognitive outcomes. As compared with conventional rehabilitation, exergame-based rehabilitation was significantly more effective to improve global cognitive based on Montreal Cognitive Assessment Score in acute stroke patients (n=4; mean difference (MD) 3.66; 95% confidence interval (95%CI): 2.08, 5.24; p<0.00001), but significantly less effective in chronic stroke patients (n=2; MD -1.54; 95%CI: -2.28, -0.81; p<0.0001). In conclusion, global cognitive of elderly patients with acute strokes could be improved through exergame-based rehabilitation which is more effective as compared with conventional therapy.
Achromobacter xylosoxidans as emerging pathogen in healthcare settings: A mini review Galo Farfán-Cano; Glen A. Silva-Rojas
Narra X Vol. 1 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i1.74

Abstract

Microorganisms of the genus Achromobacter have been mentioned as a cause of opportunistic infections, mainly in patients with cystic fibrosis or pulmonary lymphoma, with the species Achromobacter xylosoxidans being identified to a large extent. A. xylosoxidans was first described in 1971 and is an opportunistic pathogen. However, it been reported to cause chronic purulent otitis, meningitis, pneumonia, peritonitis and urinary tract infections, chronic obstructive pulmonary disease and other infections. The present literature review aims to analyze and synthesize the state of the art on A. xylosoxidans and its potential as an emerging pathogen in the healthcare settings. We discuss A. xylosoxidans as an emerging opportunistic pathogen that is associated with healthcare infections. This review further discusses the prevalence of A. xylosoxidans in healthcare settings, the types of infections it can cause, and the risk factors for acquiring an A. xylosoxidans infection. The review also covers the challenges in treating A. xylosoxidans infections, including its potential for drug resistance and the lack of specific treatments. Strategies for preventing and controlling A. xylosoxidans infections in healthcare settings were also discussed.
Association between admission blood sugar levels and length of stay among patients with acute heart failure: A cross-sectional study in Aceh, Indonesia Naufal Gusti; Teuku Heriansyah; Irwan Saputra
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.75

Abstract

Heart failure persists to be a major health problem worldwide. Numerous factors associated with this condition have been studied to determine its prognosis. History of diabetes mellitus is one of the factors extensively studied, nonetheless, the correlation between acutely elevated admission blood glucose in critically ill patients or stress hyperglycemia towards the prognosis of heart failure remains inconclusive among previously reported studies. Therefore, the aim of this study was to investigate the correlation between admission blood glucose and the length of stay of acute heart failure patients. A cross-sectional study was conducted in Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia from July to August 2020. Patients’ data were retrieved from medical records documenting admission blood glucose and length of stay. Total sampling was employed, where eighty-five patients diagnosed as acute heart failure were included. The results showed that patients (n=85) had the general characteristics of being normoglycemic on admission (69.4%) and having 5–10 days length of stay (44.7%) with Killip 2 as the presiding Killip Class (50.6%). According to Gamma’s Correlation Coefficient, the p-value of this study is 0.012 (p< 0.05) with a correlation value of 0.454. Therefore, our study revealed the presence of a significant moderate-correlation between admission blood glucose and the length of stay among patients with acute heart failure.
Antibacterial activity of Chrysophyllum albidium seed oil extract on pathogenic Staphylococcus aureus Martin C. Onuigbo; Chimere Y. Ukegbu; Kelechukwu C. Uzoigwe
Narra X Vol. 1 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i1.77

Abstract

Antimicrobial resistance in Staphylococcus aureus has continued to rise and has become a general medical problem. Thus, the objective of this study was to use the Chrysophyllum albidum seed extract as an antibiotic against pathogenic Staphylococcus aureus. The antimicrobial impact of Chrysophyllum albidum seed oil on pathogenic Staphylococcus aureus from various sources were explored utilizing agar well dissemination strategy. The oil was separated utilizing the Soxhlet extraction strategy with n-hexane as the solvent. The oil extract was then prepared in various concentrations (62.5–500 mg/mL) and tested against three different pathogenic isolates of Staphylococcus aureus. At the highest concentration (500 mg/mL), the oil extract yielded 22–24.6 mm inhibition zones. Meanwhile, at the lowest concentration (62.5 mg/mL), the inhibition zones achieved were 14.6–16 mm. The minimum inhibitory concentration was 125 mg/mL, while the mean minimum bactericidal concentration was 250 mg/mL. In conclusion, our data suggested that the oil from seeds of Chrysophyllum albidum has antibacterial activities against Staphylococcus aureus and this needs to be further studied.
Chemometric-empowered spectroscopic techniques in pharmaceutical fields: A bibliometric analysis and updated review Baidillah Zulkifli; Fajar Fakri; Joan Odigie; Loveday Nnabuife; Chinwe C. Isitua; Williams Chiari
Narra X Vol. 1 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i1.80

Abstract

Undeniable increase in pharmaceutical demand has encouraged researchers to develop analytical techniques to analyze drugs and monitor their effects. Chemometrics enabled simple spectroscopic approaches (such as infrared or UV spectroscopy) to analyze complex samples, including drug formulations, excreted fluids and tissues of living organisms. The aim of this study was to evaluate the research trend of this combinatorial technique utilized for pharmaceutical-related sample analysis using a bibliometric analysis. Bibliometric data of published literature from the Scopus database on March 14, 2023 were retrieved using the keyword combinations of "multivariate", "chemometrics", "pattern recognition", "drug", "pharmaceutical" and "spectroscopy". Network visualization analysis was performed using VOSviewer on the co-occurring keywords and authorships, presenting data such as top cited papers (n=10). The literature review was performed based on the research trend revealed by the clusters that emerged in the network visualization. The analysis revealed that the first paper was published in 1973 (n=1) and a total of 3544 records have been published as of March 14, 2023, comprising original research articles (n=3144, 88.71%) and review articles (n=232, 6.55%). The keyword “chemometrics” with Total Link Strength (TLS) of 826 emerged as the most abundant, followed by “metabolomics” (TLS=388), “Raman spectroscopy” (TLS=280), “metabonomics” (TLS=272), “nuclear magnetic resonance” or “NMR” (TLS=271), and “multivariate analysis” (TLS=254). Network visualization revealed that the research falls into two general categories: (1) drug toxicity and efficacy monitoring and (2) quality control of drug manufacturing. The top cited paper (n=3269) was a review article published in 1999 describing the utility of nuclear magnetic resonance combined with multivariate statistics for metabolite profiling of biological samples. The chemometric-empowered spectroscopy techniques were expected to provide objective measurement during clinical studies and monitoring of therapeutic effects.
Essential oils for COVID-19 management: A systematic review of randomized controlled trials Teuku F. Duta; Diva R. Rizki; Agnia Purnama; Marius Rademaker; Uwe Wollina; Yogesh Acharya; Ziad Abdeen; Sandro G. V. Rosa; Henning B. Nielsen; Kannan Subbaram
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.84

Abstract

Essential oils can be a beneficial adjuvant therapy in managing coronavirus disease 2019 (COVID-19). This systematic review aims to evaluate the efficacy of essential oils in ameliorative COVID-19-related symptoms. Published studies reporting the efficacy of essential oils as adjuvant therapy for COVID-19 were screened on Scillit, Scopus, SciFinder, and PubMed (December 7th, 2022). Inclusion criteria include the randomized controlled trials (RCTs) participated by those diagnosed with COVID-19 and treated with essential oils as adjuvant therapy. Quality assessment was carried out using Cochrane ‘risk-of-bias’ 2.0 tool. A total of 2112 records were retrieved from the initial screening, which was reduced to four publications (n=344 individuals). The foregoing studies reported that essential oils could improve the recovery rate, alleviate post-COVID-19 fatigue, and prevent disease progression. Regarding their potential antiviral activity, better designed studies are needed. In conclusion, essential oils as adjuvant therapy are beneficial in ameliorating mild COVID-19 symptoms.
Cancer in Indonesia: A bibliometric surveillance Muhammad Iqhrammullah; Randa Y. Refin; Rika I. Rasmi; Fina F. Andika; Hajjah Hajjah; Marlina Marlina; Ratna Ningsih
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.86

Abstract

Being archipelagic in geography and heterogenous in population contributes to the challenging comprehensive cancer surveillance in Indonesia. This present study analyzed the scientific publications on cancer epidemiology in Indonesia through bibliometric analysis aiming to complement the national survey data. The bibliometric data were retrieved from Scopus database on 9 May 2023 with pre-designed keyword combinations implying ‘cancer epidemiology in Indonesia’. The data were further presented in a table, distribution map, and visualized co-occurrence network. The visualization of co-occurring keywords was performed on VosViewer, and further analyzed qualitatively and quantitatively. We retrieved 1075 scientific records constituted of original articles (n=888, 82.6%), conference papers (n=102, 9.48%), and review articles (n=40, 3.72%) among others. The contributing affiliations are concentrated in Java Island, with Jakarta (n=603) as the province with the most publications. ‘Breast cancer’ (n=91) and ‘cervical cancer’ (n=39) emerged as the most frequently occurring keywords, and are assigned as the centers of research cluster, respectively. Keyword ‘breast cancer’ (total link strength, TLS=86) is connected with ‘colorectal cancer’, ‘metastasis’, ‘ovarian cancer’, and ‘prostate cancer’. Meanwhile, keyword ‘cervical cancer’ (TLS=35) is connected with ‘human papilloma virus’ and ‘knowledge’. The results are in line with the current epidemiological data of Indonesia, and they can provide different insights, especially on the research trend. Research and policy recommendations are presented in the last parts of this article.
Distribution and antimicrobial sensitivity pattern of multidrug-resistant Pseudomonas aeruginosa from the clinical specimen in Aceh, Indonesia Zinatul Hayati; Yulia S. Ismail; Suhartono Suhartono; Miftahul Zikra; Teuku F. Karmil; Ade Oktiviyari
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.87

Abstract

The development of P. aeruginosa resistance to antibiotics is increasing globally due to the inappropriate use of antibiotics. This retrospective descriptive study aimed to determine the distribution of multidrug resistant P. aeruginosa (MDRPA) and its antimicrobial sensitivity profiles. Data were taken from the bacterial identification and antibiotic sensitivity testing of clinical specimens in Aceh Provincial Referral Hospital from July 2017 to June 2019, where the VITEK® 2 Compact automatic device was used for the identification. In total, there were 307 P. aeruginosa isolates analyzed in this study. The results of this study revealed that 54.39% of P. aeruginosa isolates were multidrug resistant.  The MDRPA were mostly found in sputum and pus cultures (41.91% and 23.95%, respectively). Based on the wardroom as the source, most samples came from the internal medicine unit, intensive care unit, and surgical unit with prevalence of 27.54%, 25.74%, and 20.35%, respectively. High proportion of infected patients were male (52.09%) and aged 56–65 years (23.95%). P. aeruginosa showed the highest sensitivity rate to amikacin (77.1%), followed by meropenem (74.4%), ceftazidime (70.1%), levofloxacin (65.1%), tobramycin (64.9%), piperacillin-tazobactam (64.3%), and gentamicin (61.4%). In conclusion, our data suggest that the MDRPA infection is prevalent in Aceh Province and Amikacin is recommended as the highest standard of therapy for MDRPA.
Music therapy improves social interaction and verbal communication skill among children with autism spectrum disorder: A systematic review and meta-analysis Shakira Amirah; Muhammad F. Abdurrahman; Raihan F. A. Akbar; Intan C. Mulya
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.90

Abstract

The incidence of Autism Spectrum Disorder (ASD) is constantly increasing, in which 6 of 1000 ASD children are from Asia. Music therapy as a developing alternative is believed to improve communication and expression skills in children with ASD. Unfortunately, no specific meta-analysis has evaluated social interaction and verbal communication skills in children with ASD. Therefore, the aim of this meta-analysis was to evaluate music therapy in children with ASD. We performed a comprehensive literature review on PubMed, Scopus, Embase, Wiley, and Proquest to study the efficacy of music therapy as an ASD management therapy until October 20th, 2022. Twenty-three randomized controlled trials involving patients with ASD, where 1129 patients were assigned in the intervention group and 759 patients – in the control group, were included in qualitative and quantitative analysis. The pooled estimates revealed that music therapy increased the social interaction score with mean difference (MD)=2.08 (95% confidence interval [CI]: 0.35–3.81; p<0.02), social interaction score based on Autism Diagnostic Observation Schedule with MD: 0.77 (95% CI: 0.03–1.51; p<0.04), verbal communication skill based on Autism Diagnostic Interview-Revised with MD=0.90 (95% CI: 0.79–1.00, p<0.01). In conclusion, music therapy has excellent efficacy and strong potency as a part of ASD management. Nevertheless, more clinical trials with similar parameters are still required to confirm these findings.

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