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Malacca Pharmaceutics
Published by PT. Heca Sentra Analitika
ISSN : -     EISSN : 29881064     DOI : https://doi.org/10.60084/mp
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Malacca Pharmaceutics is a premier interdisciplinary platform dedicated to fostering the exchange of cutting edge research and ideas in the rapidly evolving fields of pharmaceutical science and technology. Our mission is to provide a comprehensive and authoritative forum for scientists, researchers, and practitioners from diverse disciplines to share and advance their knowledge in the development, optimization, and application of innovative therapeutic strategies. The scope of the Malacca Pharmaceutics Journal encompasses a wide range of topics, including, but not limited to:Pharmaceutical formulation, delivery and controlled-release systems for drugs, vaccines, and biopharmaceuticals, pharmaceutical process, engineering, biotechnology, and nanotechnology, devices, cells, molecular biology, and materials science related to drugs and drug delivery pharmacogenetics and pharmacogenomics, biopharmaceutics,nanomedicine, drug targeting, drug design, pharmacokinetics, toxicokinetics, pharmacodynamics, drug discovery, drug design, medicinal chemistry, combinatorial chemistry, SAR, structure-property correlations, molecular modeling, pharmacophore, and bioinformatics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
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Search results for , issue "Vol. 2 No. 1 (2024): March 2024" : 5 Documents clear
Evaluating the Efficacy of Clerodendrum minahassae Ethanol Extract on Insulin Regulation in Diabetic Wistar Rats Chrisa P. Rumangu; Fatimawali Fatimawali; Aaltje Ellen Manampiring; Billy Johnson Kepel; Fona Dwiana Hermina Budiarso; Widdhi Bodhi
Malacca Pharmaceutics Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i1.137

Abstract

Leilem plant (Clerodendrum minahassae Teisjm & Binn.) from the genus Clerodendrum has the potential as antidiabetic, antihypertensive, anti-inflammatory, antioxidant, antimalarial, antitumor, antidiarrheal, antimicrobial and antihyperlipidemic. This study aimed to see the effect of ethanol extract of Clerodendrum minahassae (CM) leaves on increasing insulin levels in diabetic Wistar rats induced with streptozotocin. This study was conducted in vivo, using 20 rats as experimental animals. The experimental animals were divided into four groups, namely the negative control group (Na-CMC 0.5%), the ethanol extract group of leilem leaves 250 mg and 500 mg, and the positive control group (glibenclamide) as a comparison. Each experimental animal was induced streptozotocin intraperitoneally; then, each solution was given for 14 days according to the test group. After the treatment, the animals were terminated for blood collection; the blood was then centrifuged to obtain blood plasma serum. Blood plasma serum was measured by the ELISA Kit (Rat/Mouse Insulin) method, and then the results were read on a spectrophotometric device. The results of the sample insulin concentration obtained showed that 250 mg/kgBW and 500 mg/kgBW of the CM ethanol extract group could increase insulin levels in diabetic Wistar rats, the same as the positive control group glibenclamide. In contrast, the Na-CMC 0.5% as a negative control group did not show a significant increase in insulin levels. Leilem leaves can be developed for further research on their antidiabetic activity both in vitro, in vivo, and in silico, as well as their toxicity.
Probiotics and Their Role in Decreasing Diarrhea Prevalence in the Elderly Population: A Comprehensive Meta-Analysis Devika Muliana; Vera Dewi Mulia; Hijra Novia Suardi; Nanda Ayu Puspita; Suryawati Suryawati
Malacca Pharmaceutics Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i1.143

Abstract

Diarrhea is an atypical state of the digestive system characterized by a soft or watery texture in bowel movements. Antibiotic-related diarrhea is common in the elderly due to extensive antibiotic use. Probiotics are vital microorganisms that support the intestinal flora and reduce bacterial colonization in the intestinal wall. This study aimed to assess the effectiveness, type, and dose of probiotics for diarrhea in the elderly. A systematic review with meta-analysis was conducted using PubMed, ScienceDirect, and Google Scholar. Seven records with a total of 2,087 participants were included. A quantitative analysis was carried out using Review Manager version 5 software. A meta-analysis was conducted to assess the frequency of diarrhea. The results showed that using probiotics significantly reduced the risk of antibiotic-related diarrhea 0.53 times compared to the placebo administration (OR 0.53; CI 95% 0.29 to 0.98; I2 = 70%). The type of probiotics frequently given was the genera of Lactobacillus, Bifidobacterium, and Streptococcus, with consumption durations varying from 3 days to a maximum of 4 weeks. The dose of probiotics ranged from a minimum of 1.0 × 10⁶ CFU to a maximum dose of 2 × 10¹⁰ CFU. To conclude, probiotic administration is more effective than placebo in reducing the risk of antibiotic-related diarrhea in the elderly.
The Potent Antimicrobial Spectrum of Patchouli: Systematic Review of Its Antifungal, Antibacterial, and Antiviral Properties Pati Kemala; Rinaldi Idroes; Khairan Khairan; Muliadi Ramli; Trina Ekawati Tallei; Zuchra Helwani; Sunarti Abd Rahman
Malacca Pharmaceutics Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i1.156

Abstract

ntention towards natural essential oils from medicinal plants has increased rapidly over the past decade as these oils have antimicrobial and antioxidant properties against various chronic diseases. One essential oil source with antimicrobial properties is the essential oil from Pogostemon cablin (Blanco) Benth. This review aims to provide information on using patchouli oil as an antimicrobial against bacterial, fungal, and viral pathogens in the last five years. There were 37 articles found in the PUBMED database by June 15, 2023. After searching, 6 of them were duplicates. A total of 2 papers were inaccessible, 4 were not research articles, and five were excluded because they were irrelevant to the scope of this study. This review shows that research related to patchouli as an antimicrobial in the last five years involves Pogostemon cablin leaf samples as silver nanoparticle bioreductors. Patchouli oil is used in membrane, nanocomposite film, and starch hydrogel manufacturing. Patchouli oil is a prestigious antimicrobial agent because it can fight numerous pathogenic microbes from bacteria, fungi, and viruses.
Network Pharmacology Approach to Understanding the Antidiabetic Effects of Pineapple Peel Hexane Extract Christa Hana Angle Pendong; Elly Juliana Suoth; Fatimawali Fatimawali; Trina Ekawati Tallei
Malacca Pharmaceutics Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i1.162

Abstract

The increased interest in exploring alternative treatments for type 2 diabetes mellitus is accompanied by a rise in the prevalence of type 2 diabetes mellitus. Pineapple peel is one of the by-products of pineapple fruit and is known to possess potential for anti-diabetic activity. In this study, the n-hexane extract of pineapple peel was analyzed using network pharmacology methods to ascertain its potential in treating type 2 diabetes mellitus. The GC-MS analysis of the n-hexane extract of pineapple peel revealed the presence of 42 compounds, with 8 of them considered safe as they met the Lipinski Rule of Five criteria for drug-likeness and were classified as safe with toxicity levels in classes IV and V. The pineapple peel extract targeted 55 proteins related to type 2 diabetes mellitus (DMT2), potentially affecting DMT2 through the AGE-RAGE pathway in diabetes complications and insulin resistance. Network pharmacology analysis identified five genes targeted by pineapple peel, namely MAPK1, JAK2, MAPK8, PRKCD, and PPARA. Among these genes, MAPK1 exhibited a higher overall score than the others. Apart from its role in diabetes, MAPK1 is also implicated in cancer.
Exploring the Medicinal Potential of Blumea balsamifera: Insights from Molecular Docking and Molecular Dynamics Simulations Analyses Nur Balqis Maulydia; Khairan Khairan; Trina Ekawati Tallei; Salaswati Salaswati; Annisa Musdalifah; Fiki Farah Nabila; Rinaldi Idroes
Malacca Pharmaceutics Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i1.168

Abstract

Blumea balsamifera from the Ie-Jue geothermal area in Aceh Province, Indonesia, has been reported to have a variety of secondary metabolites. However, there is limited information about the activity of these chemical metabolites from B. balsamifera. The aim of this study is to evaluate the therapeutic potential of these compounds using molecular docking and molecular dynamics simulations. Six selective compounds were thoroughly evaluated using molecular docking techniques for their inhibitory effects on both Coronavirus protease and human interleukin receptors. Additionally, druglikeness assessments based on the Lipinski rule of five were performed to evaluate these six ligands. Our results show that stigmasterol, a key component of B. balsamifera, has demonstrated low binding free energy values across four receptors. Furthermore, molecular dynamics simulations confirmed the stability of the top ligand-receptor complex, particularly stigmasterol-1IRA, based on five parameters, indicating its stability as an inhibitor. This research highlights the potential of stigmasterol as a therapeutic agent derived from medicinal plants of B. balsamifera and underscores the value of our molecular approach in identifying opportunities for pharmaceutical development.

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