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Magna Neurologica
Published by Universitas Sebelas Maret
ISSN : 29636027     EISSN : 29853729     DOI : https://doi.org/10.20961/magnaneurologica.v1i2.647
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Magna Neurologica is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcomed.
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 11 Documents
 1   2 
Neurological Complications After Covid 19 Vaccinations: Serial Case Report Intan Permata Sari; Hanindia Riani Prabaningtyas
Magna Neurologica Vol. 1 No. 1 (2023): January
Publisher : Neurologi Departement Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i1.430

Abstract

Background: COVID-19 vaccination has been carried out worldwide, with more than 5 million dose of vaccine delivered. Although declared safe, there are cases of neurological disorders after the Covid 19 vaccination. Cases: In the first case, a 20-year-old male came with decrease level of consciousness, 4 days after receiving the first dose of COVID 19 vaccine with Sinovac vaccine. MRI Brain shows acute disseminated encephalomyelitis (ADEM). In the second case, a 50-year-old male with seizures and decreased consciousness after recieving first dose of COVID-19 vaccination with Sinovac vaccine, 10 days before admission. Non contrast CT Scan and brain contrast MRI Brain revealed cerebral edema. In the third case, an 18-year-old woman had seizures and decreased consciousness one month after the first dose of COVID 19 vaccination with Sinovac. Contrast Head MRI showing focal leptomeningitis. In the fourth case, a 30-year-old male with slurred speech and right-sided weakness. Three months before admission, he had fever, headache, and tingling of the right limbs a few days after the first dose of COVID 19 vaccination with Sinova MRI Brain Contrast shows ADEM lesion Discussion: The mechanism of neurological disorders concerning COVID 19 vaccination is still unclear. Neurological complications after vaccination weaken the effort of vaccination, but can be used as a precaution and assess prognosis while waiting for further confirmation from large epidemiological studies and meta-analyses. Until now, it is believed that the COVID-19 vaccine has important benefits and is a hope for ending the COVID-19 pandemic.
Morse Fall Scale As Clinical Predictor Of 3-Month Neurologic Function Recovery On Ischemic Stroke Patients: A Prospective Cohort Study Triono Agung Sakti; Baarid Luqman Hamidi; Hanindia Riani Prabaningtyas
Magna Neurologica Vol. 1 No. 1 (2023): January
Publisher : Neurologi Departement Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i1.431

Abstract

Background: Stroke is a leading cause of death in developing countries. The Morse Fall Scale (MFS)'s use in predicting stroke clinical outcomes has not been extensively studied. This study aims to assess MFS's ability to predict neurological recovery in acute ischemic stroke patients within 3 months using the National Institutes of Health Stroke Scale (NIHSS). Methods: This prospective cohort study enrolled all individuals with acute ischemic stroke between September and November 2021. Patients' baseline data included their MFS and NIHSS scores, as well as their age, gender, weight, stroke location, and comorbidities. The NIHSS score was reassessed three months later. To identify NIHSS predictors, all baseline data will be analyzed. SPSS 22 was used to analyze the data. The local ethics committee approved the study. Results: Of the 164 patients who met the criteria, only 105 (mean age 59.09 [±11.65], male [58.1%], anterior location [88.6%]) reached the study end point. The average NIHSS score decreased from 9.14 (±1.70) to 6.27 (±1.92). Multiple linear regression showed only the MFS score (p = 0.000) accurately predicted the NIHSS by 0.059 (95% CI: 0.032–0.085, p = 0.000) at the study's conclusion. Discussion: Our investigation revealed that the baseline MFS score accurately predicted neurological improvement in patients who had suffered an ischemic stroke over a three-month period. It is considered that the greater risk of falling results in a delay in the patient's rehabilitation. Investigation with larger sample sizes and longer monitoring intervals are required to corroborate our findings.
Cognitive Function Analysis Using Telephone-Moca On Resident With Post Covid-19 Infection In Dr. Moewardi Hospital 2020-2021 Befrie Mahaztra Sudarman; Rivan Danuaji
Magna Neurologica Vol. 1 No. 1 (2023): January
Publisher : Neurologi Departement Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i1.450

Abstract

Introduction: Individuals after Covid-19 infection are suspected to have symptoms of cognitive impairment. Researchers wanted to use the telephone version of MoCA-22 assessment to assess cognitive function. Method: Cross-sectional study at Dr. Moewardi Hospital, Surakarta. Researchers assessed cognitive function telemedicine using Telephone-MoCA 22 and then compared it with the 30-point standard MoCA-INA examination. The analysis is continued on the results of inspection of each component. Results: During 2020-2021 there were 191 Residents who were infected with Covid-19. After screening, 69 people were able to complete the study, of which 34 people with a history of Covid-19 infection (49,2%) and 35 people (50,8%) without a history of Covid-19 infection. The subjects consisted of 34 men (49,2%); 35 women (50,8%); age range 25-33 (±28.97) years; Education grade is 28 juniors, 27 intermediate, and 17 seniors Resident. In the regression test, it was found that effect of Covid-19 history on cognitive function with p-value = 0,94 if using MoCA 30, and p-value = 1,17 if using T-MoCA 22. Comparative test of the two assessments obtained p-value = 0.475. In the analysis of each component obtained less than the maximum value on components of calculation, repetition and delayed memory. Conclusion: In the study, it was found that a history of Covid-19 infection had no effect on cognitive function in research subjects tested using MoCA-INA or Telephone-MoCA. T-MoCA examination has a test value that is not significantly different from the full version of MoCA 30 points.
Clinical Profile And Risk Factors Of Stroke: A Comparative Analytical Study Between Young And Old Onset Reza Stevano; Jacqueline Tasha Margono; Anyeliria Sutanto
Magna Neurologica Vol. 1 No. 1 (2023): January
Publisher : Neurologi Departement Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i1.470

Abstract

Background: With ever-increasing incidence, young-onset stroke is responsible for significant psychosocial and economic burden, primarily due to post-stroke disability in the productive population. Objective: The aim of our study is to assess the profile and risk factors in young-onset stroke compared to those in older patients. Methods: This was a retrospective cross-sectional study. We included all patients with acute stroke, or transient ischemic attack (TIA) treated at Siloam Lippo Village Hospital between October 2021 and February 2022. An independent t-test was conducted for continuous variables with normal distribution and a Mann-Whitney U test for ordinal or continuous variables with non-normal distribution. Pearson's chi-square test was performed for categorical variables. Results: 153 patients with acute stroke and TIA were included. On univariate analysis comparing young and old-onset strokes, significant differences were found in diagnosis (p=0.039), Bamford classification (p=0.022), NIHSS (p=0.014), history of smoking (p=0.012), previous stroke (p=0.045), history of coronary artery disease (p=0.026), and routine antiplatelet use (p=0.018). Conclusion: We found a predominance of hemorrhagic stroke and TIA in the young-onset group, with more common involvement of the anterior circulation. Older onset was associated with a higher NIHSS score. Modifiable risk factors are more common in young-onset stroke, while non-modifiable risk factors are more common in the older population. However, hypertension remains an equally important risk factor in both groups. Our study provides an overview of the profile and risk factors for young-onset stroke. The information obtained can be useful as educational material for the community to prevent young-onset stroke.
Septic Cavernous Sinus Thrombosis (CST) with Blindness Caused by Odontogenic Infection – A Case Report Putri Permata Valentine; Yudhi Adrianto; Sita Setyowatie
Magna Neurologica Vol. 1 No. 1 (2023): January
Publisher : Neurologi Departement Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i1.477

Abstract

Introduction: Septic cavernous sinus thrombosis (CST) is a rare thrombosis, but severe, causing damage to all nerves inside the cavernous sinus. The incidence rate of CST is estimated at two to four per million people per year. The symptom usually varies, gradually worsening, making diagnosis harder and potentially making permanent disability. Early detection and prompt treatment are very important to lower the morbidity rate. Case: Tn. M had complained of multiple headaches attacks since 8 months ago before being admitted followed by diplopia. Complaints had worsened 3 months before with the loss of vision in the left eye. MRI showed left thrombosis sinus cavernous. The terrible headache was scaled 8-9 with VAS score. The patient’s left eye was found proptosis palpebra, with anisocoria and mydriasis followed by no direct light reflex also indirect light reflex, visual acuity of the left eye is no light response, whereas the patient’s right eye is normal. On the patient’s left eye was found gaze palsy sinistra. The abnormal blood result was leucocytosis and thrombocytosis. The patient was given fondaparinux once a day with a dose of 6000 units subcutaneously for 5 days. After that, the headache was decreased significantly. The patient underwent 5 tooth extraction done by mouth surgeon after being discharged. The patient was given 20 mg rivaroxaban per day for three weeks, then 10mg per day for three months, and evaluated with MRV again. Conclusion: CST is still very rare but very lethal and makes permanent disability on the patient. Through this case, we demonstrate the potential of tooth infection which leads to septic CST and caused ophthalmoplegia and blindness.
Insomnia During The Covid-19 Pandemic and Its Relationship with Psychological Distress in Healthworkers : A Literature Review Yullytia Franika Maryati; Ross James Godwin; Saiful Hidayat
Magna Neurologica Vol. 1 No. 2 (2023): July
Publisher : Neurologi Departement Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i2.630

Abstract

Background: The global COVID-19 pandemic has had a significant impact on all aspects of daily life. One area it has impacted on is psychological stress experienced by health workers, particularly sleep disorders.  The development of sleep disorders such as insomnia may affect the wellbeing of health care workers. This literature review aims to summarize the evidence concerning insomnia during the COVID-19 pandemic and its relationship to psychological distress in healthcare workers and to detect associates stress symptoms with sleep quality in health workers. Methods: This study is a literature review constructed by searching articles through the Pubmed and Science Direct electronic databases using a combination of keywords, including articles published from 2020-2022, analyzing the effect of insomnia during the COVID-19 pandemic and its relationship with psychological stress. The review process used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) as a guide. Results: A total of five articles were analyzed. Three studies indicated that insomnia was associated with stress symptoms even with low exposure to COVID-19 patient care. Two other articles showed that psychological distress has a negative impact on sleep quality to such a level that it interferes with daily activities. Conclusion: Sleep disorders, including insomnia, are related to psychological distress in health workers in the COVID-19 pandemic era. Providing social and psychological support to health workers is crucial because the emotional well-being of health workers affects the quality of patient care, and subsequently the effective functioning of health services.
Attenuation of Neuronal Tissue Damage in Ischemic Stroke by Tat-NR2Bct-CTM and Tat-NR2B9c Benedictus Benedictus; Kenneth Tan; Vincent Kurniawan Putra Pratama; Jonathan Daniel Sulastyo
Magna Neurologica Vol. 1 No. 2 (2023): July
Publisher : Neurologi Departement Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i2.647

Abstract

Background: Worldwide, stroke accounts for 15 million cases annually. Despite improved understanding of its pathophysiology, an effective treatment is yet to be available. This review aims to expound ischemic stroke pathophysiology from a bio-molecular perspective, and present two peptides, namely Tat-NR2B9c and Tat-NR2Bct-CTM, which has been proven to attenuate neuronal tissue damage in ischemic stroke. Methods: Scoping review of several electronic databases: PubMed, Medline, Researchgate, NCBI, SpringerLink, and Google scholar. Search query included: ischemic stroke, NR2B, DAPK1, nNOS, NOX, Tat-NR2Bct-CTM and Tat-NR2B9c. Results:  It is recognizable in a sense, that the pathophysiology pivots on the NR2B-DAPK1 and PSD-95-NR2B interactions. Tat-NR2Bct-CTM and Tat-NR2B9c thwarts NR2B-DAPK1 and PSD-95-NR2B interactions, respectively. These peptides show significant reliability, with the former capable of reducing free DAPK1 by 92,85%, and the latter, the first stroke treatment in two decades to reach Phase 3 clinical trials. Conclusion: These results strongly support Tat-NR2Bct-CTM and Tat-NR2B9c as effective means to reduce neuronal tissue damage in ischemic stroke.
Delayed Facial Palsy: Uncommon Complications Of Microvascular Decompression For Hemifacial Spasm Faris Khairuddin Syah; Ervina Hutabarat
Magna Neurologica Vol. 1 No. 2 (2023): July
Publisher : Neurologi Departement Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i2.652

Abstract

Background: Microvascular Decompression (MVD) is considered the most effective treatment for reducing hemifacial spasm (HFS) and achieving long-term resolution. However, in rare cases, this procedure can lead to delayed facial palsy, characterized by facial weakness occurring more than 24 hours after surgery. Case: A 50-year-old woman complaining of twitching in the right face, from the corner of the eye to the eyebrows and mouth, for 2 years. The Brain MRI-FIESTA examination revealed a neurovascular attachment between the right facial nerve and the right posterior inferior cerebellar artery. Despite receiving medical treatment, the patient experienced dissatisfaction due to incomplete symptom remission and drowsiness caused by drug side effects. After the patient undergoes MVD, the twitches disappeared. However, twelve days later, the patient developed right facial weakness, and after three months of rehabilitation, facial weakness was resolved. Discussion: HFS is a rare condition characterized by involuntary facial twitches that can significantly disrupt daily activities, despite being painless. Proper management according to patient needs and the choices of HFS management include medications, botulinum toxin injection, and MVD. The potential side effects of each procedure should be carefully considered when making treatment decisions. It is crucial to thoroughly evaluate and monitor post-surgical conditions. Delayed facial weakness may be attributed to gradual edema occurring after surgery. The use of Teflon to separate nerve tissue and blood vessels, although beneficial, can sometimes be perceived as a foreign body leading to inflammation. Facial weakness can be managed with facial muscle exercises without requiring special treatment.  
The Impact Of 'Long Covid-19' Symptoms On Stroke Patients During The Covid-19 Pandemic Wahyu Dwihardi Raputra
Magna Neurologica Vol. 1 No. 2 (2023): July
Publisher : Neurologi Departement Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i2.655

Abstract

Background: Coronavirus disease 2019 (COVID-19) has become a global pandemic, affecting millions of people. However, the relationship between Covid-19 and acute cerebrovascular diseases is unclear. Objective: This study aims to examine the potential effect of long COVID-19 on stroke patients. Methods: A descriptive approach was employed in this study to effectively portray and elucidate the facts, data, and information that were gathered from literature studies, including books, journals, and, and results related to the topic. Results: The results showed that stroke sufferers experienced several impacts due to their long Covid conditions. These perceived effects ranged from seizures to cognitive impairment or brain fog, encephalitis, as well as other symptoms that are likely to aggravate the condition of stroke sufferers. Conclusion: The presence of the pandemic has introduced further obstacles for stroke patients who are also dealing with long COVID-19 conditions. If left unattended, these challenges can result in heightened complications, severity, comorbidities, and eve death. Therefore, the government needs to prioritize the prevention and control of long Covid condition among patients to minimize its impacts and effects.
Cases Of Meige’s Syndrome Controlled Following Administration Of Low-Dose Botulinum Toxin Type-A: A Serial Case Series Retno Jayantri Ketaren; Jacqueline Tasha Margono; Reza Stevano
Magna Neurologica Vol. 1 No. 2 (2023): July
Publisher : Neurologi Departement Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i2.700

Abstract

Background: Meige syndrome is a form of cranial dystonia characterised by blepharospasm and oromandibular dystonia, with a twice-fold higher prevalence in women as compared to men. The definitive pathophysiology underlying Meige syndrome remains unknown, but some studies have postulated the role of striatal dopaminergic activity. Currently, no curative treatments are available for Meige syndrome, but non-specific modalities include oral agents such as anti-cholinergics, dopaminergics, and benzodiazepines. Botulinum toxin Type-A (BoNTA) constitutes an effective treatment option in cases of Meige syndrome refractory to oral management. Case summary: We report three cases of female patients, age 42, 57, and 61 years, presenting with complaints of blepharospasm and oromandibular dystonia. Low-dose BoNTA injections were administered, 10 units total weekly divided into the orbicularis oculi, corrugator supercilii, frontalis, procerus, nasalis, zygomaticus, mentalis, dan risorius, and orbicularis oris areas. Following repeated administrations of BoNTA injections, the three patients no longer experience symptoms up till now. Conclusion: The authors report that low-dose BoNTA injections are effective in ameliorating dystonic symptoms associated with Meige syndrome, with low incidences of side effects.

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