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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 24 Documents

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Search results for , issue "Vol 4, No 1 (2014): Pharmaciana" : 24 Documents clear

PERBANDINGAN EFEKTIVITAS MISOPROSTOL DOSIS 50 Âµg DAN 100 Âµg TERHADAP KEBERHASILAN KELAHIRAN INDUKSI DI RSU PKU MUHAMMADIYAH YOGYAKARTA Dania, Haafizah; Wahyono, Djoko; Retnowati, Sulistiari
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

In recent years, misoprostol that is a prostaglandin E1 analogue has been used in cervix ripeningat pregnancy and labor induction. However, until now misoprostol dosage and administration route forinduction are various. There is no fix guide on administration and dosage of misoprostol. This researchwas intended to identify profile of misoprostol usage and effectiveness of misoprostol administrationat dosage of 50 Âµg and 100 Âµg on labor process progress of patient hospitalized in Yogyakarta PKUMuhammadiyah Hospital based on induction success. This research was non experimental research with historical cohort design. Limitation of this method was not all desired data exist in medical recordand capability of physician was not same. Subject was pregnant mothers giving birth with misoprostolinduction process in delivery room in Yogyakarta PKU Muhammadiyah Hospital from 1 January 2009to 31 December 2010. Data was obtained from medical record, which was then analyzed descriptivelyanalytically to identify misoprostol usage profile and effectiveness of misoprostol tablet administrationat 50 Âµg and 100 Âµg dosage on labor process progress. Research subjects who meet the inclusioncriteria in this research was 109 mothers, where 69 women (63,30%) got 50 Âµg misoprostol and 40women (36,70%) got 100 Âµg misoprostol. The results of this study indicate that the success ofinduction at 50 ug misoprostol group decreased by 89% compared with 100 ug misoprostol group (RR= 0.11), where the success of 50 ug misoprostol induction for 56 people from 69 people (81.16%),while the success induction at 100 ug misoprostol group as many as 39 people from 40 people(97.50%). The difference was statistically significant with p = 0.014 (p <0.05).

EFEK FRAKSI ETIL ASETAT EKSTRAK ETANOL AKAR PASAK BUMI (Eurycoma longifolia, Jack) TERHADAP AKTIVITAS FAGOSITOSIS MAKROFAG SECARA IN VITRO Arifah, Aminda Nur; Nurkhasanah, Nurkhasanah
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Eurycoma longifolia has been used as a remedy for detoxification, aphrodisiaca, anticancer andimmunistimulant. The quassinoids of pasak bumi root extract, have antioxidant activity andimmunomodulatory activity by increasing IL-12. This study aims to determine the effect of the ethylacetate fraction of ethanolic extract of pasak bumi root on macrophages phagocytic activity in vitro.Macrophages were isolated from peritoneal fluid of male Balb/Cmice, and thenwere cultured for 24hours in 24 well plate. The ethyl actetate fraction ethanolic extract of pasak bumi root withconcentration of 10, 50, and 100 Âµg/ml, lipopolysaccharides and dimethyl sulfoxide were added, andincubated for 1.5 hours. The phagocytosis tests was carried out by adding latex with density5x104/well and incubated for 1.5 hours at incubator (5% CO2,37oC). Macrophage were then stained byGiemsa. The results showed that the percentage of active phagocytic cells treated with ethyl actetatefraction of ethanolic extract of pasak bumi root of 10, 50 and 100 Âµg/ml, lipopolysaccharides, anddimethyl sulfoxide were 95.4%, 90%, 85.4%, 83.4%, and 79% respectively. Phagocytic capacity attreatment levels of 10, 50, and 100 Âµg/ml, lipopolysaccharides,and dimethyl sulfoxide were 469; 439.8; 360.8; 204.6; and 147.6 respectively. The result showed thatreatment of ethyl acetate fractionof ethanolic extract of pasak bumi root can increase the phagocytic activity of macrophages in vitro.

PENGEMBANGAN FORMULASI MASKER EKSTRAK AIR DAUN ALPUKAT (Persea americana Mill) SEBAGAI ANTIBAKTERI Staphylococcus aureus UNTUK PENGOBATAN JERAWAT Lestari, Tri; Ismiyati, Nur
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Skin problems are often on the spotlight, one of them is acne. Inflammation of acne can betriggered by the bacteria Propionibacterium acne, Staphylococcus epidermidis and Staphylococcusaureus. One of the herbs that can be used for acne treatment is the leaves of avocado (Perseaamericana). This study aims to determine the potential antibacterial activity of avocado leafwater extract on the growth of Staphylococcus aureus bacteria that causes acne and mask-makingformulation preparation. Antibacterial activity test was carried out by the diffusion method and theobserved inhibition zone that occured in a series of concentrations of avocado leaf water extract (15%, 17.5% , 35% , 50% , 75%). Antibacterial activity test was also conducted on some avocado leafwater extract mask formula (17.5% , 35% , 50% , 75%) was evaluated the physical properties of themask and irritation test was done. The results showed that the avocado leaf water extract mask formulahad antibacterial activity greater than the extract form. The physical condition evaluation and irritationtest showed that the best mask formulation was concentration of 35%.

EKSTRAKSI ANDROGRAFOLID DARI Andrographis paniculata (Burm.f.) Nees MENGGUNAKAN EKSTRAKTOR SOXHLET Rais, Ichwan Ridwan
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Chemical component extraction from plant herbal influenced by various aspect, such asextraction technique or chemical component character from the plant. Extraction method and solventpolarity exteremly influence chemical component transfer from the cell of plant to solvent solution.Soxhlet is extraction system instrument with frequently same solvent extraction based on liquid-steamcirculation process of the solvent. Solvent polarity to extract chemical component of the plant herbaldepend on chemical component character it self and ability to penetrate cell membrane.Andrographolide, an active chemical component of Andrographis paniculata has been suggested themost active constituent that responsible to activity of Andrographis paniculata in herbal medication.This chemical constituen has solubility character in solvent with middle polarity that indicates solventelection to extract it. This study shows that chemical component extraction of herbal plant influencedby solvent polarity. Thin Layer Chromatography qualitative analyses indicate that absolute polar andAndrographis paniculatanonpolar solvent could not extract andrographolide, different from middle polarity. Andrographolideextraction with similar solvent and correct method offer extract yield with 16,6% andrographolide.

PENGHAMBATAN AKTIVITAS XANTHINE OXIDASE OLEH EKSTRAK ETANOL SARANG SEMUT (Myrmecodia tuberosa (non Jack) Bl.) SECARA IN VITRO Ernawati, Ernawati; Susanti, Hari
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Uric acid is the end product of purine metabolism that can settle in the joints and form smallcrystals, causing inflammation known as gout. Gout is a disease caused by high levels of uric acid inthe blood (hyperuricemia). One of the drugs used to treat gout was allopurinol to inhibite the activityof xanthine oxidase mechanism. Myrmecodia tuberosa (non Jack) Bl. known to contain flavonoids andempirically proven to treat rheumatic complaints and gout. Therefore, research needs to examinewhether the ethanol extract of the sarang semut to inhibite xanthine oxidase activity. Allopurinol isused as a comparison. The active substances of the Myrmecodia tuberosa (non Jack) Bl. was extractedwith ethanol using maceration method after soaked with petroleum ether. The xanthine oxidaseinhibitor activity of the Myrmecodia tuberosa (non Jack) Bl production ethanol extract wasspectrophotometrically determined by monitoring the reducing of uric acid at a wavelength(Î») 295 nm with xanthine as substrate. Rate values obtained subsequently used to calculate the valueof the activity. Then determined the concentration of the ethanol extract can inhibit the activity ofof xanthine oxidase by 50% (IC50). The results of the research showed that the ethanol extracts of sarang semut inhibited xanthine oxidase activity with IC50 112.40 Âµg/ml, while allopurinol was3.16 Âµg/ml.

UJI TOKSISITAS SUBKRONIS EKSTRAK CURCUMA BEBAS MINYAK ATSIRI (ECBA) DITINJAU DARI PARAMETER PROFIL LEUKOSIT PADA TIKUS PUTIH GALUR WISTAR Farida, Verda; Ikawati, Zullies; Pramono, Suwidjiyo
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The effect of Volatil Oil of Curcuma Extraxt or Curcumin extract withcentration of essential oil in reducing the levels of cholesterol in the blood has beenECBA as antihyperlipidemic agent is given for a long - term therapeutic purpose. Thisexperiment was performed to investigate the subchronic toxicity of ECBA on leukocytes profile ofWistar rats. ECBA was investigated at dose 15 mg, 120 mg, and 960 mg/200 g body weight for 90days in 40 male Wistar rats. CMC-Na was used for control. The blood was examined for theleukocytes profile on day 0, 45, and 90. The rats were still maintained under experimental conditionswithout giving ECBA until day 105 for the reversibility test. The result showed that the administrationof ECBA for 90 days did not affect leukocytes profile of Wistar rats.

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL HERBA PEGAGAN (Centella asiatica (L.) Urb) DENGAN METODE FOSFOMOLIBDAT Salamah, Nina; Farahana, Liani
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antioxidant compound extends widely used to prevent degenerative disease. Centella asiatica(L.) Urb or known as pegagan is a plant which grown in Indonesia and itâs leaves contain somecompounds reported to have antioxidant activities. The research aimed to know antioxidant activity ofethanolic extract of pegagan herbs by mechanism of reducing power. The antioxidant activity analyzedusing visible spectrophotometric with phosphomolybdate method. Antioxidant activity of ethanolicextract of pegagan was expressed as mg quercetin equivalence/gram extract). The result showed thatusing this method the ethanolic extract of pegagan activity had antioxidant activity which is43.198 Â± 2.048 mg mgQE/gram extract.

ANALISIS KEPUASAN MAHASISWA TERHADAP KUALITAS PELAYANAN TENAGA ADMINISTRATIF DI FAKULTAS FARMASI UNIVERSITAS AHMAD DAHLAN YOGYAKARTA Hidayati, Ana; Fudholi, Achmad; Sumarni, Sumarni
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Student satisfaction measurement has been done with populatif observation and data collectedprospectively at the fourth level students of the Faculty of Pharmacy Ahmad Dahlan University. Thepurpose this study to describe and determine student satisfaction ratings gap that arises from servqual.The results obtained indicate generally that the service element in the Faculty of Pharmacy is namelyemployees has not given in accordance with the expectations of student performance is characterizedby a range of values of each gap there is nothing close to the ideal of zero (0). Gap values ofemployees in the education ministry on Tangible dimensions with a gap value -0,90, Reliability withthe gap value -0,90, Assurance gap value -0,90, Empathy with the gap value -1,10 andResponsiveness to the value gap -1,10 . While the reliability of the employee dimension into the first rank and dimensions of responsiveness on the faculty is considered the most excellent service tostudents.

PENGEMBANGAN SENYAWA TURUNAN BENZALASETON SEBAGAI SENYAWA TABIR SURYA Prabawati, Susy Yunita; Wijayanto, A; Wirahadi, Aria
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The goal of this research was to synthesize benzalaceton derivative i.e. 4-dimethyl-aminodibenzalacetonto increase the potency as sunscreen agent. The synthesis was carried out through aldolcondensation reaction with 4- dimetilamino-benzaldehida as a starting material and NaOH as catalystat various reaction times i.e. 3 , 4 and 6 hours. The characterizations of the product was observed bymelting point, FTIR and 1H NMR spectrometers. The product was obtained as a yellowish orangesolid with a melting point between 62-640C. The activity assay as sunscreen agent showed that the 4 âdimethylamino-dibenzalaseton have a maximum wavelength at 340 nm, so its can be active as asunscreen in the UV - A rays. The SPF value at 15 ppm was 17.409 with ultra protection type.

EFEK HIPOGLIKEMIK EKSTRAK ETANOL UMBI KETELA RAMBAT (Ipomoea batatas P) (EEUKR) PADA MENCIT SWISS YANG DIINDUKSI ALOKSAN Akrom, Akrom; D, Harjanti P; T, Armansyah
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Sweet potatos rood contain lots of beta-carotene, polyphenols and flavonoids. Alloxan provenpancreatic cell damage through oxidative stress mechanisms. The compound beta-carotene,polyphenols and flavonoids are thought to antioxidative and cytoprotective, inhibit cell damage causedby alloxan exposure. This study aimed to determine the effect of ethanolic extract of sweet potatos(Ipomoea batatas P) (EEUKR) on blood glucose levels and pancreatic histopathology on alloxaninducedSwiss mice. Used 15 test animals, Swiss mice, with an average weight of 20-30 grams. Testanimals were divided into 5 groups, with each group consisting of 3 mice. Group I was the negativecontrol group who were given distilled water (akua group), and group II, III, IV and V are thetreatment group were given ethanolic extract of sweet potatos rood (EEUKR) at a dose of 2.5, 7.5,22.5 and 67.5 mg/KgBW/day orally for 10 days, 7 days before and 3 days after the alloxan induced.Alloxan induction performed on the 7th day intraperitoneally at a dose of 120 mg/kgBW. Examinationof blood glucose levels conducted on 4th and day 10th day of treatment. On the 10th day of the testanimals were sacrificed for isolated pancreas and histopathologic examination. Analysis of varianceconducted to determine the significance difference in average blood glucose levels between groupsduring the test and ANOVA followed by LSD test at 95% confidence level. Pancreatic histopathologydata were analyzed qualitatively. The results showed that the EEUKR dose of 22.5 and 67.5mg/kgBW/day had the effect of hypoglycemia in Swiss mice. Blood glucose levels of Swiss micebefore alloxan induced in treatment group with EEUKR dose of 67,5 mg/Kg BW were lower thanblood glucose levels of akua groups, statistically significant (p <0,05). Blood glucose levels of alloxaninduced swiss mice of treatment groups with EEUKR dose of 22.5 and 67.5 mg/KgBW were lowerthan blood glucose level of akua group and statistically significant (p <0.05). The percentage ofpancreatic necrosis of alloxan-induced Swiss mice of treatment groups with EEUKR dose of 22.5 and67.5 mg/kg BW were lower than the percentage of necrosis of akua group. Based on these results itcan be concluded that the EEUKR doses of 22.5 and 67.5 mg/KgBW are found to be hypoglycemic inSwiss mice both before and after alloxan induced. The EEUR also shown to decrease the incidence ofpancreatic necrosis in alloxan-induced Swiss mice.

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA