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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 13 Documents
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Search results for , issue "Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)" : 13 Documents clear
Case Report: Hyperglycemia in Pregnancy and The Impacts on Fetal Welfare Stella Andani
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i5.37831

Abstract

Background: Hyperglycemia in pregnancy is related to the outcome of pregnancy. According to the American Diabetes Association, diabetes diagnosed in the second or third trimester of pregnancy without a history of diabetes is associated with macrosomia, perinatal complications, and neonatal and maternal morbidity.Case Presentation: This study involved 3 pregnant women with different characteristics of age, parity, and gestational age. All the women in the cases were found to have high glucose levels in the 2nd trimester of pregnancy and received therapy.Conclusion: Based on observational studies, patients with pregestational DM have better outcomes if the HbA1c level is <6-6.5%. In the second and third trimesters, the risk of macrosomia, preterm delivery, and preeclampsia is lower if the HbA1c level is <6%. Keywords: BMI, Diabetes Gestational, Glucose level, Pregestational Diabetes 
Phytochemicals as a potential inhibitor of Spike Protein of SARS-CoV-2 Omicron Variant Tuti Ratnasari; Faizah Fulyani; Endang Mahati
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i5.39577

Abstract

Background: More than 50 mutations have been found in Omicron SARS-CoV-2. Most Omicron mutations are located in the spike protein, which plays a pivotal role in virus infection. The mutated spike protein in the Omicron variant increases virus transmissibility and potentially threatens the effectiveness of COVID-19 vaccines and antibody therapies. Herbal plants, such as Indian Ayurveda, African herbal plants, and Traditional Chinese Medicines (TCM), have been studied as SARS-CoV-2 potential therapy in several countries.Objective: This review explores potential phytochemical herbals that target spike protein omicron based on the available molecular docking studies.Methods: We collected research articles on the molecular docking of phytochemicals that target spike protein omicron. Combination of several keywords: in silico OR molecular docking AND spike omicron, were used as input for Google search. Out of 83 articles from Google search, eight articles matched the inclusion criteria and were selected in this review.Result: Protodioscin from Carica papaya and Landomycin A from Aloe vera are the most potential phytochemical inhibitors against spike protein with the free binding energy of -10.77 kcal/mol and -10kcal/mol, respectively.  
Level Of Patient Satisfaction With Pharmaceutical Services In The Outpatient Pharmaceutical Room, Mandiraja Community Health Center 1 Novita Endang Fitriyani; Iva Rinia Dewi; Dian Novita Octavia
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i5.39231

Abstract

Background: Pharmaceutical services are direct and responsible services to patients with the aim of improving the patient's quality of life. Satisfaction is a feeling of pleasure or disappointment that arises after comparing product performance with expected performance. Satisfaction and service are two things that cannot be separated, with the satisfaction of related parties, they can correct each other how far the improvement in the services that have been provided. Measurement of satisfaction uses five dimensions of service quality, namely tangible evidence (Tangible), responsiveness (responsiveness), assurance (assurance), empathy (Emphaty) and reliability (Reliability). Objective: This study was to describe the level of patient satisfaction with pharmaceutical services in the outpatient pharmacy room at Puskesmas Mandiraja 1. Methods: The type of research was descriptive using a cross sectional approach with the sampling technique of accidental sampling and data collection using questionnaires. Results: Based on the results of calculations on each research indicator the level of patient satisfaction with pharmaceutical services in the outpatient pharmacy room at Mandiraja 1 Health Center is generally categorized as satisfied with the percentage of 75%. The real evidence dimension is 74.15%, the responsiveness dimension is 75.01 %, assurance dimension of 77.44%, the empathy dimension is 75.15% and reliability dimension of 71.07%. Conclusion: Based on the results of the study, the level of patient satisfaction with pharmaceutial services in the outpatient pharmacy room at Puskesmas Mandiraja 1 was in the satisfed category
A 56 Years Old Female with Uncontrolled Diabetes Mellitus Type II, Pneumonia, and Suspect With Lung Abscess: a Case Report Fahreza Fahreza; Diana Novita; Sri Meutia
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i5.38079

Abstract

Background:Diabetes mellitus is a group of metabolic diseases with characteristic hyperglycemia. Proper management of DM patients is essential, and this is useful for controlling appropriate blood glucose levels. If blood glucose levels are uncontrolled, this lead to other complications in other organs, like interference with the immune system. Disruption of the immune system causes the risk of infectious diseases, such as pneumonia and lung abscess.Case Presentation:We report a female patient with a history of type 2 diabetes mellitus, complaining of dyspnea, cough with sputum, high fever, and headache. On chest examination showed left chest movement in the right lung, increased stem fremitus in all right lung fields, dullness in the right upper lung field, and amphoric sound, coarse and wet crackles heard in the right upper lung.  Several supporting examinations, including laboratory and radiological examinations were carried out.Conclusion: The patient was diagnosed with uncontrolled type 2 diabetes mellitus, pneumonia, and a suspected lung abscess. The patient was given several treatments and showed clinical improvement on the fifth day of treatment.
Morbus Hansen Fitria Idris; Wizar Putri Mellaratna
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i5.39371

Abstract

Morbus Hansen (MH) which is called leprosy or leprosy is an infectious disease that causes health problems throughout the world. Leprosy is spread all over the world, especially in tropical and subtropical areas and attacks all ages with the highest frequency in the age group of 20 to 30 years. Case Presentation : Mr. AB, male, aged 33 years, came complaining of numbness and frequent tingling. Hands and feet began to swell and sore. Some toenails fall off unnoticed. Physical examination found composmentis awareness. The general status of the patient was madarosis in both eyelashes, the eyes looked anemic. Ears found infiltrates in both earlobes. Dermatological status in the facial region and superior extremities showed multiple hyperpigmented macules and patches, well defined, geographic shape, sizes vary. Bacteriological examination with Slit Skin Smear on the earlobes found 1-10 Acid-Fast Bacilli (AFB) / 100 fields of view (+1). Bacteriological Index obtained +1. Conclusion: The patient was diagnosed with MB type leprosy accompanied by Erythema Nodusum Leprosum
Correlation between HbA1c Levels with Several Methods of estimated Glomerular Filtration Rate Calculation : Study in type-2 diabetes mellitus patients Septian Eka Prasetyo; Edward Kurnia Setiawan Limijadi; Dwi Lestari Partiningrum; Meita Hendrianingtyas
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i5.38564

Abstract

ABSTRACTBackground: Diabetes Mellitus is a long-term chronic disease characterized by blood glucose levels enhancement (hyperglycemia). Diabetes is closely related to hyperglycemia conditions. Prolonged hyperglycemic conditions can initiate abnormal interactions of metabolic and hemodynamic factors and stimulate the establishment of fibronectin and collagen, including affecting eGFR values. This study analyzed the correlation between HbA1c level and several methods of calculating eGFR in patients with type-2 diabetes mellitus.Objective: Analyzing the correlation between HbA1c levels and several methods of calculating eGFR (CKD-EPI, MDRD, and CG) in patients with type-2 diabetes mellitus.Method: This study was a cross-sectional observational study on 85 research subjects aged over 18 in February to November 2021. The data were taken from medical records of type-2 diabetes mellitus patients at RSND Semarang. The statistical analysis used the Pearson test.Results: The Pearson results showed that there was a significant correlation between HbA1c levels and several methods of calculating eGFR in patients with type-2 diabetes mellitus (p=0,000; r=0,430 in the CKD-EPI method, p=0,000; r=0,384 in the MDRD method, p=0,001; r=0,361 in the CG method).Conclusion: There was a significant positive correlation between HbA1c levels and eGFR CG, MDRD, and CKD-EPI methods in patients with type-2 diabetes mellitus, characterized by increased HbA1c levels and still high eGFR values.Keywords: Diabetes mellitus, HbA1c, eGFR, CKD-EPI, MDRD, CG
Breaking the Chains of Tuberculosis: Quantifying the Effects of Literacy, Population Density, and Access to Improve Sanitation to Support Defense Health and Security in Indonesia Reinpal Falefi; Hikmat Zakky Almubaraq; Nora Lelyana; Makmur Supriyatno
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i5.40353

Abstract

Background: Tuberculosis (TB) is a global health problem. It poses a significant burden worldwide, requiring urgent control measures and research for effective reduction especially in Indonesia.Objective: Investigating the effects of literacy, population density, and access to improved sanitation on TB incidence can provide insights into the relationship between these factors.Methods: This study was conducted in Jakarta, Indonesia from June to July 2023, using secondary data from 2005 to 2021. It employed a quantitative cross-sectional design to examine the relationship between variables. Data were collected from the ASEAN database and analyzed using descriptive and path analysis techniques to determine variable effects and significance. The study found that the incidence of tuberculosis in Indonesia initially decreased from 2005 to 2020 but significantly increased in 2021.Results: Population density, adult literacy rate, and access to improved sanitation all showed positive trends. Significant direct effects were observed among most variables, and indirect effects of population density on tuberculosis incidence were also identified through literacy and sanitation. The final model showed that higher population density correlated with increased access to sanitation and literacy rate, while access to improved sanitation was associated with reduced tuberculosis incidence. Overall, the model had a very good fit based on the indicators.Conclusion: Priority investments in sanitation infrastructure, especially in densely populated areas, along with improved access to sanitation facilities, combined with targeted health education campaigns and collaboration across defense, health, and education sectors, are recommended to enhance tuberculosis prevention and control
Avascular Necrosis Melina Handayani; Muhammad Bayu Rizaldy, Sp.OT
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i5.38551

Abstract

Osteonecrosis can be defined as bone cell death resulting from impaired blood flow to the bone due to traumatic or non-traumatic events. Case Presentation: We present a case in which a 62-year-old female came to the Orthopedic Surgery Polyclinic with complaints of pain in her groin. The pain is intermittent and worsens when the patient moves his legs. This makes it difficult for patients to sit and have pain when walking, so they need a cane as a tool. This complaint has been felt for ± 1.5 years and has been getting worse since this 1 month. During the pain the patient said he was taking pain relievers but his complaints did not decrease. On local examination in the left Hip Joint region, it was found that on look examination there was no visible deformity, swelling and skin color that was the same as the surrounding area. On examination of the feel found positive tenderness. On AP pelvic X-ray examination, there was a fracture of the left femoral head with superior displacement. Treatment for this patient includes non-surgical and surgical (total hip replacement). Conclusion: The patient was diagnosed with Avascular necrosis.
The Effect of Cervical Cancer Counseling on Cervical Cancer Prevention Behavior in Women of Childbearing Age: A Literature Study Miranti Puteri Aulia; Monica Dwi Hartanti
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i5.38759

Abstract

Background: : According to World Health Organization (WHO) data, cervical cancer is the second leading cause of death worldwide . In 2020 the worldwide burden of cervical cancer is significant, there are an estimated 604,000 new infections and 342,000 deaths in 2020. Based on Riskesdas data, the prevalence of tumor/cancer, especially cervical cancer, in Indonesia ranks second with 36,633 cases, accounting for 9.2% of all cancer cases. Effective interventions at various life stages could significantly reduce global mortality from cervical cancer. Objective: This study was conducted to examine the impact of cervical cancer counseling on cervical cancer prevention behavior in women of reproductive age. Methods: Conducting a literature review of previous journal articles related to the effects of cervical cancer counseling on cervical cancer prevention behavior in women of childbearing age. Results: The results of this study indicate that cervical cancer is a significant reproductive health issue in Indonesia due to low screening coverage and lack of knowledge, resulting in late diagnosis. However, education and counseling can play a vital role in increasing awareness and promoting preventive behavior towards cervical cancer. Conclusion: Education and counseling interventions can effectively increase awareness and promote preventive behavior, this promotive and preventive behavior greatly reduces the burden of cervical cancer. 
Study Of Selection Of Delivery Assistance By Tbas In Materials In Masadian Village, Menui Sub-District, Menui Islands, Morowali District Supriyadi Supriyadi; La Ode Liaumin Azim; Rasma Rasma; Mayurni Fardayana Malik; Saasa Saasa
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 5 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i5.38765

Abstract

Backgroud: Nationally, indicators regarding the coverage of delivery services at health facilities have succeeded in achieving the objectives of the 2017 strategic plan, but in several provinces in Indonesia there are still significant differences regarding the coverage of delivery services, for example, Jakarta has the highest coverage at 102%, then Bali at 97.73 %. Meanwhile, Central Sulawesi Province only had an achievement of 76.18%. Objective: This study aims to find out the description of the selection of birth attendants by dukuns for mothers giving birth in Masadian Village, Menui District, Archipelago District, Morowali Regency. Method: This research has a type of quantitative design with a descriptive approach. The population in this study were all birth mothers assisted by traditional birth attendants in 2022, totaling 40 people. the sample in this study was a portion of mothers who were assisted by traditional birth attendants in 2020 as many as 29 respondents. The sampling technique in this study was purposive sampling. The research data was processed using descriptive statistical tests. Result: The results showed that 69% of the respondents had low education and 31% had higher education, 62.1% less knowledge of respondents and 37.9% good category, most of the respondents' economic status was 72.4% low economic and 27 high economic .6%, access to health services 100% access is not affordable, and husband/family support 51.7% do not receive family support and 48.3% receive family support. It is suggested to the puskesmas to provide education to the community which aims to increase the knowledge of mothers, husbands and other families so that they are ready and willing to give birth in midwivesKeywords: birth attendant, traditional birth attendant, knowledge, access, family support 

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