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Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN
Published by Universitas Tanjungpura
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 38 Documents
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Search results for , issue "Vol 1, No 1 (2014): Naskah Publikasi Mahasiswa Farmasi Untan" : 38 Documents clear
UJI AKTIVITAS JAMU GENDONG BERAS KENCUR (Oryza sativa L.; Kaempferia galanga L.) SEBAGAI ANTIDIABETES PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI STREPTOZOTOCIN ., Nur Jannatul Latifah
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 1, No 1 (2014): Naskah Publikasi Mahasiswa Farmasi Untan
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Abstrak : Jamu gendong beras kencur (Oryza sativa  L.; Kaempferia galanga L.)merupakan salah satu bentuk pengobatan tradisional yang memiliki kandungan senyawa fenolik sebagai antioksidan yang berkontribusi terhadap diabetesmellitus. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jamugendong beras kencur terhadap kadar glukosa darah, berat badan, serta gambaranhistologi pulau Langerhans pankreas pada tikus yang diinduksi streptozotocindosis 7 mg/200gBB. Dua puluh lima ekor tikus jantan galur Wistar dibagi dalamlima kelompok, yaitu kelompok normal, kelompok hiperglikemia(Streptozotocin), kelompok hiperglikemia yang diberikan suspensi glibenklamid0,27 mg/200gBB, serta kelompok hiperglikemia yang diberi jamu gendong beraskencur dosis 1,9 mL/200gBB dan 3,8 mL/200gBB. Perlakuan dilakukan selama28 hari dengan pengukuran kadar glukosa darah dan berat badan pada hari ke-0, 4,8, 12, 16, 20, 24, dan ke-28 sedangkan pemantauan gambaran histologi pankreasdilakukan pada hari ke-29. Kadar glukosa darah dan berat badan dianalisis secarastatistik melalui uji One Way Anova dan Post Hoc Tukey HSD, sedangkanpersentase kerusakan Pulau Langerhans dianalisis dengan uji Kruskal Wallis danMann-Whitney. Hasil uji menunjukkan terdapat perbedaan penurunan pada kadarglukosa darah, kenaikan berat badan serta tingkat kerusakan pulau langerhansyang signifikan (p<0.05) antara kelompok perlakuan jamu gendong beras kencurterhadap kelompok Streptozotocin. Hasil penelitian menunjukkan bahwa jamugendong beras kencur memiliki aktivitas antidiabetes yang ditunjukkan denganadanya penurunan kadar glukosa darah, pengontrolan berat badan, serta adanyaperbaikan pulau Langerhans pankreas tikus yang diinduksi streptozotocin dengandosis efektif sebesar 1,9 mL/200gBB. Kata kunci : Diabetes, streptozotocin, jamu gendong beras kencur, glukosadarah, berat badan, histologi pankreas
UJI AKTIVITAS JAMU GENDONG KUNYIT ASAM (Curcuma domestica Val.; Tamarindus indica L.) SEBAGAI ANTIDIABETES PADA TIKUS YANG DIINDUKSI STREPTOZOTOCIN ., Rizqa Ayunda
Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Vol 1, No 1 (2014): Naskah Publikasi Mahasiswa Farmasi Untan
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN

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Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. Jamugendong kunyit asam (Curcuma domestica Val.; Tamarindus indica L.) is a traditional medicine that has antioxidant activity which can contribute to diabeticbecause of the phenolic content. This aim of this study is to determine the effect of jamu gendong kunyit asam on lowering blood glucose levels and repairingdamage of the islet cells. 25 male wistar rats (Rattus norvegicus) were divided into five groups. Group I as a normal group without any treatment, group II, III,IV and V were induced with streptozotocin (7 mg/ 200gBB) then treated with  CMC 1%, glibenclamide (0.27 mg / 200gBB), jamu gendong kunyit asam 1.90ml/ 200gBB and 3.80 ml/ 200gBB. The treatment was done for 28 days.Glucometer was used to measure the gloucose blood level on day 4, 8, 12, 16, 20,24 and 28. The damages on the islet cells were examined under the microscope onthe histology sample of pancreas prepared with Hematoxyllin eosin stain. Dataswere analyzed statistically with One Way Anova test, T-Test, and the KruskalWallistest using SPSS 17.0 for Windows. Results showed there is a significantdifference (p&gt; 0.05) in blood glucose levels and damage to the islets ofLangerhans of the pancreas between the glibenclamide group and treatment ofjamu gendong kunyit asam. From the research it can be concluded that the jamugendong kunyit asam have antidiabetic activity which is  showed by a decrease inblood glucose levels and an improvement of pancreatic islets of Langerhans instreptozotocin-induced diabetic rats with an effective dose of 1.90 ml / 200gBB. Keywords: Diabetes, streptozotocin, jamu gendong kunyit asam, blood glucose, pancreatic histology
ORMULASI TABLET KUNYAH DARI EKSTRAK ETANOL CABAI RAWIT (Capsicum frutescens L.) DENGAN VARIASI PENGISI MANITOL – DEKSTROSA MENGGUNAKAN METODE GRANULASI BASAH ., Kukuh Permadi
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 1, No 1 (2014): Naskah Publikasi Mahasiswa Farmasi Untan
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Cabai rawit (Capsicum frutescens L.)  is a plant that contain flavonoid and had anantioxidant activity. Cabai rawit extracts were made as a chewable tablet with purpose toincrease the acceptablet of herb medicine in the society. This research was done to learn theeffect of variation of filler combination mannitol-dextrose. The chewable tablets were made intothree formulas, FI with combination of mannitol-dextrose (80:20%); FII (50:50%); and FIII(20:80%). The chewable tablet then got physical evaluation such as physical appearance, sizeuniformity, weight uniformity,  hardness, friability, disintegration time and taste response test.The results of the evaluation was the variation of filler combination affect the hardness of tablet,friability, desintegration and the taste of tablet. The best result of physical evaluation ofchewable was FII with combination of mannitol-dextrose (50:50%). Keywords : Cabai rawit, mannitol, dextrose, chewable tablet, wet granulation
FORMULASI SEDIAAN TABLET KUNYAH DARI EKSTRAK ETANOL CABAI RAWIT (Capsicum frutescens L.) DENGAN VARIASI PENGISI MANITOL SUKROSA MENGGUNAKAN METODE GRANULASI BASAH ., Friska Iga Setiadefi
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 1, No 1 (2014): Naskah Publikasi Mahasiswa Farmasi Untan
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Cabai rawit (Capsicum frutescens L.) is one of medicinal plants that containsantioxidant activity. Cabai rawit were made into chewable tablet to improve thetaste from pungency with the sweetener, and also to simplified the administrationof active contents from cabai rawit. The purpose of this research was to formulate atablet from fruit extract of cabai rawit and used combination of filler that couldaffect the physical characteristics of chewable tablet. Chewable tablets were madeinto three formulas used combination of mannitol-sucrose with certain ratio, FI(80:20%), FII (50:50%), and FIII (20:80%). Extracts were made with maserationmethod and the manufacture of chewable tablet used wet granulation method.Granules from the wet granulation were evaluated with several evaluation such asflow properties, and particles size distribution. Granules that had qualified thenwere compressed as chewable tablet and also got psychical characteristicsevaluation such as physical appearance, size uniformity, weight uniformity,hardness test, friability, disintegration time and taste response test. All of theformulas were qualified compared to tablet standard in literature. The best result ofphysical evaluation was FII with angle of repose 26,04°; 5,38 kg of hardness test,0,9% of friability test and 7,27 minutes of desintegration time.  Keywords : chewable tablet, cabai rawit (Capsicum frutescens L.), mannitol,  sucrose, wet granulation
PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN BAWANG MEKAH (Eleutherine americana Merr.) TERHADAP KADAR MALONDIALDEHYDE (MDA) TIKUS (Rattus norvegicus) WISTAR JANTAN PASCA PAPARAN ASAP ROKOK ., Melda Mery Andriyani
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 1, No 1 (2014): Naskah Publikasi Mahasiswa Farmasi Untan
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Abstract: Malondialdehyde (MDA) is a biomarker of lipid peroxidation that is closelycorrelated with level of oxidative stress. The aim of this study was to know ethanolextract activities from E.americana leaves against blood plasma MDA in male Wistar ratsexposed by cigarette smoke using tiobarbituric acid test. The simplicia extracted bymaseration using 70% ethanol. Twenty four rats were divided into six groups, i.e. : anormal group, an exposed cigarette smoke (negative) control group, a positive controlgroup and three treatment groups. One normal group received carboxyl methyl celluloseand another groups exposed cigarette smoke during 14 days. Positive control groupreceived vitamin E (18mg/kg BW), and another groups received ethanol extract ofE.americana leaves doses 180; 90; 45mg/kg BW, respectively. The MDA level wasanalysed by spectrophotometer UV-Visible in 532,2 nm. The MDA level staticallyanalysis by Kruskal-Wallis test and following by Mann-Whitney test. The mean MDAlevels of normal group, negative control group, positive control group and groupsreceived ethanol extract of E.americana leaves doses 180; 90; 45mg/kg BW were0,11±0,09; 13,74±2,84; 0,06±0,03; 10,88±2,19; 0,13±0,03; 0,03±0,02 ppm. The meanMDA levels of groups received ethanol extract of E.americana leaves doses at 180; 1 90mg/kg BW significantly (p<0,05) lower than negative control group. These resultsshow the beneficial effect of ethanol extract of E.americana leaves in the MDA levelreducing on the rats that exposed by cigarette. Key words: Eleutherine americana, cigarette smoke, MDA
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN BAWANG MEKAH (Eleutherine americana Merr.)TERHADAP GAMBARAN HISTOPATOLOGI PARU-PARU TIKUS (Rattus norvegicus) WISTAR JANTAN PASCA PAPARAN ASAP ROKOK ., Hafidzah Ramadhaniyah Al Idrus
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 1, No 1 (2014): Naskah Publikasi Mahasiswa Farmasi Untan
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Exposure to cigarette smoke is one of the exogenous free radicals. Exposure tocigarette smoke is associated with lung inflammation, oxidative stress and lipidperoxidation. Compounds that can inhibit the oxidation reaction by binding free radicalsknown as antioxidants. Eleutherine americana Merr. leaves has an antioxidant activity ininvitro study. The aim of this work was to study E.americana leaves as a naturalantioxidant that reduce the level of lung damage from exposure to cigarette smoke inmale wistar rats and study effective dose of E.americana leaves to reduce the level oflung damage.  The leaves of E.americana extracted by maceration method for 6 daysusing ethanol 70%. Rats were divided into six groups of four animals each : exposed toambient air (GroupA), exposed to cigarette smoke (Group B), exposed to cigarette smokeand treated with ethanol extract of E.americana leaves at dose 45mg/kg bw, 90mg/kg bw,180mg/kg bw (Group C,D,E), exposed to cigarette smoke and treated with vitamin E dose 18mg/kg bb(Group F). All rats were treated for 14 days using 3 cigarettes non filteredeach day by using a smoking chamber. After 14 days rats were killed. Right lungs wereremoved for histopathology. The results showed that dose 45mg/kg bw, 90mg/kg bw,180mg/kg bw can reduce the level of lung damage to the enlarge of alveolar, thickeningof the alveolar wall and inflammatory cell infiltration. Dose 180mg/kg bw as an effectivedose to reduce the level of lung damage that compare to normal control. Keywords : Antioxidant, Eleutherine americana, Lung histopathology, Cigarettesmoke
UJI AKTIVITAS JAMU GENDONG KUNCI SURUH (Boesenbergia pandurata(Roxb.) Schlecht; Piper betle L.) SEBAGAI ANTIDIABETES PADA TIKUS YANG DIINDUKSI STREPTOZOTOCIN ., Rizka Ariyanti
Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Vol 1, No 1 (2014): Naskah Publikasi Mahasiswa Farmasi Untan
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN

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Abstract

Abstrak. Jamu gendong kunci suruh merupakan campuran bahan segar daririmpang temu kunci (Boesenbergia pandurata (Roxb.) Schlecht) dan daun sirih (Piper betle L.) yang memiliki kandungan senyawa yang dapat berperan sebagaiantidiabetes. Penelitian ini bertujuan untuk mengetahui aktivitas jamu gendong kunci suruh sebagai antidiabetes. Dua puluh lima ekor tikus (Rattus norvegicus)Wistar jantan dibagi dalam lima kelompok. Kelompok normal (tidak diinduksiSTZ dan diberikan CMC1% satu kali sehari), kelompok STZ (diinduksi STZ dandiberikan CMC1% satu kali sehari), kelompok glibenklamid (diinduksi STZ dandiberikan glibenklamid 0,27mg/200gBB satu kali sehari), dan kelompok jamugendong kunci suruh dosis 1 dan dosis 2 (diinduksi STZ dan diberikan jamugendong kunci suruh dosis 1 (1,9ml/200gBB) dan dosis 2 (3,8ml/200gBB) duakali sehari). STZ sebagai agen diabetogenik diinduksikan pada tikus dengan dosistunggal 7mg/200gBB secara intraperitonial. Tikus kemudian diberi perlakuanselama 28 hari. Pengukuran kadar glukosa darah dilakukan pada hari ke-0, 4, 8,12, 16, 18, 20, 24, dan 28 menggunakan glukometer. Setelah 28 hari dilakukanhistopatologi pankreas dengan pewarnaan Hematoksilin-Eosin (HE) dan diamati kerusakan pulau Langerhans pankreas dengan mikroskop cahaya. Persentasekerusakan pulau Langerhans pankreas (vakuolisasi dan kongesti) dihitung menggunakan aplikasi ImageJ. Data kadar glukosa darah dianalisis menggunakanmetode One Way ANOVA. Data kuantitatif kerusakan pulau Langerhans pankreasdianalisis menggunakan uji Kruskal Wallis. Hasil penelitian menunjukkan bahwajamu gendong kunci suruh memiliki aktivitas antidiabetes dengan menurunkankadar glukosa darah dan mengurangi kerusakan pulau Langerhans pankreasdengan dosis efektif 1,9ml/200gBB.Kata kunci : streptozotocin, diabetes melitus, jamu gendong kunci suruh
UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN KRIM TIPE M/A DARI MINYAK ATSIRI KULIT BUAH JERUK PONTIANAK (Citrus nobilis Lour. var. microcarpa) TERHADAP ISOLAT Propionibacterium acnes SECARA IN VITRO ., Neny Lucyani
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 1, No 1 (2014): Naskah Publikasi Mahasiswa Farmasi Untan
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Acne is a skin disorder which is caused by the Propionibacterium acnes bacteria. One of thesubstances that can be benefitted as an antibacterial product is Pontianak citrus (Citrus nobilisLour. Var. Microcarpa) peel essential oil. Essential oil is obtained through the process ofsteam distillation. This study aims to determine the effect of formulated antibacterial creamof essential oil of Pontianak citrus’ peel to P. acnes isolates by disc diffusion method (KirbyBauertest).EssentialoilsformulatedindosageformscreamwithessentialoilconcentrationratioF1 (0.025%), F2 (0.05%) and F3 (0,1%). Evaluation of organoleptic examinations ofsuch preparations include odor, color, shape and homogeneity, dispersive power testing,adhesion, pH and antibacterial. Data analysis is done by using the R-Commander programversion 2.14.1. The results showed that the inhibitory zone in F1, F2 and F3 is 18mm, 20mmand 21,67mm. The evaluation results indicate a homogeneous preparation, pH is inaccordance to the peel’s pH and there is a decrease of adhesion and increase of dispersivepower. The results of antibacterial cream evaluation showed that formula 1 gives the besteffectiveness with inhibition zone of 18 mm to the P. acnes isolates. Keyword: Acne, Pontianak citrus peel essential oil, P. acnes
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN BUASBUAS (Premna cordifolia Linn.) TERHADAP GAMBARAN HISTOPATOLOGI PARU TIKUS (Rattus norvegicus) WISTAR JANTAN PASCA PAPARAN ASAP ROKOK ., Kristina Lusty Tohomi
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 1, No 1 (2014): Naskah Publikasi Mahasiswa Farmasi Untan
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Cigarette smoke is one of free radical source that can cause oxidative stress, emphysema, and inflamation on lung. Leaves of Premna cordifolia Linn. isone of antioxidant that can neutralize the free radical in body. The purpose of theresearch  is to find the antioxidant activity of Premna cordifolia leaves in reducinglung’s damage and to find the effective dose that can reduce lung’s damage afterexposure of cigarette smoke. Dried leaves of Premna cordifolia are maseratedwith ethanol 70%.  Rats are divided into five groups, Group without treatment(CMC control), group that exposed to smoke, three groups that treated with 200(P1), 400 (P2), and 600mg/kgBW (P3) of ethanolic extract of Premna cordifolialeaves after smoke exposure, and one group that treated with 18mg/kgBW ofvitamin E as positive control after smoke exposure. All groups were treated withthree cigarette without filter for 14 days. All rat were terminated on the fifteentday. Right lung were collected and subjected to necropsy and stained withHematoksilin-Eosin. The result show that all doses of ethanolic extract of Premnacordifolia reduce lung damage in enlarge alveolar, thickening of alveolar’s wall,and infiltration of inflmation cells in rats. The effective dose is 600mg/kgbwbecause the potential of Premna cordifolia leaves extract was same with thepotential of positive contol in reducing the lung damage. Keywords : Antioxidant, Premna cordifolia, Lung histopathology, Cigarettesmoke
UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN SABUN MANDI CAIR MINYAK ATSIRI KULIT BUAH JERUK PONTIANAK (Citrus nobilis Lour. Var. microcarpa) TERHADAP Staphylococcus aureus dan Escherichia coli ., Risky Rosdiyawati
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 1, No 1 (2014): Naskah Publikasi Mahasiswa Farmasi Untan
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Infection can caused by the pathogenic bacteria like Staphylococcusaureus and Escherichia coli. Synthetic antibacterial compounds could preventinfection but also had side effect,for example irritation. This became a trigger toproduced another product based on nature. Essential oil from Pontianak orangepeel (Citrus nobilis Lour. var. microcarpa) that contain antibacterial activity couldbe used to formulate the product. The purpose of this research was to know theeffectiveness of antibacterial activity of liquid soap from essential oil of Pontianakorange peel againts Staphylococcus aureus and Escherichia coli using discdiffusion method. This research was conducted with experimental method andused variation of essential oil concentration such as FI (0,05%); F2 (0,15%);F3(0,25%). The liquid soap then got physical and chemistry analysis such asorganoleptic, foaming power, density, viscosity, pH, and total fatty acids and alsoirritation test. The results of the research showed that the three formulas of liquidsoaps fulfill SNI’s standard of liquid soaps, not cause irritation and also showedbest effectiveness at F1 (0,05%) with 7,17 mm zone of inhibition ofStaphylococcus aureus and 18,59 mm zone of inhibition  of Escherichia coli.Keywords: antibacterial, essential oil of Pontianak orange peel, liquid soap

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