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Bioactivities
Published by Pandawa Institute
ISSN : 2963654X     EISSN : 2963654X     DOI : https://doi.org/10.47352/bioactivities
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Bioactivities is a double-blind peer-reviewed journal for research activity on bioactivities of materials or compounds. This journal aims to provide a means for sustained discussion of relevant issues that fall within the focus and scopes of the journal which can be examined empirically in the following fields: 1) antioxidant; 2) antibacterial; 3) antifungal; 4) antiviral; 5) antibiotic; 6) anticancer; 7) antitumoral; 8) anti-fouling; 9) anti-inflammatory; 10) antihypertensive; 11) anti-obesity; 12) antiproliferative; 13) anti-opioid; and 14) biosorption. The Bioactivities is an open-access journal containing original research articles, review articles, and short communications in the areas related to bioactivities. The Bioactivities publishes 2 issues in a year in June (first issue) and December (second issue). This journal has adopted a double-blind reviewing policy whereby the referees and author(s) remain anonymous throughout the process.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Vol. 1 No. 2 (2023): Bioactivities" : 5 Documents clear
The Role of Flavonoids as Potential Plant Fungicides in Preventing Human Carcinogenesis: A Short Communication Katrin Sak
Bioactivities Vol. 1 No. 2 (2023): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.187

Abstract

In the context of the steadily increasing prevalence of malignant disorders all over the world, identification of any novel possibilities for suppressing carcinogenesis is crucial leading to saving human lives. One of the important sources of exposure to potential carcinogens is food products which can be contaminated with different types of mycotoxins. These structurally diverse chemicals are produced by certain fungi, whereas many of them may be associated with the development of malignant neoplasms in distinct organ systems. In this perspective article, the ability of specific plant secondary metabolites from the class of flavonoids to suppress the release of carcinogenic mycotoxins from certain fungi, mostly the members of Aspergillus and Penicillium genera, is highlighted. This finding might support the development of novel flavonoid-based plant fungicides in the future, to lower the contamination of food products with mycotoxins and thereby also reduce the cancer prevalence in humans. In addition, the application of flavonoids as natural products instead of synthetic chemicals in plant cultivation is probably also more acceptable for final consumers, representing an actual step toward a greener future.
The Journey of Natural Products: From Isolation Stage to Drug’s Approval in Clinical Trials Yehezkiel Steven Kurniawan; Tantiana Indriani; Hanif Amrulloh; Langit Cahya Adi; Arif Cahyo Imawan; Krisfian Tata Aneka Priyangga; Ervan Yudha
Bioactivities Vol. 1 No. 2 (2023): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.190

Abstract

Nature serves as an excellent inspiration for researchers in the fields of chemistry and medicine. Terrestrial or marine organisms produce billions of natural products with unique chemical and physical properties. Some of them have been used in traditional therapy for specific diseases since ancient times. Although their exact chemical structures have yet to be elucidated clearly in that time, investigations in medicinal chemistry have been well documented. Furthermore, utilizing natural products in drug design and development offers advantages such as high biocompatibility, low toxicity, fewer side effects, wide bioactivities, and large structure diversity. Nowadays, rational drug research using computer-aided drug design is well established to cut the long way of drug discovery and overcome the resistance cases and the increment in the number of active patients. This review will highlight some natural products to comprehensively understand their journey from unknown natural products, isolation, purification, characterization, in silico evaluation, bioactivity screening assay, drug modifications, in vitro investigation, in vivo examination, and clinical trial.
In silico Exploration on The Potency of Basil (Ocimum basilicum) as an Anti-Aging Skin Agent Wega Nasyita Amala; Raden Ahmad Zainul Aziz; Nur Rohmah; Hanun Najah Imtiyaz; Muhamad Dandi Iqbal Iskandar; Erlix Rakhmad Purnama
Bioactivities Vol. 1 No. 2 (2023): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.193

Abstract

New and improved skin care products and procedures have been established by technological advances and scientific investigation. By increasing the skin's moisture, firmness, and elasticity, anti-aging skin care can enhance the skin's overall condition. The objective of this study was to examine the potential of basil's chemical compounds as an in silicoanti-aging agent. Exploration of online databases, scholarly articles from national and international journals, and analysis using docking software are selected as examples of data collection methods. Matrix metalloproteinase 1 (MMP1), with PDB code 966C, is one of the targeted proteins related to skin anti-aging. Ladanein, acacetin, luteolin, 5-hydroxy-7,4'-dimethoxyflavone and genkwanin are five basil compounds that are predicted to exhibit anti-aging agents based on the presence of the binding affinity score indicator and the similarity of the appropriate attachment sites compared to the native ligand used. The scores for the binding affinity of luteolin, ladanein, acacetin, 5-hydroxy-7,4'-dimethoxyflavone, and genkwanin are -10, -9.9, -9.9, -9.8, and -9.6 kcal/mol, respectively. At the attachment positions of five basil compounds, the interactions with ASN 180, LEU 181 and ALA 182 key amino acids, which are the attachment sites for the native ligands, were also formed.
Antibacterial Effect of Juglans regia, Citrus sinensis, Vicia faba, and Urtica urens Extracts under In vitro Conditions Ali Khakpour; Negar Ahmadi Shadmehri; Hanif Amrulloh; Hamed Kioumarsi
Bioactivities Vol. 1 No. 2 (2023): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.195

Abstract

Various agricultural products are known to have anti-microbial, anti-cancer, and anti-inflammatory effects. As we can mention, Walnut (Juglans regia) husk, orange (Citrus sinensis) peel, Broad bean (Vicia faba) peel, and Nettle (Urtica urens) are proven to have antimicrobial and anticancer actions. Also, plant diseases such a Pectobacterium carotovorum, Ralstonia solanacearum, Dickeya chrysanthemi, and Pseudomonoas syringae are known to cause annual damage to plant products. Therefore, in the current study, the researchers evaluated their antibacterial activity on the mentioned bacteria under in vitro conditions. Extracts of J. regia husk, C. sinensis peel, V. faba outer peel and U. urens were prepared by maceration method and their anti-bacterial activity on P. carotovorum, D. chrysanthemi, P. syringae, R. solancearum was evaluated using blank disk and well diffusion to obtain minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. J. regia (husk) and V. faba (outer peel) extracts revealed an anti-bacterial effect on all 4 studied bacteria, while C. sinensis (peel) only inhibited the growth of P. syringae and U. urens only had this effect on P. syringae and R. Solancearum. The inhibition zones varied from 8 to 14 mm, while almost all MIC and MBC rates were 6.25 and 12.5 mg/mL, respectively. Based on the antimicrobial results, the extracts that showed suitable antibacterial effects on certain bacteria can be further studied to be used as natural pesticides.
In Vitro Antibacterial Activity and Phytochemical Screening of Galoba (Hornstedtia alliaceae) Seeds Extract Melfan El Shaday Sule; Eka Astuty; Ritha Tahitu
Bioactivities Vol. 1 No. 2 (2023): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.196

Abstract

Hornstedtia alliacea has been traditionally used by indigenous people for a variety of medicinal purposes. This study aimed to determine the antibacterial activity of ethanol extracts of Galoba seeds (Hornstedtia alliacea) against standard bacterial cultures of Staphylococcus aureus (ATCC-29213) and Escherichia coli (FNCC-6183) using Kirby-Bauer disk diffusion method. The phytochemical tests were carried out to determine the presence of active substances which are antibacterial in the results of the extraction. The color intensity or the precipitate formation was used as analytical response to these tests. The major phytochemical constituents identified in galoba seeds ethanol extracts were tannins, flavonoids, saponins, quinones, and steroids. The antibacterial assay showed that galoba seed extract inhibited the growth of S. aureus and E. coli. The diameter of the inhibition zone increased as the extract concentration increased. The largest inhibition zone for S. aureus was at a concentration of 100% with a diameter of 20.93 mm and the largest inhibition zone for E. coli was at a concentration of 100% with a diameter of 18.05 mm. The results of this study indicated that the plant contains some major bioactive compounds that inhibit the growth of microorganisms, thereby showing great potency as an effective source of drugs. The phytochemical analysis also reveals that the plant contains similar constituents useful for medicinal purposes.

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